Influence of recombinant growth hormone treatment on the state of pituitary-thyroid and pituitary-adrenal systems in children with syndrome of biologically inactive growth hormone

Authors

  • Nataliia Sprynchuk State Institution “V. P. Komisarenko Institute of Endocrinology and Metabolism of National Academy of Medical Sciences of Ukraine” Vyshhorodska str., 69, Kyiv, Ukraine, 04114 P. L. Shupyk National Medical Academy of Postgraduate Education Dorohozhytska str., 9, Kyiv, Ukraine, 04112, Ukraine https://orcid.org/0000-0002-6729-6323
  • Olena Bolshova State Institution “V. P. Komisarenko Institute of Endocrinology and Metabolism of National Academy of Medical Sciences of Ukraine” Vyshhorodska str., 69, Kyiv, Ukraine, 04114, Ukraine https://orcid.org/0000-0003-1999-6031

DOI:

https://doi.org/10.15587/2519-4798.2019.161763

Keywords:

biologically inactive growth hormone, pituitary gland, thyroid gland, adrenal glands, treatment

Abstract

Combined insufficiency of adenohypophysis such as thyrotropic and adrenocorticotropic, especially during treatment with recombinant growth hormone, were often observed among children with somatotropic insufficiency.

Aim. To evaluate the adaptation mechanisms of the organism based on studying the peculiarities of pituitary-thyroid and pituitary-adrenal functions in patients with syndrome of biologically inactive growth hormone on the background of recombinant growth hormone treatment.

Materials and methods. There were examined 158 patients with syndrome of biologically inactive GH (49 girls and 109 boys); the mean age of patients was 8.3 ± 0.24 years. The levels of thyrotropic hormone, thyroxine, triiodothyronine, thyroid peroxidase antibody, adrenocorticotropic hormone, and cortisol were determined. The examinations were performed before and against the recombinant growth hormone treatment for 6 months. The control group consisted of 42 healthy children (12 girls and 30 boys), the age was from 5 to 16 years.

Results. The levels of thyrotropic hormone in blood plasma of children with syndrome of biologically inactive growth hormone were increased but remained within the normal range during therapy with recombinant growth hormone. Peripheral indices of thyroid function in patients with syndrome of biologically inactive growth hormone, according to free thyroxine, before treatment and against the background of the recombinant growth hormone use almost had no differences and did not reach a significant difference, although they tended to decrease compared with the control group. The levels of adrenocorticotropic hormone and cortisol in blood plasma of children with syndrome of biologically inactive growth hormone before recombinant growth hormone treatment comparing to the control group did not have significant differences. Recombinant growth hormone therapy for 6 months resulted in an increase in the values of adrenocorticotropic hormone (p<0.01) and cortisol (p <0.01) compared with those of children with syndrome of biologically inactive growth hormone before the use of recombinant growth hormone and practically consistent with the reference values.

Conclusions. Syndrome of biologically inactive growth hormone is not accompanied by disorder of the thyrotropic and adenocorticotropic functions of the pituitary gland. Reserve adaptive mechanisms of pituitary-thyroid gland and pituitary-adrenal gland systems have an adequate response to long-term treatment with recombinant growth hormone drugs

Author Biographies

Nataliia Sprynchuk, State Institution “V. P. Komisarenko Institute of Endocrinology and Metabolism of National Academy of Medical Sciences of Ukraine” Vyshhorodska str., 69, Kyiv, Ukraine, 04114 P. L. Shupyk National Medical Academy of Postgraduate Education Dorohozhytska str., 9, Kyiv, Ukraine, 04112

PhD, Senior Researcher, Head of Department

Department of Pediatric Endocrine Pathology

Associate Professor

Department of Endocrinology

Olena Bolshova, State Institution “V. P. Komisarenko Institute of Endocrinology and Metabolism of National Academy of Medical Sciences of Ukraine” Vyshhorodska str., 69, Kyiv, Ukraine, 04114

MD, Professor, Head of the Department

Department of Pediatric Endocrine Pathology

References

  1. Petrova, Zh. V., Evstifeeva, G. Yu., Setko, A. G., Veterkova, Z. A. (2015). Lineynyiy rost kak integralnyiy pokazatel zdorovya (obzor literaturyi) [Linear growth as an integral indicator of health (literature review)]. Orenburgskiy meditsinskiy vestnik, 3 (2), 71–74.
  2. Yakovleva, L. V., Izotova, L. D., Malievskiy, O. A. (2015). Otsenka patologii fizicheskogo razvitiya detey s pozitsii vracha pediatra [Assessment of the pathology of the physical development of children from the perspective of a paediatrician]. Zabaykalskiy meditsinskiy vestnik, 4, 97–105.
  3. Baron, J., Sävendahl, L., De Luca, F., Dauber, A., Phillip, M., Wit, J. M., Nilsson, O. (2015). Short and tall stature: a new paradigm emerges. Nature Reviews Endocrinology, 11 (12), 735–746. doi: http://doi.org/10.1038/nrendo.2015.165
  4. Marwaha, R., Dabas, A., Khadgawat, R., Gahlot, M., Surana, V., Mehan, N. et. al. (2018). Height velocity in apparently healthy north Indian school children. Indian Journal of Endocrinology and Metabolism, 22 (2), 256–260. doi: http://doi.org/10.4103/ijem.ijem_638_17
  5. Ayatollahi, S. M. T., Haem, E., Sharafi, Z. (2015). Growth Velocity of Infants From Birth to 5 Years Born in Maku, Iran. Global Journal of Health Science, 8(2), 56–63. doi: http://doi.org/10.5539/gjhs.v8n2p56
  6. Gutch, M., Kumar, S., Razi, S., Gupta, A., Kumar, S., Gupta, K., Singh, M. (2015). Prevalence of short stature in juvenile hypothyroidism and the impact of treatment on various skeletal manifestation and growth velocity in a teritary care center. CHRISMED Journal of Health and Research, 2 (3), 251–256. doi: http://doi.org/10.4103/2348-3334.158704
  7. Mazziotti, G., Giustina, A. (2013). Glucocorticoids and the regulation of growth hormone secretion. Nature Reviews Endocrinology, 9(5), 265–276. doi: http://doi.org/10.1038/nrendo.2013.5
  8. Vyshnevska, O. A., Bolshova, O. V. (2013). Vplyv zamisnoi terapii prepar atamy rekombinantnoho hormonu rostu na stan hipofizarno-tyreoidnoi ta hipofizarno-nadnyrnykovoi system u ditei prepubertatnoho viku iz somatotropnoiu nedostatnistiu [The effect of replacement therapy with preparations of the recombinant growth hormone on the state of the pituitary-thyroid and pituitary-adrenal systems in prepubertal children with somatotropic insufficiency]. Likarska sprava, 4, 81–87.
  9. Ghaemmaghami, P., Ayatollahi, S. M. T., Alinejad, V., Haem, E. (2015). Longitudinal standards for growth velocity of infants from birth to 4 years born in West Azerbaijan Province of northwest Iran. Epidemiology and Health, 37, e2015029. doi: http://doi.org/10.4178/epih/e2015029
  10. Rose, S. R. (1995). Isolated Central Hypothyroidism in Short Stature. Pediatric Research, 38 (6), 967–973. doi: http://doi.org/10.1203/00006450-199512000-00023
  11. Audí, L., Fernández-Cancio, M., Camats, N., Carrascosa, A. (2013). Growth hormone deficiency: an update. Minerva Endocrinologica, 38 (1), 1–16.
  12. Nielsen, J., Jensen, R. B., Afdeling, A. J. (2015). Growth hormone deficiency in children. Ugeskr Laeger, 177 (26), 1260–1263.
  13. Tronko, M. D. (Ed.) (2010). Dovidnyk likarya-endokrynoloha. Kyiv: TOV «Doktor-Media», 460.
  14. Muscogiuri, G., Mitri, J., Mathieu, C., Badenhoop, K., Tamer, G., Orio, F. et. al. (2014). Mechanisms in endocrinology: Vitamin D as a potential contributor in endocrine health and disease. European Journal of Endocrinology, 171 (3), 101–110. doi: http://doi.org/10.1530/eje-14-0158

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Published

2019-04-02

How to Cite

Sprynchuk, N., & Bolshova, O. (2019). Influence of recombinant growth hormone treatment on the state of pituitary-thyroid and pituitary-adrenal systems in children with syndrome of biologically inactive growth hormone. ScienceRise: Medical Science, (2 (29), 19–22. https://doi.org/10.15587/2519-4798.2019.161763

Issue

No. 2 (29) (2019)

Section

Medical Science

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Copyright (c) 2019 Nataliia Sprynchuk, Olena Bolshova

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