Features of the autonomic nervous system in children with gastroesophageal reflux disease and different genotypes of C825t locus of Gnb3 gene

Authors

  • Marta Dats-Opoka Danylo Halytskyy Lviv National Medical University Pekarska str., 69, Lviv, Ukraine, 79010, Ukraine https://orcid.org/0000-0002-2797-2462
  • Oleg Hnateyko Danylo Halytskyy Lviv National Medical University Pekarska str., 69, Lviv, Ukraine, 79010 State Institution «Institute of Hereditary Pathology Ukrainian National Academy of Medical Sciences» Lysenka str., 31-a, Lviv, Ukraine, 79008, Ukraine https://orcid.org/0000-0003-0587-659X
  • Halyna Makukh State Institution «Institute of Hereditary Pathology Ukrainian National Academy of Medical Sciences» Lysenka str., 31-a, Lviv, Ukraine, 79008, Ukraine https://orcid.org/0000-0001-7749-5353

DOI:

https://doi.org/10.15587/2519-4798.2017.109148

Keywords:

gastroesophageal reflux disease, children, autonomous (vegetative) nervous system, С825Т, GNB3 polymorphism

Abstract

Aim. To establish features of activity of different links of the autonomous nervous system in children with gastroesophageal reflux disease and different genotype of C825T  locus of GNB3 gene.

Materials and methods. There was realized the analysis of clinical features of GERD and functioning of the autonomous nervous system in 100 schoolchildren. The molecular-genetic study of C825T locus of GNB3 gene using PCR (rs5443) was carried out in the studied group (100 children) and in 40 healthy children, who formed the control group.

Results. Sympathectomy was observed in 47 children (47%), vagotonia in 43 (43%), and euhonia was observed in 10 children (10%). Most patients with sympathectomy demonstrated normo- and hypacidity. Practically all patients with vagotonia demonstrated hyperacidity of the stomach contents.

Among patients with hyperacidity (pH 0,86-1,59) the one third had СС genotype of C825T locus of GNB3 gene and persons with ТТ genotype were absent, whereas in the group of children with normo- and hypoacidity (pH 1,60-3,59)in 25% of patients was revealed ТТ genotype.

Patients with СС genotype of C825T locus of GNB3 gene demonstrated vagotonia essentially more often (67,44%), and ТТ genotype was most often revealed in patients with eutonia (10%), (р<0,05).

Conclusions.

1). The depth of esophagus lesions is not associated with the predominance of one link of the autonomous nervous system, (р>0,05).

2). Hyperacidity in children with GERD is associated with vagotonia.

3). СС genotype of C825T locus of GNB3 gene is associated with vagotonia and hyperacidity, (р<0,05)

Author Biographies

Marta Dats-Opoka, Danylo Halytskyy Lviv National Medical University Pekarska str., 69, Lviv, Ukraine, 79010

Assistant

Department of propedeutics of pediatrics and medical genetics

Oleg Hnateyko, Danylo Halytskyy Lviv National Medical University Pekarska str., 69, Lviv, Ukraine, 79010 State Institution «Institute of Hereditary Pathology Ukrainian National Academy of Medical Sciences» Lysenka str., 31-a, Lviv, Ukraine, 79008

MD, Professor

Department of propedeutics of pediatrics and medical genetics

Director

Halyna Makukh, State Institution «Institute of Hereditary Pathology Ukrainian National Academy of Medical Sciences» Lysenka str., 31-a, Lviv, Ukraine, 79008

Head of Laboratory

Genetic Research Laboratory

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Published

2017-08-31

How to Cite

Dats-Opoka, M., Hnateyko, O., & Makukh, H. (2017). Features of the autonomic nervous system in children with gastroesophageal reflux disease and different genotypes of C825t locus of Gnb3 gene. ScienceRise: Medical Science, (8 (16), 10–15. https://doi.org/10.15587/2519-4798.2017.109148

Issue

No. 8 (16) (2017)

Section

Medical Science

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Copyright (c) 2017 Marta Dats-Opoka, Oleg Hnateyko, Halyna Makukh

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