Impact of risk factors in developing bronchial asthma combined with gastroesophageal reflux disease in children

Authors

  • T.R. Umanets Institute of Pediatrics, Obstetrics and Gynecology named after academician O. Lukyanova of the National Academy of Medical Sciences of Ukraine Maiborоdy str., 8, Kyiv, 04050, Ukraine https://orcid.org/0000-0001-9058-7383
  • A.A. Buratynska Institute of Pediatrics, Obstetrics and Gynecology named after academician O. Lukyanova of the National Academy of Medical Sciences of Ukraine Maiborоdy str., 8, Kyiv, 04050, Ukraine https://orcid.org/0000-0003-3790-0419
  • S.I. Tolkach Institute of Pediatrics, Obstetrics and Gynecology named after academician O. Lukyanova of the National Academy of Medical Sciences of Ukraine Maiborоdy str., 8, Kyiv, 04050, Ukraine https://orcid.org/0000-0002-9508-7932
  • L.S. Stepanova Institute of Pediatrics, Obstetrics and Gynecology named after academician O. Lukyanova of the National Academy of Medical Sciences of Ukraine Maiborоdy str., 8, Kyiv, 04050, Ukraine https://orcid.org/0000-0001-7296-849X
  • S.Yu. Matveeva Institute of Pediatrics, Obstetrics and Gynecology named after academician O. Lukyanova of the National Academy of Medical Sciences of Ukraine Maiborоdy str., 8, Kyiv, 04050, Ukraine https://orcid.org/0000-0002-1725-650X
  • T.V. Kondratenkova Institute of Pediatrics, Obstetrics and Gynecology named after academician O. Lukyanova of the National Academy of Medical Sciences of Ukraine Maiborоdy str., 8, Kyiv, 04050, Ukraine https://orcid.org/0000-0003-0046-4035
  • O.A. Smirnova Institute of Pediatrics, Obstetrics and Gynecology named after academician O. Lukyanova of the National Academy of Medical Sciences of Ukraine Maiborоdy str., 8, Kyiv, 04050, Ukraine https://orcid.org/0000-0002-8338-7161
  • T.A. Garaschenko Institute of Pediatrics, Obstetrics and Gynecology named after academician O. Lukyanova of the National Academy of Medical Sciences of Ukraine Maiborоdy str., 8, Kyiv, 04050, Ukraine https://orcid.org/0000-0002-6086-7795
  • V.F. Lapshyn Institute of Pediatrics, Obstetrics and Gynecology named after academician O. Lukyanova of the National Academy of Medical Sciences of Ukraine Maiborоdy str., 8, Kyiv, 04050, Ukraine https://orcid.org/0000-0003-1896-1865
  • Yu.G. Antipkin Institute of Pediatrics, Obstetrics and Gynecology named after academician O. Lukyanova of the National Academy of Medical Sciences of Ukraine Maiborоdy str., 8, Kyiv, 04050, Ukraine https://orcid.org/0000-0002-8018-4393

DOI:

https://doi.org/10.26641/2307-0404.2020.4.221399

Keywords:

children, asthma, gastroesophageal reflux disease, risk factors

Abstract

The purpose of the study was to determine the risk factors affecting the development of asthma combined with gastroesophageal reflux disease (GERD). Seventy children aged 5-17 years with asthma were examined. They were divided to two groups: group 1 (50 children with asthma and GERD), and group 2 (20 children with isolated asthma). Medical history data were collected through specially designed questionnaire for parents. It was determined that the perinatal risk factors that likely contributed to developing co-morbid asthma and GERD were a threatened miscarriage (OR=6.65; 95% CI, 1.7-25.6, p=0.003), acute respiratory illnesses during pregnancy (OR=6.52; 95% CI, 1.4-31.2, p=0.008), polyhydramnios (p=0.039) and uterine inertia (p=0.0003). Food hypersensitivity in the first year of life, the severity of asthma in examined children played role in increasing the risk of developing asthma combined with GERD (OR=4.83; 95% CI, 1.3-18.6, p=0.013 and OR=4.45; 95% CI, 1.2-17.1, р=0.019 respectively).

References

Bolbot YuK, Kalichevskaya MV. [Risk factors of the pathology development the upper digestive tract in chil­dren with asthma]. Zdorov’e rebenka. 2015;3(62):40-43. Ukrainian. Available from: http://nbuv.gov.ua/UJRN/Zd_2015_3_10

[Recommendations of the Bioethics Committee under the Presidium of the National Academy of Medical Sciences of Ukraine]. NAMS of Ukraine. 2002;18. Ukrainian.

Belousova OYu, Slobodianiuk OL, Pavlenko NV, Hanzii OB, Voloshyn KV. [Risk factors and possibilities of preventing gastroesophageal reflux disease in school-age children]. Zdorov’e rebenka. 2018;13(Suppl 1):S73-8. Ukrainian.

doi: https://doi.org/10.22141/2224-0551.13.0.2018.131183

Convention on Human Rights and Biomedicine. Available from: https://www.coe.int/en/web/conventions/full-list/-/conventions/rms/090000168007d004

Ethical Principles for Medical Research In­volving Human subjects: Declaration of Helsinki / World Medical Association. JAMA. 2013;310(20):2191-4. doi: https://doi.org/10.1001/jama.2013.281053

Bongiovanni A, Parisi GF, Scuderi MG, Licari A, Brambilla I, Marseglia GL, Leonardi S. Gastroesophageal Reflux and Respiratory Diseases: Does a Real Link Exist? Minerva Pediatrica. December 2019;71(6):515-23. doi: https://doi.org/10.23736/S0026-4946.19.05531-2

Dahlen HG, Foster JP, Psaila K, Spence K, et al. Gastro-oesophageal reflux: a mixed methods study of infants admitted to hospital in the first 12 months following birth in NSW (2000–2011). BMC Pediatr. 2018;18:30. doi: https://doi.org/10.1186/s12887-018-0999-9

Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention; 2018. Available from: www.ginasthma.org

Hunt Richard, Armstrong David, Peter Ka­telaris, Afihene Mary et al. World Gastroenterology Organisation Global Guidelines. Global Perspective on Gastroesophageal Reflux Disease. Journal of Clinical Gastroenterology. July 2017;51.6:467-78. doi: https://doi.org/10.1097/MCG.0000000000000854

Lodge CJ, Tan DJ, Lau MXZ, Dai X. Breast­feeding and asthma and allergies: a systematic review and meta‐analysis. Acta Pædiatrica. 2015;104:38–53. doi: https://doi.org/10.1111/apa.13132

Bolan Yu, Lijuan Dai, Juanjuan Chen, et al. Prenatal and neonatal factors involved in the development of childhood allergic diseases in Guangzhou primary and middle school students. BMC Pediatrics. 2019;19:479. doi: https://doi.org/10.1186/s12887-019-1865-0

Matheson MC, DO AL, Burgess JA, Giles GG, Hopper JL, Johns DP, Abramson MJ, Walters EH, Dhar­mage SC. Preterm birth and low birth weight con­tinue to increase the risk of asthma from age 7 to 43. J Asth­ma. 2017;54(6):616-23. doi: https://doi.org/10.1080/02770903.2016.1249284

Rusconi F, Zugna D, Annesi-Maesano I, Baïz N. Mode of Delivery and Asthma at School Age in 9 European Birth Cohorts. American Journal of Epidemiology. 2017;185:6. doi: https://doi.org/10.1093/aje/kwx021

Published

2020-12-28

How to Cite

1.
Umanets T, Buratynska A, Tolkach S, Stepanova L, Matveeva S, Kondratenkova T, Smirnova O, Garaschenko T, Lapshyn V, Antipkin Y. Impact of risk factors in developing bronchial asthma combined with gastroesophageal reflux disease in children. Med. perspekt. [Internet]. 2020Dec.28 [cited 2024Dec.25];25(4):121-7. Available from: https://journals.uran.ua/index.php/2307-0404/article/view/221399

Issue

Vol. 25 No. 4 (2020)

Section

CLINICAL MEDICINE

License

Copyright (c) 2020 Medicni perspektivi (Medical perspectives)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Submitting manuscript to the journal "Medicni perspektivi" the author(s) agree with transferring copyright from the author(s) to publisher (including photos, figures, tables, etc.) editor, reproducing materials of the manuscript in the journal, Internet, translation into other languages, export and import of the issue with the author’s article, spreading without limitation of their period of validity both on the territory of Ukraine and other countries. This and other mutual duties of the author and all co-authors separately and editorial board are secured by written agreement by special form to use the article, the sample of which is presented on the site.

Author signs a written agreement and sends it to Editorial Board simultaneously with submission of the manuscript.