Genotypes of the genes of vegf, tnf-a and tnf-b in patients with bladder cancer in the t1n0m0 stage and their association with the degree of neoplasia of the tumor

Abstract

36 patients with bladder cancer in the T1N0M0 stage were selected in the study Of the 36 patients, there were 20 men and 16 women. The age of men was 57.1±5.0, women 54.2± 5.1 years. Thirty healthy individuals constituted a control group, gender characteristics and age consistent with those of patients with bladder cancer. 36 patients with RSM G1 were diagnosed in 2 patients, G2 in 30 patients, G3 in 4 patients. The ratio of GG / GC / CC GEG / GC / CC gene of VEGF patients to the C-r bladder in the T1 stage was 46.7% / 40.1% / 13.3%, in the group of healthy subjects 43.3% / 46.7% / 10%. The ratio of the genotypes of the GC / GA / AA gene of TNF-a to patients with C-r bladder in the T1 stage is 43.75% / 56.25% / 0% in the group of healthy subjects, 43.3% / 46% / 10%. The ratio of TT / TC / SS genotypes of the TNF-b gene in patients with C-r bladder in the T1 stage is 12.5% †/ 56.2% / 31.25%, respectively, in healthy 13.3% / 50% / 36.7%. Of the 36 patients with Cr with bladder Cr in the T1 stage, 83.3% of patients showed G2 neoplasia, 11.1% found G3 neoplasia and 5.5% G1 in G1 patients. With T1G2 bladder cancer, the GG VEGF genotype was detected in 40 % of patients, GC in 26.7%, TNF-a genotype and GA were detected in 50% of patients, GG at 31.25%, and TNF-b gene genotype 43.7% and CC in 25% of patients.