Cell-molecular mechanisms of progression of ophthalmological pathology on the background of influence of environmental factors. Literature review

Authors

DOI:

https://doi.org/10.15587/2519-4798.2021.223486

Keywords:

pathological processes of the organ of vision, matrix metalloproteinases, cytokines, vascular endothelial growth factor, p53 protein, heavy metals

Abstract

Modern scientists are increasingly paying attention to the molecular mechanisms of diseases of the visual organ in conditions of anthropogenic pollution. Environmental pollution is mainly due to atmospheric emissions from the metallurgical, automotive, aviation and petrochemical industries, waste from livestock farms and due to the use of mineral fertilizers and pesticides. Ukraine ranks one of the first in Europe in terms of the amount of industrial dirt per capita.

The aim of this literature review was to analyze the role of extra- and intracellular protein structures and molecular mechanisms of some pathological processes of the visual organ that occur under the influence of anthropogenic stress on the human body.

Material and methods. Scientific publications in foreign and Ukranian journals on relevant topics in the last 5 years, the Internet resources.

Research results and their discussion. The literature review expanded the scientific understanding of the role of reparative enzyme (MGMT), vascular endothelial growth factor, Bcl-2 family proteins, p53 and Ki 67 proteins, matrix metalloproteinases in some ophthalmic pathology. Anthropoecological environmental factors have been shown to cause oxidative stress due to mitochondrial dysfunction and apoptosis, which are a component of a complex pathophysiological process in the most common diseases of the visual analyzer.

Conclusions. The study of molecular mechanisms of occurrence and progression of diseases of the visual organ with the participation of protein factors makes it possible to expand the understanding of the pathogenetic links of their development in order to predict the course of the pathological process, adequate treatment and prevention

Author Biographies

Olga Nedtzvetskaya, Kharkiv Medical Academy of Postgraduate Education

MD, Professor

Department of Ophthalmology

Irina Bagmut, Kharkiv Medical Academy of Postgraduate Education

MD, Professor, Head of Department

Department of Clinical Pathological Physiology, Topographic Anatomy and Operative Surgery

Irina Soboleva , Kharkiv Medical Academy of Postgraduate Education

MD, Professor

Department of Ophthalmology

Irina Pastukh , Kharkiv Medical Academy of Postgraduate Education

PhD, Associate Professor

Department of Ophthalmology

Natalia Goncharova, Kharkiv Medical Academy of Postgraduate Education

PhD, Associate Professor

Department of Ophthalmology

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Published

2021-01-30

How to Cite

Nedtzvetskaya, O., Bagmut, I., Soboleva , I., Pastukh , I., & Goncharova, N. . (2021). Cell-molecular mechanisms of progression of ophthalmological pathology on the background of influence of environmental factors. Literature review. ScienceRise: Medical Science, (1 (40), 29–33. https://doi.org/10.15587/2519-4798.2021.223486

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No. 1 (40) (2021)

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Medical Science

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Copyright (c) 2021 Ольга Владимировна Недзвецкая, Ирина Юрьевна Багмут, Ирина Анатольевна Соболева, Ирина Васильевна Пастух, Наталья Анатольевна Гончарова

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