Prevalence and correlative-statistical interrelation of the dysfunction of the intestinal mucosal barrier in children with symptoms of the food hypersensitivity

Authors

  • Olga Pakholchuk Zaporizhia state medical university Mayakovskogo ave., 26, Zaporizhia, Ukraine, 69035 Municipal institution “Zaporizhia city multiefield children hospital No. 5” Novgorodska str., 28a, Zaporizhia, Ukraine, 69076, Ukraine

DOI:

https://doi.org/10.15587/2519-4798.2018.139736

Keywords:

food intolerance, children, permeability, mucosal barrier, intestinal barrier dysfunction, urine lactulose

Abstract

Food intolerance (FI) in children is one of the most common manifestations of allergy in early childhood, which is confirmed by the results of many epidemiological studies. Studies have shown that the degree of permeability of the intestinal wall is an important link not only in the pathogenesis of FI, but also in the formation of processes of immune tolerance and maturation of immunity.

The aim of the study was to research the prevalence and correlation-statistical relationships of dysfunction of the intestinal barrier in children with symptoms of FI on the skin.

Materials and methods. The primary medical documentation of 154 patients (boys - 76 (49.4%), girls - 78 (50.6%)) with symptoms of food allergy on the skin, age 27.56 [12.98; 56.08] months.

Results. The number of patients with a positive urine test result for permeability of the intestinal barrier for lactulose was 64.3% (n = 99). Every two children out of three (76.5%, n = 26) with symptoms of FI on the skin before the age of 1 year had signs of increased intercellular transport in the intestinal epithelium, which was manifested by the absorption of lactulose. The normal function of the intestinal barrier had less than half of patients under 3 years old. Out of them, 26.3% (n = 26) are children under the age of 1 year, 48.48% are from 1 year to 3 years old. The permeability of the intestine for the lactulose molecule tended to increase in boys (55.6% vs. 44.4%, χ2 = 2.67, p = 0.10) in early childhood. Among schoolchildren, on the contrary, girls prevailed 57.1% against 42.9% (χ2 = 0.29, р = 0.59). Correlation analysis revealed a reliable relationship between the presence of skin barrier permeability and the age of patients and the age of debut of FI symptoms on the skin (r = -0.25, p <0.05 and r = -0.25, p <0.05), but the lactulose level was not associated with sex and duration of the disease. The level of lactulose was not significantly different in children of different age groups (χ2 = 5.83, df = 4, p = 0.21).

Conclusions. Increased intestinal permeability was detected in 64.3% of children with symptoms of FI on the skin, 74% of these patients belong to the age group up to 4 years. The level of lactulose in the urine is not associated with sex, duration of the disease. The feedback of weak connection with age of children and the age of debut of symptoms was revealed.

Author Biography

Olga Pakholchuk, Zaporizhia state medical university Mayakovskogo ave., 26, Zaporizhia, Ukraine, 69035 Municipal institution “Zaporizhia city multiefield children hospital No. 5” Novgorodska str., 28a, Zaporizhia, Ukraine, 69076

PhD, Associate Professor

Department of Faculty Pediatrics

References

  1. Nedelskaia, S. N., Bessykalo, T. H., Shumnaia, T. E. (2011). Rasprostranennost y faktory ryska razvytyia allerhycheskykh zabolevanyi sredy detei h. Zaporozhe [Prevalence and risk factors of the allergic diseases in children in Zaporizhia]. Klinicheskaya immunologiya. Allergologiya. Infektologiya, 2, 50–53.
  2. Bischoff, S. C., Barbara, G., Buurman, W., Ockhuizen, T., Schulzke, J.-D., Serino, M. et. al. (2014). Intestinal permeability – a new target for disease prevention and therapy. BMC Gastroenterology, 14 (1), 189. doi: http://doi.org/10.1186/s12876-014-0189-7
  3. Karaeren, Z., Akbay, A., Demitras, S., Erguder, I., Ozden, A. (2002). A reference interval study of urinary lactulose excretion: a useful test of intestinal permeability in adults. The Turkish Journal of Gastroenterology, 13 (1), 35–39.
  4. Umanets, T. R. (2017). Imunomoduljujuchi efekty probiotykiv [Immunomodelling effects of the probiotics]. Ukrainskyi Medychnyi Chasopys, 2 (118). Available at: https://www.umj.com.ua/article/107205/imunomodulyuyuchi-efekti-probiotikiv
  5. Dongarra, M. L., Rizzello, V., Muccio, L., Fries, W., Cascio, A., Bonaccorsi, I., Ferlazzo, G. (2012). Mucosal Immunology and Probiotics. Current Allergy and Asthma Reports, 13 (1), 19–26. doi: http://doi.org/10.1007/s11882-012-0313-0
  6. Kalach, N., Kapel, N., Waligora-Dupriet, A.-J., Castelain, M.-C., Cousin, M. O., Sauvage, C. et. al. (2013). Intestinal permeability and fecal eosinophil-derived neurotoxin are the best diagnosis tools for digestive non-IgE-mediated cow’s milk allergy in toddlers. Clinical Chemistry and Laboratory Medicine, 51 (2), 351–361. doi: http://doi.org/10.1515/cclm-2012-0083
  7. Johansson, S. G., Bieber, T., Dahl, R., Friedmann, P. S., Lanier, B. Q., Lockey, R. F. et. al. (2004). Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003. Journal of Allergy and Clinical Immunology, 113 (5), 832–836. doi: http://doi.org/10.1016/s0091-6749(04)00930-3
  8. Johansson, S. G. O., Hourihane, J. O., Bousquet, J., Bruijnzeel-Koomen, C., Dreborg, S., Haahtela, T. et. al. (2008). A revised nomenclature for allergy: An EAACI position statement from the EAACI nomenclature task force. Allergy, 56 (9), 813–824. doi: http://doi.org/10.1111/j.1398-9995.2001.00002.x-i1
  9. Chen, T., Liu, X., Ma, L., He, W., Li, W., Cao, Y., Liu, Z. (2014). Food allergens affect the intestinal tight junction permeability in inducing intestinal food allergy in rats. Asian Pacific Journal of Allergy and Immunology, 32 (4), 345–353. doi: http://doi.org/10.12932/ap0443.32.4.2014
  10. Suzuki, T. (2012). Regulation of intestinal epithelial permeability by tight junctions. Cellular and Molecular Life Sciences, 70 (4), 631–659. doi: http://doi.org/10.1007/s00018-012-1070-x
  11. Luss, L. V., Sidorovich, O. I., Uspenskaya, K. S. (2007). Pyshhevaia allerghyia y pyshhevaia neperenosymosti: pryncypi dyaghnostyky i terapii [Food allergy and food intolerance: proncoples of the diagnostics and treatment]. Lechashhyi vrach, 4, 16–20.
  12. Makaevskaia, E. A., Cheremushky, S. V., Kryvoborodova, N. A., Kucheriavii, Yu. A. (2013). Sindrom izbytochnogo bakterial'nogo rosta v tonkoy kishke ot poslednikh nauchnykh dannykh k rutinnoy praktike [Syndrome of the bacterial overgrowth in the small intestine from the recent data to the practice]. Klinicheskie perspektivy ghastroenterologhii, ghepatologhii, 5, 29–40.

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Published

2018-07-27

How to Cite

Pakholchuk, O. (2018). Prevalence and correlative-statistical interrelation of the dysfunction of the intestinal mucosal barrier in children with symptoms of the food hypersensitivity. ScienceRise: Medical Science, (5 (25), 36–39. https://doi.org/10.15587/2519-4798.2018.139736

Issue

No. 5 (25) (2018)

Section

Medical Science

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Copyright (c) 2018 Olga Pakholchuk

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