Gastroesophageal reflux disease in patients with various comorbidal pathology

Authors

DOI:

https://doi.org/10.15587/2519-4798.2020.220010

Keywords:

gastroesophageal reflux disease, extraesophageal manifestations, proton pump inhibitors

Abstract

The aim of the work – conduct a literature review to study the most important and complex aspects in the diagnosis and treatment of gastroesophageal reflux disease that are encountered in the practice of a family doctor.

Results. Gastroesophageal reflux disease is becoming an increasingly important disease for the young and able-bodied population, which gives it not only a medical, but also an economic aspect. This is one of the most common pathologies in the practice of not only a therapist, family doctor and gastroenterologist, but – due to the presence of extraesophageal manifestations – in a wider range of medical specialties. Since gastroesophageal reflux disease has many “masks”, this leads to delayed diagnosis and treatment. This disease does not have a “gold standard” in routine diagnostics, and the presence of its refractory forms leads to treatment failures and complications. With a comorbid course of gastroesophageal reflux disease, both diagnosis and treatment require an integrated approach.

Conclusions. Gastroesophageal reflux disease remains one of the most common diseases in the practice of a family doctor. Despite the extensive study of this pathology, it continues to remain difficult in terms of diagnosis and treatment, which is associated with the presence of extraesophageal manifestations, comorbid and refractory course. This requires an additional study of pathogenetic mechanisms and the development of therapeutic and diagnostic measures on the basis of this

Author Biographies

Aleksey Oparin, Kharkiv Medical Academy of Postgraduate Education Amosova str., 58, Kharkiv, Ukraine, 61176

MD, Professor

Department of Therapy, Rheumatology and Clinical Pharmacology

Anna Titkova, Kharkiv Medical Academy of Postgraduate Education Amosova str., 58, Kharkiv, Ukraine, 61176

PhD, Associate Professor

Department of General Practice-Family Medicine

Kostiantyn Stepanchenko, Kharkiv Medical Academy of Postgraduate Education Amosova str., 58, Kharkiv, Ukraine, 61176

MD, Professor

Department of Neuropathology and Neurosurgery

Vira Tseluyko, Kharkiv Medical Academy of Postgraduate Education Amosova str., 58, Kharkiv, Ukraine, 61176

MD, Professor

Department of Cardiology and Functional Diagnostics

Maryna Kochuieva, Kharkiv Medical Academy of Postgraduate Education Amosova str., 58, Kharkiv, Ukraine, 61176

MD, Professor

Department of Tuberculosis, Pulmonology and Family Medicine

Oleksii Korzh, Kharkiv Medical Academy of Postgraduate Education Amosova str., 58, Kharkiv, Ukraine, 61176

MD, Professor

Department of General Practice-Family Medicine

References

  1. Shcherbynina, M. (2013). Hastroezofahealna refliuksna khvoroba. Kyiv: Medknyha, 105.
  2. Eusebi, L. H., Ratnakumaran, R., Yuan, Y., Solaymani-Dodaran, M., Bazzoli, F., Ford, A. C. (2017). Global prevalence of, and risk factors for, gastro-oesophageal reflux symptoms: a meta-analysis. Gut, 67 (3), 430–440. doi: http://doi.org/10.1136/gutjnl-2016-313589
  3. Zviahintseva, T. D., Serhiienko, O. I., Chernobai, A. I., Sharhorod, I. I., Hridnieva, S. V. (2017). Hastroezofahealna refliuksna khvoroba ta yii refrakterna forma: suchasni uiavlennia pro diahnostyku i likuvannia. Kharkiv: Drukarnia Madryd, 109.
  4. Guan, X.-L., Wang, H. (2015). Quality of life scales for patients with gastroesophageal reflux disease: A literature review. International Journal of Nursing Sciences, 2 (1), 110–114. doi: http://doi.org/10.1016/j.ijnss.2015.02.003
  5. El-Serag, H. B., Sweet, S., Winchester, C. C., Dent, J. (2013). Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut, 63 (6), 871–880. doi: http://doi.org/10.1136/gutjnl-2012-304269
  6. Yamasaki, T., Hemond, C., Eisa, M., Ganocy, S., Fass, R. (2018). The Changing Epidemiology of Gastroesophageal Reflux Disease: Are Patients Getting Younger? Journal of Neurogastroenterology and Motility, 24 (4), 559–569. doi: http://doi.org/10.5056/jnm18140
  7. Kim, G. H. (2018). It Is Time to Meet the Challenges of the Changing Epidemiology of Gastroesophageal Reflux Disease. Journal of Neurogastroenterology and Motility, 24 (4), 507–509. doi: http://doi.org/10.5056/jnm18152
  8. Bordbar, G., Bolandnazar, N. S. (2015). Gastroesophageal reflux disease (GERD): prevalence and association with Psychological Disorders among medical sciences students. International journal of pharmtech research, 8 (7), 120–130.
  9. Rybak, A., Pesce, M., Thapar, N., Borrelli, O. (2017). Gastro-Esophageal Reflux in Children. International Journal of Molecular Sciences, 18 (8), 1671. doi: http://doi.org/10.3390/ijms18081671
  10. Poddar, U. (2018). Gastroesophageal reflux disease (GERD) in children. Paediatrics and International Child Health, 39 (1), 7–12. doi: http://doi.org/10.1080/20469047.2018.1489649
  11. Boeckxstaens, G., El-Serag, H. B., Smout, A. J. P. M., Kahrilas, P. J. (2014). Symptomatic reflux disease: the present, the past and the future. Gut, 63 (7), 1185–1193. doi: http://doi.org/10.1136/gutjnl-2013-306393
  12. Hatemi, I., Esatoglu, S. N. (2017). What is the long term acid inhibitor treatment in gastroesophageal reflux disease? What are the potential problems related to long term acid inhibitor treatment in gastroesophageal reflux disease? How should these cases be followed? The Turkish Journal of Gastroenterology, 28 (1), 57–60. doi: http://doi.org/10.5152/tjg.2017.15
  13. Lee, S. P., Sung, I.-K., Kim, J. H., Lee, S.-Y., Park, H. S., Shim, C. S. (2016). The Clinical Features and Predisposing Factors of Asymptomatic Erosive Esophagitis. Digestive Diseases and Sciences, 61 (12), 3522–3529. doi: http://doi.org/10.1007/s10620-016-4341-9
  14. Pan, J., Cen, L., Chen, W., Yu, C., Li, Y., Shen, Z. (2018). Alcohol Consumption and the Risk of Gastroesophageal Reflux Disease: A Systematic Review and Meta-analysis. Alcohol and Alcoholism, 54( 1), 62–69. doi: http://doi.org/10.1093/alcalc/agy063
  15. An, J., Gharahkhani, P., Law, M. H., Ong, J.-S. et. al. (2019). Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases. Nature Communications, 10 (1). doi: http://doi.org/10.1038/s41467-019-11968-2
  16. Wang, X., T., Zhang, M., Chen, C., Y., Lyu, B. (2016). Helicobacter pylori eradication and gastroesophageal reflux disease: a Meta-analysis, 1 (55 (9)), 710–716. doi: http://doi.org/10.3760/cma.j.issn.0578-1426.2016.09.011
  17. Kseneva, S. I., Borodulina, E. V., Udut, V. V. (2018). Discoordination of Autonomic Support of Functions in the Pathogenesis Gastroesophageal Reflux Disease. Bulletin of Experimental Biology and Medicine, 166 (1), 19–21. doi: http://doi.org/10.1007/s10517-018-4279-3
  18. Ferracioli-Oda, E., Qawasmi, A., Bloch, M. H. (2013). Meta-Analysis: Melatonin for the Treatment of Primary Sleep Disorders. PLoS ONE, 8 (5), e63773. doi: http://doi.org/10.1371/journal.pone.0063773
  19. Yarantseva, N. A. (2020). Clinical-pathogenetic parallels in the combined course of autoimmune tyreoiditis and gastroesophageal reflux disease among young adults. Shidnoevropejskij Zurnal Vnutrisnoi Ta Simejnoi Medicini, 1, 106–110. doi: http://doi.org/10.15407/internalmed2020.01.106
  20. Oparin, O. A., Oparin, A. G., Kudriavtsev, A. A. (2019). The role of grelin in the formation of the comorbide flow of gastroesophageal reflux disease with type 2 diabetes in young people. Problems of Uninterrupted Medical Training and Science, 3, 48–56. doi: http://doi.org/10.31071/promedosvity2019.03.048
  21. Korniienko, D., Oparin, A. (2016). The use of ultrasound methods for the diagnosis of motor and evacuation disorders in gastroesophageal reflux disease with concomitant obesity. Oxford Review of Education and Science, 1 (11), 414–419.
  22. Okuyama, M., Takaishi, O., Nakahara, K., Iwakura, N., Hasegawa, T., Oyama, M. et. al. (2016). Associations among gastroesophageal reflux disease, psychological stress, and sleep disturbances in Japanese adults. Scandinavian Journal of Gastroenterology, 52 (1), 44–49. doi: http://doi.org/10.1080/00365521.2016.1224383
  23. Wu, Z.-H., Yang, X.-P., Niu, X., Xiao, X.-Y., Chen, X. (2018). The relationship between obstructive sleep apnea hypopnea syndrome and gastroesophageal reflux disease: a meta-analysis. Sleep and Breathing, 23 (2), 389–397. doi: http://doi.org/10.1007/s11325-018-1691-x
  24. Voutilainen, M. (2016). Nastanova 00170. Gastroezofagealna refliuksna khvoroba. 18.11.2016. Available at: https://guidelines.moz.gov.ua/?fbclid=IwAR3Lz_a3yd8Y0r9a-HVVb7M33U1emjSh_VJ9gFcpl7BUCgAinIuSSEPTie0
  25. Leason, S. R., Barham, H. P., Oakley, G., Rimmer, J., DelGaudio, J. M., Christensen, J. M. et. al. (2017). Association of gastro-oesophageal reflux and chronic rhinosinusitis: systematic review and meta-analysis. Rhinology Journal, 55 (1), 3–16. doi: http://doi.org/10.4193/rhino16.177
  26. Sidhwa, F., Moore, A., Alligood, E., Fisichella, P. M. (2017). Diagnosis and Treatment of the Extraesophageal Manifestations of Gastroesophageal Reflux Disease. Annals of Surgery, 265 (1), 63–67. doi: http://doi.org/10.1097/sla.0000000000001907
  27. Guo, Z., Wu, H., Jiang, J., Zhang, C. (2018). Pepsin in Saliva as a Diagnostic Marker for Gastroesophageal Reflux Disease: A Meta-Analysis. Medical Science Monitor, 24, 9509–9516. doi: http://doi.org/10.12659/msm.913978
  28. Ahmadi, B., Alimohammadian, M., Yaseri, M., Majidi, A., Boreiri, M., Islami, F., Malekzadeh, R. (2016). Multimorbidity: Epidemiology and risk factors in the golestan cohort study, Iran a cross-sectional analysis. Medicine, 95 (7), e2756. doi: http://doi.org/10.1097/md.0000000000002756
  29. Broers, C., Tack, J., Pauwels, A. (2017). Review article: gastro-oesophageal reflux disease in asthma and chronic obstructive pulmonary disease. Alimentary Pharmacology & Therapeutics, 47 (2), 176–191. doi: http://doi.org/10.1111/apt.14416
  30. Kim, S. Y., Min, C., Oh, D. J., Choi, H. G. (2019). Bidirectional Association Between GERD and Asthma: Two Longitudinal Follow-Up Studies Using a National Sample Cohort. The Journal of Allergy and Clinical Immunology: In Practice, 8 (3), 1005–1013.e9. doi: http://doi.org/10.1016/j.jaip.2019.10.043
  31. Sakitani, K., Suzuki, N., Ihara, S., Hirata, Y., Kawazu, S., Iwamoto, Y., Koike, K. (2018). Decline in perception of acid regurgitation symptoms from gastroesophageal reflux disease in diabetes mellitus patients. PLOS ONE, 13 (3), e0194466. doi: http://doi.org/10.1371/journal.pone.0194466
  32. Drozd, V. Y., Khukhlina, O. S., Mandryk, O. E., Hryniuk, О. Е. (2016). Certain unsolved questions of pathogenetic interrelation between gastroesophageal reflux disease and chronic forms of ischemic heart disease (review of the references). Bukovinian Medical Herald, 20 (2 (78)), 191–193. doi: http://doi.org/10.24061/2413-0737.xx.2.78.2016.106
  33. Su, V. Y.-F., Liao, H.-F., Perng, D.-W., Chou, Y.-C., Hsu, C.-C., Chou, C.-L. et. al. (2018). Proton pump inhibitors use is associated with a lower risk of acute exacerbation and mortality in patients with coexistent COPD and GERD. International Journal of Chronic Obstructive Pulmonary Disease, 13, 2907–2915. doi: http://doi.org/10.2147/copd.s157761
  34. Maev, I., V., Iurenev, G., L., Kakhramanova D., A. (2012). Peculiarities of gastroesophageal reflux disease in patients with type 2 diabetes mellitus. Klin Med, 90 (9), 53–56.
  35. Chen, C.-H., Lin, C.-L., Kao, C.-H. (2016). Association between gastroesophageal reflux disease and coronary heart disease. Medicine, 95 (27), e4089. doi: http://doi.org/10.1097/md.0000000000004089
  36. Parsel, S. M., Wu, E. L., Riley, C. A., McCoul, E. D. (2019). Gastroesophageal and Laryngopharyngeal Reflux Associated With Laryngeal Malignancy: A Systematic Review and Meta-analysis. Clinical Gastroenterology and Hepatology, 17 (7), 1253–1264. doi: http://doi.org/10.1016/j.cgh.2018.10.028
  37. Qumseya, B. J., Bukannan, A., Gendy, S., Ahemd, Y., Sultan, S., Bain, P. et. al. (2019). Systematic review and meta-analysis of prevalence and risk factors for Barrett’s esophagus. Gastrointestinal Endoscopy, 90 (5), 707–717.e1. doi: http://doi.org/10.1016/j.gie.2019.05.030
  38. Yang, Y., Wu, H., Zhou, J. (2016). Efficacy of acid suppression therapy in gastroesophageal reflux disease-related chronic laryngitis. Medicine, 95 (40), e4868. doi: http://doi.org/10.1097/md.0000000000004868
  39. Richter, J. E., Kumar, A., Lipka, S., Miladinovic, B., Velanovich, V. (2018). Efficacy of Laparoscopic Nissen Fundoplication vs Transoral Incisionless Fundoplication or Proton Pump Inhibitors in Patients With Gastroesophageal Reflux Disease: A Systematic Review and Network Meta-analysis. Gastroenterology, 154 (5), 1298–1308. doi: http://doi.org/10.1053/j.gastro.2017.12.021
  40. Bashir, Y., Chonchubhair, H. N., Duggan, S. N., Memba, R., Ain, Q. ul, Murphy, A. et. al. (2019). Systematic review and meta-analysis on the effect of obesity on recurrence after laparoscopic anti-reflux surgery. The Surgeon, 17 (2), 107–118. doi: http://doi.org/10.1016/j.surge.2018.05.001
  41. Leiman, D. A., Riff, B. P., Morgan, S., Metz, D. C., Falk, G. W., French, B. et. al. (2017). Alginate therapy is effective treatment for GERD symptoms: a systematic review and meta-analysis. Diseases of the Esophagus, 30 (5), 1–9. doi: http://doi.org/10.1093/dote/dow020

Downloads

Published

2020-12-25

How to Cite

Oparin, A., Titkova, A., Stepanchenko, K., Tseluyko, V., Kochuieva, M., & Korzh, O. (2020). Gastroesophageal reflux disease in patients with various comorbidal pathology. ScienceRise: Medical Science, (6 (39), 10–14. https://doi.org/10.15587/2519-4798.2020.220010

Issue

No. 6 (39) (2020)

Section

Medical Science

License

Copyright (c) 2020 Aleksey Oparin, Anna Titkova, Kostiantyn Stepanchenko, Vira Tseluyko, Maryna Kochuieva, Oleksii Korzh

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Our journal abides by the Creative Commons CC BY copyright rights and permissions for open access journals.

Authors, who are published in this journal, agree to the following conditions:

1. The authors reserve the right to authorship of the work and pass the first publication right of this work to the journal under the terms of a Creative Commons CC BY, which allows others to freely distribute the published research with the obligatory reference to the authors of the original work and the first publication of the work in this journal.

 2. The authors have the right to conclude separate supplement agreements that relate to non-exclusive work distribution in the form in which it has been published by the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.