Study of technological aspects of manufacture of polymer composite material by centrifugal fiber forming method

Authors

DOI:

https://doi.org/10.15587/2706-5448.2024.310805

Keywords:

hesperidin, solid dispersion system, polymer, centrifugal formation of fibers, polymer composite material

Abstract

The object of the study is the technological aspects of manufacturing the hesperidin polymer composite material by the method of centrifugal fiber formation. This method is considered the basis of a relatively new and cost-effective way of producing solid dispersion systems. Using the centrifugal molding method, it is possible to obtain highly soluble forms of active pharmaceutical ingredients in the form of fibers of various sizes using a wide range of polymeric materials with high speed and low cost due to simple equipment. Due to the innovative design of the centrifugal fiber formation method, it was chosen for the development of solid dispersion systems of the bioflavonoid hesperidin, which has a wide range of different pharmacological properties, but low bioavailability.

Solid dispersed systems of hesperidin by the method of centrifugal fiber formation were produced on the basis of a pharmaceutically acceptable polymeric carrier of polyvinylpyrrolidone and mannitol. For the obtained solid dispersed systems, such basic pharmaco-technological characteristics as loss in mass during drying, bulk volume, bulk volume after shrinkage, bulk density, bulk density after shrinkage, compressibility index, Gaussner coefficient were determined.

Comprehensive tests of the stability of the studied samples of the solid dispersion system of hesperidin were carried out under the conditions of accelerated tests for 6 months. According to the obtained results, it was established that the developed polymer composite material is stable in the studied conditions, and its conditional shelf life is 2 years.

A technological scheme for the production of the hesperidin polymer composite material in the form of solid dispersed systems by the method of centrifugal fiber formation has been developed. In particular, the technological process is described step by step and the critical indicators of quality control of the obtained composite material are determined. The proposed technology can be implemented in modern chemical and pharmaceutical industries. This will contribute to the expansion of the market of highly effective socially oriented medicines.

Supporting Agency

  • Volodymyr Bessarabov was supported by the Ministry of Education and Science of Ukraine [0122U000139].

Author Biographies

Vadym Lisovyi, Kyiv National University of Technologies and Design

Department Industrial Pharmacy

Department of Chemical Technologies and Resource Saving

Volodymyr Bessarabov, Kyiv National University of Technologies and Design

Doctor of Technical Sciences

Department of Industrial Pharmacy

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Study of technological aspects of manufacture of polymer composite material by centrifugal fiber forming method

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Published

2024-08-31

How to Cite

Lisovyi, V., & Bessarabov, V. (2024). Study of technological aspects of manufacture of polymer composite material by centrifugal fiber forming method. Technology Audit and Production Reserves, 4(3(78), 22–27. https://doi.org/10.15587/2706-5448.2024.310805

Issue

Vol. 4 No. 3(78) (2024): Chemical engineering

Section

Chemical and Technological Systems

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Copyright (c) 2024 Vadym Lisovyi, Volodymyr Bessarabov

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