Changing of dynamic response of the active muscle soleus in conditions of its ischemization in alcoholic rats when C60 fullerene is administered

Authors

  • Vladislav Bilobrov Taras Shevchenko National University of Kyiv Volodymyrska str., 60, Kyiv, Ukraine, 01033, Ukraine
  • Darya Vulitskaya Taras Shevchenko National University of Kyiv Volodymyrska str., 60, Kyiv, Ukraine, 01033, Ukraine
  • Alexander Nozzdenko Bogomolets National Medical University Tarasa Shevchenka blvd., 13, Kyiv, Ukraine, 01601, Ukraine
  • Svetlana Zay Lesya Ukrainka Eastern European National University Voli ave., 13, Lutsk, Ukraine, 43025, Ukraine
  • Alexander Motuzyuk Lesya Ukrainka Eastern European National University Voli ave., 13, Lutsk, Ukraine, 43025, Ukraine

DOI:

https://doi.org/10.15587/2519-8025.2017.113599

Keywords:

fullerenes, ischemia, muscles, nanostructures, contractions, prophylaxis correction, radical, alcoholization, muscle soleus

Abstract

There were studied the effects of bio-compatible nanostructures С60 on mechanisms of muscle soleus contractions in alcoholized rats at their ischemic lesion for estimating the therapeutic effect of fullerene С60 on the time development of general pathogenesis in the ischemically injured muscular system.

The obtained data testify to the expressed protective effect of С60FAS on the dynamics of muscle soleus contractions in alcocholized rats at their ischemic lesion. It indicates the fact that С60FAS may be considered as promising medical means for prophylaxis and correction of the ischemically injured muscle.

The studies demonstrated that administration of С60FAS causes different therapeutic effects on different zones of the contraction process.   It was demonstrated, that the use of the water solution of fullerenes in dose 1 mg/kg as a protector on dynamic characteristics of skeletal muscles is effective at initial stages of lesions that is at ischemia during 1 hour. At increasing the ischemia duration, the protective influence of the solution decreases that may be connected with irreversible lesions in skeletal muscles, caused by the synergetic effect of two pathologies

Author Biographies

Vladislav Bilobrov, Taras Shevchenko National University of Kyiv Volodymyrska str., 60, Kyiv, Ukraine, 01033

Educational and Scientific Centre "Institute of Biology "

Darya Vulitskaya, Taras Shevchenko National University of Kyiv Volodymyrska str., 60, Kyiv, Ukraine, 01033

Educational and Scientific Centre "Institute of Biology "

Svetlana Zay, Lesya Ukrainka Eastern European National University Voli ave., 13, Lutsk, Ukraine, 43025

Postgraduate student

Department of Human and Animal Physiology

Alexander Motuzyuk, Lesya Ukrainka Eastern European National University Voli ave., 13, Lutsk, Ukraine, 43025

PhD

Department of Human and Animal Physiology

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Published

2017-10-31

How to Cite

Bilobrov, V., Vulitskaya, D., Nozzdenko, A., Zay, S., & Motuzyuk, A. (2017). Changing of dynamic response of the active muscle soleus in conditions of its ischemization in alcoholic rats when C60 fullerene is administered. ScienceRise: Biological Science, (5 (8), 27–32. https://doi.org/10.15587/2519-8025.2017.113599

Issue

No. 5 (8) (2017)

Section

Biological Sciences

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Copyright (c) 2017 Vladislav Bilobrov, Darya Vulitskaya, Alexander Nozzdenko, Svetlana Zay, Alexander Motuzyuk

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