Age aspect of adaptive response of the central nervous system in the state of emotional pain.
DOI:
https://doi.org/10.26641/2307-0404.2014.4.35588Keywords:
spontaneous behavioral activity, spatial memory, unsaturated fatty acids, hippocampus, neocortexAbstract
The formation of higher adaptive response in the postoperative period was investigated in experiments on rats of two age groups. It was found inhibition of the orientation-motor and emotional activity in young (5-6 months) and old rats (20-24 months) with the greatear effect in animals of the first age group. In young rats the inhibition of spatial memory was observed – number of food-getting depleted reactions decreased by 28%. Cognitive deficit was accompanied by opposite changes in the content of free unsaturated fatty acids (C18: 2.3), respectively to age features: decreased by 46% in the cortex of young rats and increased by 2.5-fold in the hippocampus of old animals.References
Буреш Я. Методики и основные эксперименты по изучению мозга и поведения / Я. Буреш, О. Буре¬шова, Д. Хьюстон.–М.: Высшая школа, 1991 .– С.175 – 188, 119-122.
Генетические основы предрасположенности к паническому расстройству / Л.А. Коробейников, О.И. Рудь¬ко, Ю.Э. Азимова [и др.] // Успехи соврем. биологии. – 2012. – Т.123, №1. – С. 21-35.
Кокунин В.А. Статистическая обработка дан¬ных при малом числе опытов / В.А. Кокунин // Укр. биохим. журнал. – 1975. – Т. 47, № 6.– С. 776-791.
Концентрация серотонина и его метаболита 5-гидроксииндолуксусной кислоты в структурах мозга крыс линии Вистар и Way/Rij, влияние имипрамина на пик-волновую активность / И.С. Мидзяновская, А.А. Фоломкина, О.Х. Коштоянц [и др.] // Нейрохимия. – 2010. – Т. 27, №3. – С. 238-244.
Кульчицкий О.К. Особенности пероксидного окисления липидов в тканях головного мозга и печени старых крыс при стрессе / О.К. Кульчицкий, Р.И. По¬та¬пенко, С.Н. Новикова // Укр. біохім. журнал. – 2001. – Т. 73. – № 4. – С. 73-78.
Прохорова М.И. Методы биохимических ис¬следо¬ваний (липидный и энергетический обмен) / М.И. Прохорова. – Л.: Изд-во Ленингр. ун-та, 1982. – 250 с.
Спроба системного підходу до оцінки хірур¬гіч¬ного стресу і порушення серцевої функції / О.В. Бє¬ляков, В.Т. Селиваненко, О.О. Свірський [та ін.] // Одес. мед. журнал. − 2005. − № 6 (97). − С.89-92.
Становление в филогенезе липопротеинов низ¬кой и очень низкой плотности и инсулина. Липо¬ток¬сичность жирных кислот и липидов. Позиционные изомеры триглицеридов / В.Н. Титов, И.А. Востров, Ю.К. Ширяева [и др.] // Успехи соврем. биологии. – 2012. – Т.132, № 5. – С. 506-526.
Уровень моноаминов и их метаболитов в структурах мозга крыс с экспериментальным тревож¬но-депрессивным состоянием, вызванным введением ингибитора дипептидилпептидазы IV в раннем постнатальном периоде / Е.Ю. Кушнарева, Н.А. Крупина, Н.Н. Хлебникова [и др.] // Нейрохирургия. – 2012. – Т. 29, № 2. – С. 139 – 144.
Ярош А.К. Нейрофармакологический анализ функционирования ЦНС в динамике послеопера¬цион¬ного состояния и экспериментальное обоснование его коррекции: автореф. дис.: на соискание учен. степени д-ра. мед. наук.: спец. 14.00.25 "Фармакология" / А.К. Ярош – К., 1991. – 34 с.
Almeida P.F.F. Thermodynamics of lipid inter¬action in complex bilayers / P.F.F. Almedia // Biohim. Biophіs. Acta. – 2009. – Vol. 1788. – P.72-85.
An out look on organization of lipids in mem¬branеs: searching for a realistic: connection with the organisation of biological membranеs / L.A. Bagatolli, J.H. Ipsen, A.C. Simonsen [et al.] // Prog. Lipion Res. – 2010. – Vol. 49. – P.378-389.
D1butnotD5dlopaminereceptorsarecriticalforLTP, spatiallearningandLTP inducedareandzif 268 expres¬sion¬in¬thehippocampus / N.Granado, O. Ortiz, L.M. Suarrez [et al.] // Cerebral. Cortex. – 2008.– Vol. 18. – P. 1-12.
Simons K. Membrane organization and lipid rafts / K. Simons, J.L. Sampaio // Cold Spring Нarb. Perspect. Biol. – 2011. – N 3. – a004697.
REFERENCES
Buresh Ja, Bureshova O, Hjuston D. [Methods and basic experiments on study of brain and behavior]. Vys¬shaja shkola, 1991;175-88, 119-22. Russian.
Korobeynikov LA, Rud'ko OI, Azimovа JE. [Ge¬netic basis of susceptibility to panic disorder]. Uspehi sovremennoy biologii. 2012;123(1):21-35. Russian.
Kokunin VA. [Statistical processing of data in a small number of experiences]. Ukr. biohim. jornal. 1975;47(6):776-91. Russian.
Midzyanovskaya IS, Folomkina AA, Kosh¬toyants OH. [The concentration of serotonin and 5-hydro¬xyindoleacetic acid in structures of rats brain]. Nejro¬himija. 2010;27(3):238-44. Russian.
Kulchitskiy OK, Potapenko RI, Novikova SN [Features of lipid peroxidation in the tissues of brain and liver of old rats under stress]. Ukr. bіohіm. jornal. 2001;73(4):73-78. Ukrainian.
Prohorova MI. [Methods of biochemical re¬searches (lipid and energic exchange)]. Izd-vo Leningrad. 1982;250. Russian.
Byelyakov OV, Selyvanenko VT, Svirskyy OO. [At¬tempt of systematic approach to the evaluation of surgical stress and disorder of cardiac function]. Odes. med. jornal. 2005;97(6):89-92. Ukrainian.
Titov VN, Vostrov IA, Shiryaeva UK. [Formation of low (and very low) density lipoproteins lipoproteids and insulin in phylogenesis. Lipotoxicity of fatty acids and lipids. Positional isomers of triglycerides]. Uspehi sovremennoy biologii. 2012;132(5):506-26. Russian.
Kushnareva EY, Krupina NA, Hlebnikova NN. [Level of monoamines and their metabolites in the brain structures of rats with experimental anxiety and dep¬ression caused by the introduction of dipeptidyl peptidase IV in the early postnatal period]. Nejrochirurgija. 2012;29(2):139-44. Russian.
Yarosh AK. [Neuropharmacological analysis of functioning of the central nervous system in the dynamics of post-operative condition and experimental sub¬stan¬tiation of its correction. Doctor degree. honey. Sciences: spec. 14.00.25 "Pharmacology"]. K. 1991;34. Ukrainian.
Almeida PFF. Thermodynamics of lipid inter¬ac¬tion in complex bilayers.2009;1788:72-85.
Bagatolli LA, Ipsen JH, Simonsen AC. An out look on organization of lipids in membranеs: searching for a realistic: connection with the organisation of biolo¬gical membranеs. 2010;49:378-89.
Granado N, Ortiz O, Suarrez LM. D1butnot D5 dlopamine receptor sarecritical for LTP, spatiallearning and LTP inducedareandzif 268 expressioninthehippocampus. 2008;18:1-12.
Simons K, Sampaio JL. Membrane organization and lipid rafts 2011;3:a004697.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2017 Medical Perspectives
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Submitting manuscript to the journal "Medicni perspektivi" the author(s) agree with transferring copyright from the author(s) to publisher (including photos, figures, tables, etc.) editor, reproducing materials of the manuscript in the journal, Internet, translation into other languages, export and import of the issue with the author’s article, spreading without limitation of their period of validity both on the territory of Ukraine and other countries. This and other mutual duties of the author and all co-authors separately and editorial board are secured by written agreement by special form to use the article, the sample of which is presented on the site.
Author signs a written agreement and sends it to Editorial Board simultaneously with submission of the manuscript.