Study of the toxicological characteristics of water-soluble surface-active substances obtained based on phenol, formaldehyde and sodium sulphite

Authors

  • Nadiia Sokolenko Institute of Chemical Technologies of the Volodymyr Dahl East Ukrainian National University, 31, Vladimirska str., Rubizhne, Lugansk region, Ukraine, 93009, Ukraine https://orcid.org/0000-0002-1319-2625
  • Elina Ruban Institute of Chemical Technologies of the Volodymyr Dahl East Ukrainian National University, 31, Vladimirska str., Rubizhne, Lugansk region, Ukraine, 93009, Ukraine https://orcid.org/0000-0002-0641-3709
  • Victor Ostrovka Institute of Chemical Technologies of the Volodymyr Dahl East Ukrainian National University, 31, Vladimirska str., Rubizhne, Lugansk region, Ukraine, 93009, Ukraine https://orcid.org/0000-0001-6946-7475
  • Moroz Oleksiy Institute of Chemical Technologies of the Volodymyr Dahl East Ukrainian National University, 31, Vladimirska str., Rubizhne, Lugansk region, Ukraine, 93009, Ukraine https://orcid.org/0000-0003-1700-9039
  • Yevgeniy Popov Institute of Chemical Technologies of the Volodymyr Dahl East Ukrainian National University, 31, Vladimirska str., Rubizhne, Lugansk region, Ukraine, 93009, Ukraine https://orcid.org/0000-0001-7941-5134
  • Anna Sedych Luhansk State Medical University, 32, Budivelnykiv str., Rubizhne, Lugansk region, Ukraine, 93012, Ukraine https://orcid.org/0000-0003-4034-7095

DOI:

https://doi.org/10.15587/2312-8372.2020.193074

Keywords:

condensation product of phenol, formaldehyde and sodium sulphite, surfactants, toxicology, lethal dose

Abstract

The object of research is the products of the condensation reaction of phenol, formaldehyde and sodium sulfite in an aqueous medium, in order to obtain water-soluble non-toxic products based on it, which can be proposed for use as surfactants. In the course of the study, the effect of the reaction conditions (ratio of components, temperature and process time) on the quality of the products obtained and their toxicological characteristics are studied. The optimal ratio of the starting reagents phenol: formaldehyde: sodium sulfite: water is selected, which allows to obtain a product with surface-active properties and which contains substances that can be harmful to health. It is recommended that the condensation process be carried out within 1 hour, the optimum reaction temperature is selected at 130 °C. The qualitative characteristics of the obtained product allow to recommend its use as an anionic surfactant. For this, the symptomatic and toxicological properties of the newly developed surfactant, the product of the condensation of phenol, formaldehyde and sodium sulfite in an aqueous medium, are studied. Based on the studies, it is found that with the introduction of such surfactants into the stomach of experimental white rats-females, their slightly irritating effect on the mucous membranes and skin is observed. According to the mortality criterion, with a single oral administration (LD50), the harmful effects of the substance on rats are not noted. According to the research results, the product can be attributed to class IV hazard (low hazard substances) according to GOST 12.1.007.

According to toxicological findings, the resulting product can be recommended for use as a textile auxiliary substance, in the technological operations of bleaching, dyeing and printing of fabrics in contact with human skin, as well as additives to concrete mixtures used in the construction industry and other industries

Author Biographies

Nadiia Sokolenko, Institute of Chemical Technologies of the Volodymyr Dahl East Ukrainian National University, 31, Vladimirska str., Rubizhne, Lugansk region, Ukraine, 93009

Department of Ecology and Polymer Technology

Elina Ruban, Institute of Chemical Technologies of the Volodymyr Dahl East Ukrainian National University, 31, Vladimirska str., Rubizhne, Lugansk region, Ukraine, 93009

PhD, Associate Professor

Department of Ecology and Polymer Technology

Victor Ostrovka, Institute of Chemical Technologies of the Volodymyr Dahl East Ukrainian National University, 31, Vladimirska str., Rubizhne, Lugansk region, Ukraine, 93009

Senior Lecturer

Department of Ecology and Polymer Technology

Moroz Oleksiy, Institute of Chemical Technologies of the Volodymyr Dahl East Ukrainian National University, 31, Vladimirska str., Rubizhne, Lugansk region, Ukraine, 93009

Senior Lecturer

Department of Ecology and Polymer Technology

Yevgeniy Popov, Institute of Chemical Technologies of the Volodymyr Dahl East Ukrainian National University, 31, Vladimirska str., Rubizhne, Lugansk region, Ukraine, 93009

Doctor of Technical Sciences, Professor

Department of Ecology and Polymer Technology

Anna Sedych, Luhansk State Medical University, 32, Budivelnykiv str., Rubizhne, Lugansk region, Ukraine, 93012

PhD, Associate Professor, Head of Department

Department of Medical Chemistry

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Published

2019-12-24

How to Cite

Sokolenko, N., Ruban, E., Ostrovka, V., Oleksiy, M., Popov, Y., & Sedych, A. (2019). Study of the toxicological characteristics of water-soluble surface-active substances obtained based on phenol, formaldehyde and sodium sulphite. Technology Audit and Production Reserves, 1(3(51), 44–47. https://doi.org/10.15587/2312-8372.2020.193074

Issue

Vol. 1 No. 3(51) (2020): Chemical engineering

Section

Reports on research projects

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Copyright (c) 2020 Nadiia Sokolenko, Elina Ruban, Victor Ostrovka, Moroz Oleksiy, Yevgeniy Popov, Anna Sedyh

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