Thyroid function in full-term small-for-gestational-age (SGA) children during rGH-therapy




small-for-gestational age, thyroid, thyrotropic hormone, thyroxin, growth hormone


There was not established any influence of the treatment with the recombinant growth hormone (rGH) on the thyroid function in full-term small-for-gestational age SGA) children.  The aim of the research was the study of the level of serum thyroxin of free (Т4) and thyrotropic hormone (TTH) in SGA children before and after rGH treatment; determination of possible influence of a body mass and length at birth, thyroid hormones on the further spontaneous growth.

Methods. The research included 58 full-term SGA children (25 with spontaneous growth, 33 undersized), pre-pubertal. The measuring of levels of free T4 and TTG was realized before and in 6 and 12 months after rGH treatment.   

Results. Indices of free T4 and TTG don’t correlate with a standard deviation score (SDS) of a body mass and length at birth, body mass index and IGF-1. The average level of free T4 was decreasing during the first 6 months of rGH treatment, but remained within norm. TTG didn’t change during the treatment. The change of free T4 doesn’t correlate with the change of SDS of the growth speed during 12 months after rGH treatment.

Conclusion. TG level doesn’t correlate with SDS of a body mass and body length at birth. The level of free Т4 decreases at rGH treatment, but it is not connected with TTG increase and doesn’t influence rGH treatment effectiveness. As far as such inessential changes in the thyroid function are not clinically important, frequent observation on the thyroid function at rGH treatment is not substantiated in full-term SGA children. Monitoring in such children must be realized once a year with determining TTG and free Т4 levels in blood plasma

Author Biographies

Nataliia Muz, SI “V. P. Komisarenko Institute of Endocrinology and Metabolism of NAMS of Ukraine” Vyshhorodska str., 69, Kyiv, Ukraine, 04114


Department of Pediatric Endocrine Pathology

Olena Bolshova, SI “V. P. Komisarenko Institute of Endocrinology and Metabolism of NAMS of Ukraine” Vyshhorodska str., 69, Kyiv, Ukraine, 04114

MD, Professor, Head of Department

Department of Pediatric Endocrine Pathology


  1. Ortiga-Carvalho, T. M., Chiamolera, M. I., Pazos-Moura, C. C., Wondisford, F. E. (2016). Hypothalamus-Pituitary-Thyroid Axis. Comprehensive Physiology, 13 (6), 1387–1428. doi: 10.1002/cphy.c150027
  2. Hulbert, A. J. (2000). Thyroid hormones and their effects: a new perspective. Biological Reviews of the Cambridge Philosophical Society, 75 (4), 519–631.
  3. Bloise, F. F., Cordeiro, A., Ortiga-Carvalho, T. (2017). Role of thyroid hormone in skeletal muscle physiology. Journal of Endocrinology, 235 (3), 223–235. doi: 10.1530/joe-16-0611
  4. Forhead, A. J., Fowden, A. L. (2014). Thyroid hormones in fetal growth and prepartum maturation. Journal of Endocrinology, 221 (3), 87–103. doi: 10.1530/joe-14-0025
  5. De Kort, S. W. K., Willemsen, R. H., van der Kaay, D. C. M., van Dijk, M., Visser, T. J., Hokken-Koelega, A. C. S. (2008). Thyroid function in short children born small-for-gestational age (SGA) before and during GH treatment. Clinical Endocrinology, 69 (2), 318–322. doi: 10.1111/j.1365-2265.2008.03195.x
  6. Karlberg, J., Albertsson-Wikland, K. (1995). Growth in Full- Term Small-for-Gestational-Age Infants: From Birth to Final Height. Pediatric Research, 38 (5), 733–739. doi: 10.1203/00006450-199511000-00017
  7. Radetti, G., Fanolla, A., Pappalardo, L., Gottardi, E. (2007). Prematurity May Be a Risk Factor for Thyroid Dysfunction in Childhood. The Journal of Clinical Endocrinology & Metabolism, 92 (1), 155–159. doi: 10.1210/jc.2006-1219
  8. Albertsson-Wikland, K., Boguszewski, M., Karlberg, J. (1998). Children Born Small-for-Gestational Age: Postnatal Growth and Hormonal Status. Hormone Research, 49, 7–13. doi: 10.1159/000053080
  9. Seminara, S., Stagi, S., Candura, L., Scrivano, M., Lenzi, L., Nanni, L. et. al. (2005). Changes of Thyroid Function During Long-term hGH Therapy in GHD Children. A Possible Relationship with Catch-up Growth? Hormone and Metabolic Research, 37 (12), 751–756. doi: 10.1055/s-2005-921104
  10. Guemes Hidalgo, M., Fernandez de Larrea Baz, N., Munoz Calvo, M. et. al. (2013). Response to 3 years of growth hormone therapy in small for gestational age children: clinical, hormonal and metabolic parameters. Anales de Pediatria, 78 (5), 288–296. doi: 10.1016/j.anpedi.2012.08.010
  11. Keskin, M., Bayramoglu, E., Aycan, Z. (2017). Effects of 1-year growth hormone replacement therapy on thyroid volume and function of the children and adolescents with idiopathic growth hormone deficiency. Journal of Pediatric Endocrinology and Metabolism, 30 (11), 1187–1190. doi: 10.1515/jpem-2017-0210
  12. Labarta, J., Ruiz, J., Molina, I., De Arriba, A., Mayayo, E., Longas, A. F. (2009). Growth and growth hormone treatment in short stature children born small for gestational age. Pediatric Endocrinology Reviews, 6 (3), 350–357.
  13. Krishnamurthy, M. B., Popiel, A., Malhotra, A. (2017). Screening investigations in small-for-gestational-age near-term and term infants. European Journal of Pediatrics, 176 (12), 1707–1712. doi: 10.1007/s00431-017-3031-8
  14. Van der Steen, M., Hokken-Koelega, A. C. S. (2016). Growth and Metabolism in Children Born Small for Gestational Age. Endocrinology and Metabolism Clinics of North America, 45 (2), 283–294. doi: 10.1016/j.ecl.2016.01.008
  15. Smeets, C. C. J., van der Steen, M., Renes, J. S., Hokken-Koelega, A. C. S. (2017). Bone Mineral Density After Cessation of GH Treatment in Young Adults Born SGA: A 5-Year Longitudinal Study. The Journal of Clinical Endocrinology & Metabolism, 102 (9), 3508–3516. doi: 10.1210/jc.2017-00269
  16. Franco, B., Laura, F., Sara, N., Salvatore, G. (2013). Thyroid function in small for gestational age newborns: a review. Journal of Clinical Research in Pediatric Endocrinology, 5 (1), 2–7. doi: 10.4274/jcrpe.846
  17. Cianfarani, S., Ladaki, C., Geremia, C. (2006). Hormonal Regulation of Postnatal Growth in Children Born Small for Gestational Age. Hormone Research in Paediatrics, 65 (3), 70–74. doi: 10.1159/000091509
  18. De Zegher, F. (2004). Endocrinology of Small-for-Gestational-Age Children: Recent Advances. Hormone Research in Paediatrics, 62 (3), 141–142. doi: 10.1159/000080516
  19. Bolshova, E. V., Sprynchuk, N. A., Muz, N. N. et. al. (2015). Clinical features and hormonal status of children born small for gestational age. Pediatriia. Vostochnaya Europa, 1 (9), 79–87.
  20. Agha, A., Walker, D., Perry, L., Drake, W. M., Chew, S. L., Jenkins, P. J. et. al. (2007). Unmasking of central hypothyroidism following growth hormone replacement in adult hypopituitary patients. Clinical Endocrinology, 66, 72–77. doi: 10.1111/j.1365-2265.2006.02688.x



How to Cite

Muz, N., & Bolshova, O. (2017). Thyroid function in full-term small-for-gestational-age (SGA) children during rGH-therapy. ScienceRise: Medical Science, (11 (19), 48–51.



Medical Science