State of glutathione antioxidant system in the rat's tissues of liver, spleen and brain in conditions of malignant growth and injection of experimental drug

Authors

  • Яна Борисівна Раєцька ESC “Institute of Biology and Medicine” Glushkov ave., 2/12, Kyiv, Ukraine, 03127, Ukraine
  • Егор Дмитрович Маринин ESC “Institute of Biology and Medicine” Glushkov ave., 2/12, Kyiv, Ukraine, 03127, Ukraine
  • Олексій Миколайович Савчук ESC “Institute of Biology and Medicine” Glushkov ave., 2/12, Kyiv, Ukraine, 03127, Ukraine

DOI:

https://doi.org/10.15587/2519-8025.2016.82052

Keywords:

malignant growth, glutathione reductase, glutathione peroxidase, reduced glutathione (GSH)

Abstract

The dynamics of average volumes of Guerin's carcinoma for rats was shown with the comparative use of two doses of experimental drug "GREEN". Experimentally most effective dose was 68 mg/kg. The pathological violations of glutathione antioxidant system in the conditions of malignant growth for the injection of drug "GREEN" were determined. The normalization of investigated factors was observed in the rat's tissues of liver, spleen and brain

Author Biographies

Яна Борисівна Раєцька, ESC “Institute of Biology and Medicine” Glushkov ave., 2/12, Kyiv, Ukraine, 03127

PhD

Department of Biochemistry

Егор Дмитрович Маринин, ESC “Institute of Biology and Medicine” Glushkov ave., 2/12, Kyiv, Ukraine, 03127

Department of Biochemistry

Олексій Миколайович Савчук, ESC “Institute of Biology and Medicine” Glushkov ave., 2/12, Kyiv, Ukraine, 03127

Doctor of Biology Sciences

Department of Biochemistry

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Published

2016-11-03

How to Cite

Раєцька, Я. Б., Маринин, Е. Д., & Савчук, О. М. (2016). State of glutathione antioxidant system in the rat’s tissues of liver, spleen and brain in conditions of malignant growth and injection of experimental drug. ScienceRise: Biological Science, (2 (2), 55–60. https://doi.org/10.15587/2519-8025.2016.82052

Issue

No. 2 (2) (2016)

Section

Biological Sciences

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Copyright (c) 2016 Яна Борисівна Раєцька, Егор Дмитрович Маринин, Олексій Миколайович Савчук

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