Chromosomal abnormalities in blood lymphocytes of primary cancer patients in post-chernobyl period

Authors

  • Эмилия Анатольевна Дёмина R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of National Academy of Ukraine Vasylkyvska str., 45, Kyiv, Ukraine, 03022, Ukraine https://orcid.org/0000-0002-1058-0489

DOI:

https://doi.org/10.15587/2519-8025.2016.72316

Keywords:

radiation, precancerous pathology, breast cancer, Hodgkin lymphoma, lymphocytes of blood, aberrations of chromosome

Abstract

This study conducted a cytogenetic examination of cancer patients prior to anti-tumor therapy in order to prevent malignant transformation of precancerous pathologies. In contrast to the control of healthy patients, a higher level of chromosomal exchanges (1.2 / 100 metaphases) has been registered in patients with breast cancer. It was found that the patients with Hodgkin lymphoma have elevated levels of chromosome aberrations by exchanges (4/100 metaphases), which are radiation markers

Author Biography

Эмилия Анатольевна Дёмина, R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of National Academy of Ukraine Vasylkyvska str., 45, Kyiv, Ukraine, 03022

Doctor of biology Science, deputy chief

Department of biological effects of ionizing and non-ionizing irradiations

References

  1. Baloga, V. I. (Ed.) (2011). Dvadcjat' p’jat' rokiv Chornobyl's'koi' katastrofy: Bezpeka majbutn'ogo. Nacional'na dopovid' Ukrai'ny. Kyiv: KiM, 356.
  2. Jablokov, A. V., Nesterenko, V. B., Nesterenko, A. V., Preobrazhenskaja, N. E. (2016). Chernobyl': posledstvija Katastrofy dlja cheloveka i prirody. Moscow: Tov-vo nauchnyh znanij KMK, 826.
  3. Bonchuk, Ju. V., Berkovs'kyj, V. B., Ratya, G. G. (2016). Zona osoblyvoi' radiacijnoi' nebezpeky ChAES: radiacijno-gigijenichne obgruntuvannja isnujuchyh rozmiriv, suchasnyj stan ta perspektyvy. Radiologichni ta medychni naslidky Chornobyl's'koi' katastrofy – trydcjat' rokiv potomu. Kyiv, 185.
  4. D'omina, E. A., Druzhyna, M. O., Rjabchenko, N. M. (2006). Indyvidual'na radiochutlyvist' ljudyny. Kyiv: Logos, 126.
  5. Shalimov, S. A., Grinevich, Ju. A., Mjasoedov, D. V. (Eds.) (2008). Spravochnik po onkologii. Kyiv: Zdorov’ja, 576.
  6. Grinevich, Ju. A., Jugrinova, L. G. (2015). Markery opuholevogo rosta. Kyiv: «Zdorov’ja», 200.
  7. Makkonki, Je. (2008). Genom cheloveka. Moscow: Tehnosfera, 288.
  8. Sompajrak, L. (2006). Chto takoe rak? Moscow: Tehnosfera, 232.
  9. Rassi, H., Haushmand, М., Gorovenko, N. G. (2006). Practical aspects in breast cancer tumors for mutation detection. 17th International Congress on Anti_Cancer Treatment. Paris: ESMO, 184.
  10. Prysjazhnjuk, A. Je. et. al (2016). Rezul'taty 30-richnyh doslidzhen' onkologichnyh naslidkiv Chornobyl's'koi' katastrofy v Ukrai'ni u ramkah nacional'nih ta mizhnarodnyh proektiv. Radioloigichni ta medychni naslidky Chornobyl's'koi' katastrofy – trydcjat' rokiv potomu. Kyiv, 264.
  11. Prysyazhnyuk, A. Ye., Grishchenko, V. G., Fedorenko, Z. P. et. al (2007). Solid cancer incidence in various group of the population affected by the Chernobyl accident. The Health Effects Chernobyl accident. The Health Effects of the Human Victims of the Chernobyl Catastrophe. Amsterdam, Green0pese Int., 127–134.
  12. Boice, J. D., Rosenstein, M., Trout, E. D. (1978). Estimation of Breast Doses and Breast Cancer Risk Associated with Repeated Fluoroscopic Chest Examinations of Women with Tuberculosis. Radiation Research, 73 (2), 373. doi: 10.2307/3574828
  13. Baverstock, K. F., Papworth, D., Vennart, J. (1981). Risks of radiation at low dose rates. The Lancet, 317 (8217), 430–433. doi: 10.1016/s0140-6736(81)91804-3
  14. Baverstock, K. F., Vennart, L. (1983). A note on radium body content and breast cancer in UK. Radium luminescence. Health. Physics, 44, 575–577.
  15. Stavickij, R. V., Blinov, M. M., Rabkin, I. H., Lebedev, L. A. (1994). Radiacionnaja zashhita v medicinskoj radiologii. Moscow: Kabur, 272.
  16. Shevchenko, V. A., Akaeva, Je. A., Eliseev, I. M. et. al (1990). Ispol'zovanie metoda biologicheskoj dozimetrii v uslovijah avarii na ChAJeS. Problemy bezopasnosti v chrezvychajnyh situacijah, 12, 69–90.
  17. Demin, V. T., Demina, Je. A. (2002). Citogeneticheskaja indikacija luchevogo vozdejstvija na tkani molochnoj zhelezy pri provedenii skriningovyh rentgenologicheskih obsledovanij zhenshhin. Zlojakіsnі novoutvorennja, 2, 43–44.
  18. Djomina, Je. A. (2016). Radiogennyj rak: jepidemiologija i pervichnaja profilaktika. Kyiv: Naukova dumka, 196.
  19. Djomina, Je. A. (2015). Luchevaja diagnostika i kancerogennyj risk (vzgljad radiobiologa). Promeneva dіagnostika, promeneva terapіja, 1, 72–77.
  20. Djomina, E. A., Barilyak, I. R. (2010). Medical and genetic consequences of radiation catastrophes (Review). Cytology and Genetics, 44 (3), 186–193. doi: 10.3103/s0095452710030102
  21. Hagmar, L. (2004). Impact of Types of Lymphocyte Chromosomal Aberrations on Human Cancer Risk: Results from Nordic and Italian Cohorts. Cancer Research, 64 (6), 2258–2263. doi: 10.1158/0008-5472.can-03-3360
  22. Monahov, A. S. (2001). Rannee vyjavlenie opuholevyh zabolevanij po citogeneticheskim kriterіjam, opredeljaemym v limfocitah perifericheskoj krovi. Voprosy onkologii, 47 (4), 401–407.
  23. Cytogenetic Dosimetry: Applications in Preparedness for and Response to Radiation Emergencies (2011). International Atomic Energy Agency Vienna, 232.
  24. Mitlman, F. (Ed.) (1995). International System of Cytogenetic Nomenclature for Acquired Chromosome Aberrations. Basel, 120.
  25. Chehun, V. F., Gluzman, D. F. (Eds.) (2016). Ionizirujushhaja radiacija i onkogematologicheskie zabolevanija. Kiev: «DIA», 282.
  26. Kindzel'skij, L. P., Usatenko, V. D., Gubareva, A. A. (1990). Semejnye sluchai limfogranulematoza. Jeksper. Onkologija, 12 (1), 61–63.
  27. Grinevich, Ju. A., Djomina, Je. A.; Jarilin, A. A. (Ed.) (2006). Immunnye i citogeneticheskie jeffekty plotno- i redkoionizirujushhih izluchenij. Kyiv: «Zdorov’ja», 200.

Published

2016-07-01

How to Cite

Дёмина, Э. А. (2016). Chromosomal abnormalities in blood lymphocytes of primary cancer patients in post-chernobyl period. ScienceRise: Biological Science, (1 (1), 20–25. https://doi.org/10.15587/2519-8025.2016.72316

Issue

Section

Biological Sciences