Overview of concepts of the sphingolipid metabolism

Authors

DOI:

https://doi.org/10.15587/2519-8025.2021.234699

Keywords:

sphingolipids, ceramides, mitochondria, apoptosis, insulin resistance, viruses

Abstract

Sphingolipids are important components of the cell involved in the processes of apoptosis, inflammation, oncogenesis, aging, proliferation, differentiation and growth of cells, as well as in the stress-induced response of cells.

The aim. To study research literature for summarizing the new concepts of sphingolipids biochemical role in the development of various pathological conditions.

Materials and methods. The open sources of scientific literature were analyzed.

Results and discussion. According to the analyzed data, the occurrence of pathologies is associated with the sphingolipid imbalance in cells, and excessive accumulation of ceramides, while by preventing the accumulation of ceramides in cells, it is possible to prevent the appearance of cardiac, neurological and metabolic pathologies, including insulin resistance, heart disease (atherosclerosis, heart failure), as well as hepatic steatosis. Therefore, it is promising to search for drugs that can inhibit individual components of the metabolism of sphingolipids and prevent the development of pathology.

Conclusions. Sphingolipids are involved in numerous processes in cells, and changes in the balance of individual members of this class of lipids can play a crucial role in the development of pathological conditions. At the same time, the accumulated data on disorders of the sphingolipid metabolism in various diseases contribute to the development of drugs based on inhibition of the corresponding components of the metabolism of these lipids.

Author Biographies

Galyna Storozhenko, National University of Pharmacy

PhD, Assistant

Department of Biological Chemistry

Vitalina Kharchenko, V. N. Karazin Kharkiv National University

PhD, Associate Professor

Department of Biochemistry

Oksana Krasilnikova, National University of Pharmacy

PhD, Associate Professor

Department of Biological Chemistry

Oksana Tkachenko, National University of Pharmacy

Кандидатка фармацевтичних наук, асистентка

Кафедра біологічної хімії

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Published

2021-06-30

How to Cite

Storozhenko, G., Kharchenko, V., Krasilnikova, O., & Tkachenko, O. (2021). Overview of concepts of the sphingolipid metabolism . ScienceRise: Biological Science, (2(27), 23–27. https://doi.org/10.15587/2519-8025.2021.234699

Issue

No. 2(27) (2021)

Section

Biological research

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Copyright (c) 2021 Galyna Storozhenko, Vitalina Kharchenko, Oksana Krasilnikova, Oksana Tkachenko

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