The trigger meaning of persistent intracellular pathogens with prolonged fever and subsequent development of somatic pathology in children
Keywords:intracellular pathogens, intracellular infection, interleukins, local protective factors, somatic pathology
Despite the intense study of intracellular infections, the data as to their clinical-diagnostic and prognostic value still contradictory, especially in children of young age. Especially, prolonged fevers (fevers of an obscure generation) may be the manifestation of a series of infectious and somatic diseases with the further formation of a chronic somatic pathology.
The interest to this problem is connected, from the one side, with the necessity to prognosticate, early detect and primarily prevent a somatic pathology, forming groups of the high risk. From the other side, the possibility of transformation of an acute pathology in children in a chronic somatic pathology in adults is well-known.
The aim of the research was to improve the diagnostics of the infectious pathology, caused by intracellular pathogens in children, especially at prolonged fevers (fevers of an obscure generation), by improving the diagnostics quality, based on the deepened study of clinical-pathogenetic features of these pathological states.
Methods. There was realized the clinical and laboratory examination of 100 children with prolonged fevers (fevers of an obscure generation), admitted without a set diagnosis. The etiological interpretation was realized by the methods of serological markers (ELISA) and molecular-genetic ones (polymerase chain reaction). The interpretation of levels of blood interleukins was realized by IEA, using ProCon IL-1β, 4, 6, TNF-α, interferon-γ reagents.
As a result of etiological pathogens verification, there were revealed beta-hemolytic streptococcus, virus of simple herpes of 1, 2 types, cytomegalovirus Epstein-Barr, chlamydiosis, mycoplasma, adenoviruses as both mono- and mixed infections. According to the research results, 90% of children demonstrated the high severity and changed status of cytokines and local protective factors. More serious disorders of the immune system are revealed at mixed viral and atypical infections and somatic diseases. Different disorders of the autoimmune mechanism of development, namely system diseases of the connective tissue can appear in children with different variants of intracellular infections.
Conclusions. Clinical-anamnestic, laboratory conclusions and immunologic research using the system analysis allow to prognosticate results in the catamnesis of children with intracellular infections of different somatic pathologies, and the multi-vector and correlation analysis allow to elaborate new diagnostic criteria
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