Correction of thiol status in blood and tissues of kidney of rats in the design of acute pyelonephritis and concomitant diabetes mellitus type II


  • S.A. Borisov Odessa National Medical University, Ukraine
  • F.I. Kostyev Odessa National Medical University, Ukraine
  • A.V. Borisov Odessa National Medical University, Ukraine



acute pyelonephritis, thiol status, oxidative stress, diabetes mellitus, flow, medication correction, detoxification


The conducted research is experimental-clinical, conducted in laboratory rats and is devoted to the determination of the effectiveness of correction of thiol status in blood and tissues of kidney of rats in acute pyelonephritis and concomitant streptozotocin-type diabetes mellitus type II. The use of multi-vector drugs in the modeling of acute pyelonephritis with concomitant type 2 diabetes caused a likely increase in the level of reduced glutathione in the blood and kidneys and decreased oxidized in relation to the group with the traditional medication effect. Recovery of thiol status in blood and kidneys of rats in this pathology due to the use of multi-vector drugs will help to normalize the functional capacity of the kidneys. The pathogenetically important role of concomitant type 2 diabetes mellitus in a significant violation of the thiol status in blood plasma and kidney tissues of animals with acute pyelonephritis was established, which showed a decrease in the level of an important component of the antioxidant and detoxification system - reduced glutathione.


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