The course of seizures in patient with supratentorial brain meningiomas (cohort retrospective study)
DOI:
https://doi.org/10.15587/2519-4798.2019.174509Keywords:
Meningioma, epilepsy, neuro-onсology, brain membranes, neurosurgeryAbstract
Meningioma is the most common brain tumour with a favourable prognosis for a long life. Often epileptic seizures are the main clinical manifestation of meningiomas. However, surgical treatment does not always deprive patients of attacks, and vice versa, some attacks after surgery arise for the first time. Investigating the factors that influence the course of epileptic seizures will optimize treatment tactics
Aim: Identify the factors that affect the preservation or emergence of epileptic seizures in patients operated for supratentorial meningiomas of the brain with a view to further personalized correction of anticonvulsants therapies.
Materials and methods: A retrospective analysis of the course of the disease was performed in 242 patients with totally removed supratentorial meningioma of the brain. The remote results of the disease in 176 people were evaluated. The average duration of observation was 37.0 months (12-111).
Results: In 55 (75.3±5.0%) out of 73 patients who had a seizures before surgical treatment, they disappeared in the distant period. Of the 103 patients without trial before surgery, they subsequently arose in 9 people (8,7±2,8%). Seizures were preserved in 8 (32.0±9.5%) out of 25 men and 10 (20.8±5.9%) out of 48 women.
In 6 (50.0±15.1%) of 12 patients with localization of meningiomas in the left parietal lobe epileptic seizures were preserved, this localization was significantly more frequent in the group of patients with persistent seizures after surgery, p <0.05.
The average duration of the disease before surgery is significantly higher in patients who did not seizure free after intervention - 41.3 and 14.3 months respectively. Among those who had a history of seizures less than year, 40 (90.9±4.3%) of 44 patients were seizure free, and in those who were ill more than a year in 13 (56.5±10.6%) out of 23 cases. Among patients who had more than 10 attacks before intervention, after surgery they returned in 60.0±13.1% of cases, whereas among patients with less than 10 seizures before surgery, recidivism was only in 15.5±4.3% of patients. In the group of patients with persistent seizures after surgery, patients with more than 10 seizures in history were significantly more likely to suffer, p<0.01.
Conclusions: Total removal of meningiomas can make about ¾ patients seizure free. Localization of the tumour in the left parietal region is associated with a greater likelihood of preservation of epilepsy after surgery. The longer patient has the illness and the more seizures he has, the greater the probability of convulsions after surgical treatment
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Copyright (c) 2019 Taras Studeniak, Volodymyr Smolanka, Volodymyr Smolanka, Volodymyr Smolanka, Andriy Smolanka, Andriy Smolanka, Andriy Smolanka
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