Metabolism and trophological status evaluation of patients with gastric cancer after gastrectomy and subtotal proximal resection of the stomach

Authors

DOI:

https://doi.org/10.15587/2519-4798.2016.84935

Keywords:

gastric cancer, gastrectomy, damping-syndrome, carbohydrate load, creatorrhoea, body mass index

Abstract

Aim. The indices of DT functional state and some indices of metabolism were studied and also trophological status of patients with gastric cancer after gastrectomy (GE) by the new technology of esophageal anastomosis formation was evaluated in the work.

Methods. The research included 150 patients with gastric cancer. In the main group was applied the new technology of esophageal anastomosis formation. In 1, 12 and 24 months after gastroectomy (GE) the test on tolerance to glucose, carbohydrate load and, scatological study were carried out and the body mass index of patients was measured. The clinical data were analyzed using the program software for personal computer: Microsoft Excel et Statistica 6.0. Statictical processing was carried out using Student criterion. The differences were considered as reliable ones at p <0,05. The analysis of clinical data was carried out using the program software for personal computer: Microsoft Excel et Statistica 6.0.

Result. It was established, that in patients of the main group during 2 years after resection of stomach was observed the decrease of number of complaints after carbohydrate load and manifestations of damping syndrome decreased in 2 times. With increase of postoperative term the creatorrhoea manifestations decreased in the main group. Patients with the new variant of reconstruction had better trophological status that is proved by the increase of body mass index.

Conclusions. Thus, the use of the new method of reconstruction of digestive tract at GE significantly increases the trophological state, indices of carbohydrate metabolism and DT functional state in both postoperative and remote terms after GE

Author Biographies

Юрій Олексійович Вінник, Kharkiv Medical Academy of Postgraduate Education Amosova str., 4, Kharkiv, Ukraine, 61070

MD, Professor

Department of cancer surgery

Геннадій Віталійович Трунов, Kharkiv National Medical University, Nauky ave., 4, Kharkiv, Ukraine, 61070

PhD, Associate Professor

Department of Oncology 

Мохамед Саєд Хуссейн Абухассан, Kharkiv Medical Academy of Postgraduate Education Amosova str., 4, Kharkiv, Ukraine, 61070

Postgraduate student

Department of Oncology 

References

  1. Siegel, R., Ma, J., Zou, Z., Jemal, A. (2014). Cancer statistics, 2014. CA: A Cancer Journal for Clinicians, 64 (1), 9–29. doi: 10.3322/caac.21208
  2. Rak v Ukraiyini, 2011–2012. Zakhvoruvanist, smertnist, pokaznyky diyalnosti onkologhichnoiyi sluzhby (2013). Bulleten natsionalnogo cantserogennogo reestru Ukraiyny.
  3. Siplivyj, V. A., Grinchenko, S. V., Evtushenko, D. V. (2011). Jenteral'noe pitanie u hirurgicheskih bol'nyh. Ukrains'kij Zhurnal Hіrurgіi, 3, 50–54.
  4. Kang, Y.-K., Yook, J. H., Chang, H.-M., Ryu, M.-H., Yoo, C., Zang, D. Y. et. al. (2013). Enhanced efficacy of postoperative adjuvant chemotherapy in advanced gastric cancer: results from a phase 3 randomized trial (AMC0101). Cancer Chemotherapy and Pharmacology, 73 (1), 139–149. doi: 10.1007/s00280-013-2332-5
  5. Bakulin, I. G., Novozhenov, V. G. (2003). K voprosu o diagnostike i korrekcii narushenij trofologicheskogo statusa. Voenno-medicinskij zhurnal, 3, 44–47.
  6. Oida, T., Mimatsu, K., Kano, H. et. al. (2012). Advantages of jejunal pouch in Roux- en- Y reconstruction. Hepatogastroenterology, 59 (117), 1647–1650.
  7. Oleksenko, V. V. (2012). Gastrjektomija s formirovaniem kishechnogo rezervuara kak sposob profilaktiki osnovnyh postgastrrezekcionnyh oslozhnenij. Klіnіchna hіrurgіja, 3, 13–17.
  8. Szalek, E., Kaminska, A., Murawa, D., Połom, K., Urbaniak, B., Sobiech, M. et. al. (2011). Comparison of the pharmacokinetics of paracetamol from two generic products in patients after total gastric resection. Pharmacological Reports, 63 (6), 1518–1525. doi: 10.1016/s1734-1140(11)70715-0
  9. Shpata, V., Prendushi, X., Kreka, M., Kola, I., Kurti, F., Ohri, I. (2014). Malnutrition at the Time of Surgery Affects Negatively the Clinical Outcome of Critically Ill Patients with Gastrointestinal Cancer. Medical Archives, 68 (4), 263. doi: 10.5455/medarh.2014.68.263-267
  10. Metel'skij, S. T. (2009). Fiziologicheskie mehanizmy vsasyvanija v kishechnike. Rossijskij zhurnal gastrojenterologii, gepatologii i koloproktologii, 3, 51–56.
  11. Ding, X., Yan, F., Liang, H. et. al. (2013). Mechanism study on intestinal motility of reconstruction procedures after total gastrectomy. Zhonghua Wei Chang Wai Ke Za Zhi., 16, 173–178.
  12. Mamedov, N. G. (2011). Vplyv rann'ogo enteral'nogo zondovogo harchuvannja na bilkovyj i lipidnyj obmin u hvoryh, operovanyh z pryvodu vyrazkovoi' hvoroby ta raku shlunka. Hirurgija Ukrai'ny, 2, 71–74.
  13. Jarema, R. R., Fecych, T. G. (2012). Rak shlunka z vysokym ryzykom intraperytoneal'nogo progresuvannja: faktory ryzyku ta rezul'taty hirurgichnogo likuvannja. Klynycheskaja Onkologyja, 5, 59–62.
  14. Zong, L., Chen, P., Chen, Y., Shi, G. (2011). Pouch Roux-en-Y vs No Pouch Roux-en-Y following total gastrectomy: a meta-analysis based on 12 studies. Journal of Biomedical Research, 25 (2), 90–99. doi: 10.1016/s1674-8301(11)60011-0
  15. Cidon, E. U. (2010). Nutritional Status After Total Gastrectomy for Gastric Cancer. World Journal of Oncology, 1 (2), 87–90. doi: 10.4021/wjon2010.04.196w
  16. Vinnyk, Ju. O., Trunov, G. V., Mohammed, Sajed Hussejn Abu Hassa (2015). Pat. No. 100810. Sposib formuvannja stravohidno-shlunkovogo anastomozu. MPK A61V 17/00 A61V 17/11. No. u201501792; zajavl. 02.03.2015; opubl. 10.08.2015, Byul. № 15, 6.
  17. Vinnyk, Ju. O., Trunov, G. V., Mohammed, Sajed Hussejn Abu Hassan (2015). Pat. No. 98520. Sposib formuvannja stravohidno-shlunkovogo anastomozu pry hirurgichnomu likuvanni raku stravohodu ta shlunku. MPK A61V 17/00. No. u201413207; zajavl. 09.12.2014; opubl. 27.04.2015, Byul. № 8, 8.
  18. Davydov, M. I., Terovanesov, M. D. (2008). Rak proksimal'nogo otdela zheludka: sovremennaja klassifikacija, taktika hirurgicheskogo lechenija, faktory prognoza. Russkij medicinskij zhurnal, 13, 914–920.
  19. Sobin, L. H., Wittekind Ch. (Eds.) (2002). TNM classification of malignant tumours. 6th ed. New York: Wiley-Liss, 239.
  20. Serlin, D. C., Lash, R. W. (2009). Diagnosis and management of gestational diabetes mellitus. American Family Physician, 80 (1), 57–62.
  21. Brehov, E. I., Mizin, S. P., Repin, I. G. (2013). Obosnovanie sposoba vosstanovlenija nepreryvnosti zheludochno-kishechnogo trakta posle rezekcii zheludka. Hirurgija, 6, 8–13.

Published

2016-11-30

How to Cite

Вінник, Ю. О., Трунов, Г. В., & Абухассан, М. С. Х. (2016). Metabolism and trophological status evaluation of patients with gastric cancer after gastrectomy and subtotal proximal resection of the stomach. ScienceRise: Medical Science, (11 (7), 61–70. https://doi.org/10.15587/2519-4798.2016.84935

Issue

Section

Medical Science