Determination of biochemical indicators of the functional state of livers of white rats for one-time internal intra-abdominal administration of the mixture of nanoparticles of metals (Ag, Cu, Fe, MnО2)

Authors

  • Marina Roman'ko National Scientific Center “Institute of Experimental and Clinical Veterinary Medicine” (NSC "IECVM") Pushkinska str., 83, Kharkiv, Ukraine, 61083, Ukraine https://orcid.org/0000-0003-0285-5603

DOI:

https://doi.org/10.15587/2519-8025.2017.119811

Keywords:

nanoparticles of metals, rats, toxicity, bio-compatibility, liver, peroxide oxidation of lipids, oxidative modification of proteins, enzymes

Abstract

There was established the hepatotoxic effect of the mixture of colloid dispersions of nanoparticles of metals (mixture NPMe: Ag, Cu, Fe, MnО2) compared with the mixture of salts of correspondent metals at the one-time intra-abdominal administration to white rats that has the expressed dose-depending effect. Mechanisms of the hepatotoxic effect of NPMe mixture is doses 1,0, 2,0 and 4,0 mg/kg of a body mass are in formation of the oxidation stress in an animal organism that is accompanied by the increase of enzyme activity of indicative AsAt and HGT and catalase, inhibition of AlAT, AP and general AOA (р≤0,05). The intensification of urea formation along with the increase of the glucose level (р≤0,05) in plasma of rats that received NPMe in increased doses indicates the evident intensification of processes of elimination of nanoparticles that is in the direct proportion to the time of admission and energetic supply of animals.

At the absence of prooxidant effect and regulation of indicators of AOS in rats’ organisms it was proved, that NPMe mixture in dose 0,3 mg/kg of a body mass is biocompatible and has the adaptogenic effect compared with salts of correspondent metals that colloid dispersions of nanoparticles of essential metals can be considered as a prospective substance of drugs and components of fodder additives

Author Biography

Marina Roman'ko, National Scientific Center “Institute of Experimental and Clinical Veterinary Medicine” (NSC "IECVM") Pushkinska str., 83, Kharkiv, Ukraine, 61083

PhD

Department of toxicology, safety and quality of agricultural products NSC "IECVM"

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Published

2017-12-31

How to Cite

Roman’ko, M. (2017). Determination of biochemical indicators of the functional state of livers of white rats for one-time internal intra-abdominal administration of the mixture of nanoparticles of metals (Ag, Cu, Fe, MnО2). ScienceRise: Biological Science, (6 (9), 14–22. https://doi.org/10.15587/2519-8025.2017.119811

Issue

No. 6 (9) (2017)

Section

Biological Sciences

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Copyright (c) 2017 Marina Roman'ko

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