Motor and non-motor manifestations of benign multiple sclerosis: the results of a 5-year prospective study
DOI:
https://doi.org/10.15587/2519-4798.2019.161729Keywords:
multiple sclerosis, benign multiple sclerosis, failure, prospective study, functional scalesAbstract
The aim of our work was to assess the motor and non-motor effects of the disease in patients with benign multiple sclerosis (MS) during the 5-year follow-up period.
Materials and methods: the observational, prospective five-year, double-blind study of patients with benign MS was conducted for the first time in Ukraine. On the basis of the electronic register of patients with multiple sclerosis in the Volyn region, a group of patients with benign multiple sclerosis according to the following criteria: duration of MS for more than 10 years, full or partial working capacity, degree of disability of EDSS ≤4 points was allocated in 2012-2013. In 2017–2018 a reassessment of patients with benign MS was performed. According to the degree of disability on the EDSS scale, at the stage of inclusion in the study, patients were divided into three groups: the first group includes patients with a degree of EDSS ≤2.0 points, to the second group - with an EDSS degree of 2.5–3.5 points, to the third group - with the degree of EDSS ≤4.0 points.
Results: there were included 74 persons, age 46.44±8.36 years into analyses. According to the degree of EDSS step at the stage of inclusion in the study, patients were divided into three groups. The demographic, clinical and paraclinical characteristics were evaluated. It has been established that the initial level of functional disability on the EDSS scale is not a determining factor in the assessment of the level of disability and employment after 5 years. Progression of the disease was observed regardless of the initial level of EDSS in at least two functional scales.
Conclusions: the proportion of benign multiple sclerosis after 15 years of follow-up was 9.76 %. With a lower initial score on the EDSS scale, there is an increase in motor manifestations, with more – non-motor syptoms of multiple sclerosis. Progression of the disease is observed in at least two functional scales
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