Comparison of kinetics of radiopharmaceutical (99mTc-MDP) in patients with deforming osteoarthritis and rheumatoid arthritis of the hip joints by osteoscintigraphy

Authors

DOI:

https://doi.org/10.15587/2519-4798.2017.97040

Keywords:

radiopharmaceutical, osteoscintigraphy, deforming osteoarthritis, rheumatoid arthritis, integral perfusion, retention

Abstract

The aim of this work is determination of kinetics of radiopharmaceutical (99mTc-MDP) in the nidi of fixation of injured joint structures in patients with deforming osteoarthritis and rheumatoid arthritis of hip joints.

Material and methods of research. Тhe three-phase osteoscintigraphy (3p-OSG) with technetium-methylene diphosphonate ( 99mTc-MDP)  was carried out according to the standard protocol to 92 patients with deforming osteoarthritis and rheumatoid arthritis of hip joints, among which– 54 women and 38 men, 37 - 75 years old.

Results.  Kinetics of 99mTc-MDP in the nidi of injured hip joints fixation at rheumatoid arthritis is characterized with statistically reliable prevalence of integral perfusion, retention, specific accumulation of indicator at the stages of 3-P OSG comparing with fixation nidi at deforming osteoarthritis that correlates with the differences of destructive-reparative processes in them.  

Conclusions. The increase of intensity of radiopharmaceutical (RP) fixation in pathological nidus at rheumatoid arthritis (RA) as to deforming osteoarthritis (DO) indicated the intensification of arterial blood supply of such nidi as a result of active inflammation, influence of infection agent or increased osteoplastic activity. The integral perfusion in rheumatoid arthritis nidi was essentially more at the expanse of the increase of vascular permeability as a result of infection agents affect, activation of the factors of resorption and synthesis of the mineral components of angiogenesis. RP retention increased in the nidi at rheumatoid arthritis that testified to the high extractive ability of such nidi

Author Biography

Pavlo Korol, Kyiv city clinical hospital No. 12 Pidvysoc'kogo str., 4 a, Kyiv, Ukraine, 01103

PhD, head of laboratory

Laboratory of Radioisotope Diagnosis

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Published

2017-03-31

How to Cite

Korol, P. (2017). Comparison of kinetics of radiopharmaceutical (99mTc-MDP) in patients with deforming osteoarthritis and rheumatoid arthritis of the hip joints by osteoscintigraphy. ScienceRise: Medical Science, (3 (11), 24–27. https://doi.org/10.15587/2519-4798.2017.97040

Issue

No. 3 (11) (2017)

Section

Medical Science

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Copyright (c) 2017 Pavlo Korol

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