Retrospective evaluation of the effect of long-term use of inhalation glucocorticosteroids on physical development of children and adolescents with bronchial asthma

Authors

  • Kristina Burynyuk-Gloviak Higher State Educational Establishment of Ukraine «Bukovinian State Medical University» Teatralna sq., 2, Chernivtsi, Ukraine, 58002 Municipal Medical Institution "Regional Children's Clinical Hospital" Ruska str., 207 A, Chernivtsi, Ukraine, 58023, Ukraine https://orcid.org/0000-0003-2062-1763
  • Yevheniya Ortemenka Higher State Educational Establishment of Ukraine «Bukovinian State Medical University» Teatralna sqr., 2, Chernivtsi, Ukraine, 58002 Municipal Medical Institution "Regional Children's Clinical Hospital" Ruska str., 207 A, Chernivtsi, Ukraine, 58023, Ukraine https://orcid.org/0000-0003-1794-3921

DOI:

https://doi.org/10.15587/2519-4798.2019.185635

Keywords:

bronchial asthma, children, inhaled glucocorticosteroids, physical development, retrospective analysis

Abstract

The aim of research was to evaluate retrospectively the dose-depended effect of the use of inhaled steroids on the anthropometrical indices of children and adolescents with bronchial asthma.

Material and methods. Based on the pulmonological department of the Regional children clinical hospital in Chernivtsi city there has been conducted the evaluation of the physical development of 50 asthma patients who were under long-term use of inhaled glucocorticosteroids (IGCS). All patients underwent anthropometric study: weight and height measurements with calculation of body mass index (BMI). The assessment of physical development of patients has been performed by a centile method, taking into account the age of patients (using percentile tables "anthropometric indices to age").

Results. Analysis of the data has showed that a patients' height was, on average, 50±4.4 percentile, which was corresponding to the average age-related normative values. At the same time height below (10-25 percentiles) average regarding to the age was recorded in 12 % of all examined patients, but an low (5-10 percentile) or very low (<5 percentiles) height were noted in only 4 patients (6 % and 2 % respectively among all patients). Meanwhile, it has been found that the average BMI in the examined patients was 20.4±0.5 kg/m2, which was corresponding to the normostenic structure. Simultaneously, only 5 of examined patients (10 %) were overweight (BMI> 25 kg/m2), and only one person out them (2 %) had clinically significant (BMI> 30 kg/m2) obesity.

Conclusion. From the perspective of evidence-based medicine, negative impact of the long-term use of IGCS, in medium-high or high doses as well, on growth and body weight of the asthmatic children and adolescents had not been confirmed. At that, statistically significant data on the association of obesity and short stature with prolonged use of medium-high or high doses of IGCS had not been found: the attributive risk of excessive (body mass index> 25 kg/m2) body weight was 24 %, the odd ratio=3.2 (95 % confidence interval: 0.33-30.94), but at the same time the attributive risk of short stature (height <10 percentiles): was 18 % and the odds ratio=2.3 (95 % confidence interval: 0.22-23.88)

Author Biographies

Kristina Burynyuk-Gloviak, Higher State Educational Establishment of Ukraine «Bukovinian State Medical University» Teatralna sq., 2, Chernivtsi, Ukraine, 58002 Municipal Medical Institution "Regional Children's Clinical Hospital" Ruska str., 207 A, Chernivtsi, Ukraine, 58023

Postgraduate Student

Department of Pediatrics and Children Infectious Diseases

Yevheniya Ortemenka, Higher State Educational Establishment of Ukraine «Bukovinian State Medical University» Teatralna sqr., 2, Chernivtsi, Ukraine, 58002 Municipal Medical Institution "Regional Children's Clinical Hospital" Ruska str., 207 A, Chernivtsi, Ukraine, 58023

PhD, Associate Professor

Department of Pediatrics and Children Infectious Diseases

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Published

2019-12-11

How to Cite

Burynyuk-Gloviak, K., & Ortemenka, Y. (2019). Retrospective evaluation of the effect of long-term use of inhalation glucocorticosteroids on physical development of children and adolescents with bronchial asthma. ScienceRise: Medical Science, (6 (33), 26–31. https://doi.org/10.15587/2519-4798.2019.185635

Issue

No. 6 (33) (2019)

Section

Medical Science

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Copyright (c) 2019 Kristina Burynyuk-Gloviak, Yevheniya Ortemenka

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