Levels of quality of life in patients with muscle invasive bladder cancer after organ-preserving treatment

Автор(и)

DOI:

https://doi.org/10.26641/2307-5279.27.1-2.2023.291340

Ключові слова:

radical cystectomy, partial cystectomy, muscle-invasive bladder cancer, quality of life, chemoradiation therapy

Анотація

The aim of the study was to analyze the quality of life of MIBC patients’ life after RC with orthotopic ileal neobladder, after partial cystectomy (PC) with adjuvant radiotherapy (RT) and after PC with adjuvant chemotherapy (CT). A retrospective analysis of 120 MIBC patients who were treated at the Kyiv city clinical oncological center which is the base of  SI “Institute of urology named after academic O.F. Vozianov” NAMS of Ukraine during the period from 2008 to 2019 was performed. The patients were divided into 3 groups depending on the intervention extent. The 1st one included patients after RC (42), group 2 consisted the patients after PC and adjuvant RT , group 3 consisted the patients after PC and adjuvant CT . The patients' quality of life has been assessed by three questionnaires – EORTC QLQ-C30, EORTC SHQ-C22, ICIQ-UI. The results of the study confirm better quality of life after PC with adjuvant CT, especially with regard to physical condition, patients' adaptation in society (social scale), financial toxicity, gastrointestinal tract functioning (according to symptoms of vomiting, nausea and diarrhea). Our study has confirmed that PC can provide adequate control of MIBC in the individual cases and showed that it offers patients a good chance of long-term bladder preservation providing satisfactory overall postoperative health and quality of life. A critical approach should be taken into consideration when choosing the most appropriate regimen for treatment of MIBC and considering between radical cystectomy or partial cystectomy. However, it is important to inform patients that organ-preserving treatment allows them to achieve a better quality of life, the treatment process may be longer than that after radical cystectomy.

Посилання

Ebbing, J., Heckmann, R. C., Collins, J., W., Mil-ler, K., Erber, B., Friedersdorff, F., Fuller, T. F., Busch, J., Seifert, H. H., Ardelt, P., Wetterauer, C., Hos¬seini, A., Jentzmik, F., & Kempken¬steffen, C. (2018). Oncological outcomes, quality of life out-comes and complications of partial cystectomy for selected cases of muscle-invasive bladder cancer. Scientific Reports. 8, Article number: 8360. https://doi.org/10.1038/s41598-018-26089-x

Halkin, N. H. (2007). Kachestvo zhizni posle tsistektomii s razlichnymi sposobami otvedeniya mochi

[Quality of life after cystectomy with various methods of urinary diversion]. Meditsinskie nauki. Klinicheskaia meditsina. 4, 77-84.

Startsev, V. Yu., Dylenok, I. N., & Dzhemilev, T. R. (2019). Sovremennye vozmozhnosti organosokhraniaiushchego lecheniia bolnykh myshech¬no-invazivnym rakom mochevogo puzyria [Modern possibilities of organ-preserving treatment of patients with muscle-invasive bladder cancer]. Urolohicheskie vedomosti, 1. https://doi.org/10.17816/uroved9129-38

Aaronson, N. K., Ahmedzai, S., Bergman, B., Bullinger, M., Cull, A., Duez, N.J., Filiberti, A., Flechtner, H., Fleishman, S. B., de Haes, J. C. J. M., Kaasa, S., Klee, M., Osoba, D., Razavi, D., Ro¬fe, P. B., Schraub, S., Sneeuw, K., Sullivan, M., & Takeda, F. (1993). The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J. Natl. Cancer Inst. 85, 365-376. https://doi.org/10.1093/jnci/85.5.365

European Organisation for Research and Treatment of Cancer. (2014) Sexual Health Questionnaire (EORTC SHQ-C22).

International consultation on incontinence questionnaire-urinary incontinence short form. (2019).

Bessa, A., Martin, R., Häggström, C., Enting, D., Amery, S., Khan, M. S., Cahill, F., Wylie, H., Broadhead, S., Chatterton, K., Malde, S., Nair, R., Thurairaja, R., Kumar, P., Haire, A., Green, S., Northover, M., Briggs, K., & Van Hemelrijck, M. (2020). Unmet needs in sexual health in bladder cancer patients: a systematic review of the evidence. BMC Urology, 20, Article number: 64. https://doi.org/10.1186/s12894-020-00634-1

Yang, L. S., Shan, B. L., Shan, L. L., Chin, P., Murray, S., Ahmadi, N., & Saxena, A. (2016). A systematic review and meta-analysis of quality of life outcomes after radical cystectomy for bladder cancer. Surg. Oncol. 25, 281-297. https://doi.org/10.1016/j.suronc.2016.05.027

Hamad, J., McCloskey, H., Milowsky, M. Royce, T., & Smith, A. (2020). Bladder preservation in muscle-invasive bladder cancer: a comprehensive review. Int Braz J Urol., 46(2), 169-184. https://doi.org/10.1590/s1677-5538.ibju.2020.99.01

Knoedler, J., & Frank. I. (2015). Organ-sparing surgery in urology: partial cystectomy. Curr. Opin. Urol. 25, 111-115. https://doi.org/10.1097/MOU.0000000000000145

Knoedler, J., Boorjian, S. A., Kim, S. P., Weight, C. J., Thapa, P., Tarrell, R. F., Cheville, J. C., & Frank, I. (2012). Does partial cystectomy compromise oncologic outcomes for patients with bladder cancer compared to radical cystectomy? A matched case-control analysis. J Urol. Oct., 188(4), 1115-9. https://doi.org/10.1016/j.juro.2012.06.029

Holzbeitrlein, J. M., Lopez-Corona, E., Boch-ner, B. H., Herr, H. W., Donat, S. M., Russo, P., Dalbagni, G., & Sogani, P. C. (2004). Partial cystectomy: a contemporary review of the Memorial Sloan-Kettering Cancer Center experience and recommendations for patient selection. J. Urol., 172, 878-881. https://doi.org/10.1097/01.ju.0000135530.59860.7d

Kassouf, W., Swanson, D., Kamat, A., Leibovici, D., Siefker-Radtke, A., Munsell, M. F., Grossman, H. B., & Dinney, C. P. N. (2006). Partial cystectomy for muscle invasive urothelial carcinoma of the bladder: a contemporary review of the M. D. Anderson Cancer Center experience. J. Urol. 175, 2058-2062. https://doi.org/10.1016/S0022-5347(06)00322-3

Capitanio, U., Isbarn, H., Shariat, S., Jeldres, C., Zini, L., Saad, F., Graefen, M., Montorsi, F., Perrotte, P., & Karakiewicz, P. I. (2009). Partial cystectomy does not undermine cancer control in appropriately selected patients with urothelial carcinoma of the bladder: a population-based matched analysis. Urology, 74, 858-864. https://doi.org/10.1016/j.urology.2009.03.052

Knoedler, J., & Frank, I. (2015). Organ-sparing surgery in urology: partial cystectomy. Curr. Opin. Urol. 25, 111-115. https://doi.org/10.1097/MOU.0000000000000145

Sveklina, T. A., & Krupin, V. N. (2012). Quality of life in patients with muscle-invasive bladder cancer stages T2B AND T3A after surgical treatment. Cancer Urology, 8(3). 55-59.

##submission.downloads##

Опубліковано

2023-06-30

Номер

Том 27 № 1-2 (2023)

Розділ

Онкоурологія

Ліцензія

Стаття повинна мати візу керівника та офіційне направлення від установи, з якої виходить стаття (з круглою печаткою), і вказівкою, чи є стаття дисертаційною, а також у довільній формі на окремому аркуші - відомості про авторів (прізвище, ім’я, по батькові, посада, вчений ступінь, місце роботи, адреса, контактні телефони, E-mail).

Стаття повина бути підписана всіма авторами, які укладають з редакцією договір пропередачу авторських прав (заповнюється на кожного автора окремо з оригінальним підписом). За таких умов редакція має право на її публікацію та розміщення на сайті видавництва.