Interrelations of cytokine production levels in the mechanisms of inflammatory process regulation in patients with community-acquired pneumonia
DOI:
https://doi.org/10.15587/2519-4798.2022.252919Keywords:
community-acquired pneumonia, pathogenesis, cytokines, inflammation, diagnosisAbstract
The aim of study was to study of cytokine production levels and their relationship in the mechanisms of regulation of the inflammatory process in community-acquired pneumonia.
Materials and methods. The study was carried out in the period 2017–2020 based on the therapeutic department of the Municipal non-profit enterprise “City Clinical Multidisciplinary Hospital No. 25” of Kharkiv City Council. The study involved 34 adult patients with CAP aged 18 to 80 years (mean age 36.5±10.3). The control group consisted of 20 apparently healthy individuals (mean age 39.5±12.5). Levels of IL-17, IL-1Ra, TGFβ1, visfatin, adiponectin were determined by enzyme-linked immunosorbent assay.
Results. Levels of IL-1 Ra and IL-17 in the group of patients with САP were 3.77±0.24 and 33.08±0.10 pg/ml, respectively. In the PРI group, the level of these indicators was probably higher (p<0.05) and was 2.53±0.13 and 28.17±0.53 pg/ml. The level of TGFβ1 in the group of patients with CAP was 24.54±0.55 ng/ml and was slightly higher than in the group of AHI (26.33±0.62 ng/ml). No differences were found between adiponectin levels in the AHI group and patients with CAP, as in the case of visfatin levels. The disappearance of relationships in the system of normal regulation of the inflammatory process between one pair of cytokines and their appearance between other pairs indicates a violation of regulatory mechanisms in patients with community-acquired pneumonia.
Conclusions. The identified characteristics of the cytokine profile reflect the end of the phase of active inflammation in the lungs and the beginning of the phase of compensatory reactions. The findings suggest the importance of studying the cytokine profile in patients with community-acquired pneumonia, which will help to develop new approaches to predict the course of pneumonia, ways to correct metabolic disorders that develop in this condition, and will help identify risk groups for this pathology
References
- Eshwara, V., Mukhopadhyay, C., Rello, J. (2020). Community-acquired bacterial pneumonia in adults: An update. Indian Journal of Medical Research, 151 (4), 287–302. doi: http://doi.org/10.4103/ijmr.ijmr_1678_19
- Lanks, C. W., Musani, A. I., Hsia, D. W. (2019). Community-acquired Pneumonia and Hospital-acquired Pneumonia. Medical Clinics of North America, 103 (3), 487–501. doi: http://doi.org/10.1016/j.mcna.2018.12.008
- Huang, Y., Liu, A., Liang, L., Jiang, J., Luo, H., Deng, W. et. al. (2018). Diagnostic value of blood parameters for community-acquired pneumonia. International Immunopharmacology, 64, 10–15. doi: http://doi.org/10.1016/j.intimp.2018.08.022
- Godwin, M. S., Reeder, K. M., Garth, J. M., Blackburn, J. P., Jones, M., Yu, Z. et. al. (2019). IL-1RA regulates immunopathogenesis during fungal-associated allergic airway inflammation. JCI Insight, 4 (21). doi: http://doi.org/10.1172/jci.insight.129055
- Frangogiannis, N. G. (2020). Transforming growth factor–β in tissue fibrosis. Journal of Experimental Medicine, 217 (3). doi: http://doi.org/10.1084/jem.20190103
- Goebel, E. J., Hart, K. N., McCoy, J. C., Thompson, T. B. (2019). Structural biology of the TGFβ family. Experimental Biology and Medicine, 244 (17), 1530–1546. doi: http://doi.org/10.1177/1535370219880894
- Kanazawa, I., Yamaguchi, T., Yano, S., Yamauchi, M., Yamamoto, M., Sugimoto, T. (2007). Adiponectin and AMP kinase activator stimulate proliferation, differentiation, and mineralization of osteoblastic MC3T3-E1 cells. BMC Cell Biology, 8 (1). doi: http://doi.org/10.1186/1471-2121-8-51
- Liu, D., Tan, Y., Bajinka, O., Wang, L., Tang, Z. (2020). Th17/IL-17 Axis Regulated by Airway Microbes Get Involved in the Development of Asthma. Current Allergy and Asthma Reports, 20 (4). doi: http://doi.org/10.1007/s11882-020-00903-x
- Lapach, S. N., Chubenko, A. B., Babich, P. N. (2001). Statisticheskie metody v mediko-biologicheskikh issledovaniiakh s ispolzovaniem Exel. Kyiv: Morion, 408.
- Tu, Q., Zhang, J., Dong, L. Q., Saunders, E., Luo, E., Tang, J., Chen, J. (2011). Adiponectin Inhibits Osteoclastogenesis and Bone Resorption via APPL1-mediated Suppression of Akt1. Journal of Biological Chemistry, 286 (14), 12542–12553. doi: http://doi.org/10.1074/jbc.m110.152405
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Vladyslav Bereznyakov
This work is licensed under a Creative Commons Attribution 4.0 International License.
Our journal abides by the Creative Commons CC BY copyright rights and permissions for open access journals.
Authors, who are published in this journal, agree to the following conditions:
1. The authors reserve the right to authorship of the work and pass the first publication right of this work to the journal under the terms of a Creative Commons CC BY, which allows others to freely distribute the published research with the obligatory reference to the authors of the original work and the first publication of the work in this journal.
2. The authors have the right to conclude separate supplement agreements that relate to non-exclusive work distribution in the form in which it has been published by the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.
