Features of kidney damage in patients with newly diagnosed diabetes mellitus type 2 and abdominal obesity
DOI:
https://doi.org/10.26641/2307-5279.21.4.2017.149784Keywords:
diabetes mellitus, chronic kidney disease, glomerular filtration rate, renal functional status, abdominal obesity, arterial hypertension, glomerular hyperfiltration, albuminuria, microglobulinuriaAbstract
The article presents the results of assessing the main kidney markers in patients with newly diagnosed type 2 diabetes mellitus (DM) and abdominal obesity. 20 patients (group 1) with first-established diabetes mellitus type 2, abdominal obesity I–III degree and arterial hypertension (AH) stage I–II, 1 degree, high risk, were examined. The average age was 47,0 (42,0, 52,0) years, among the patients of men – 8 (40,0%) patients, women – 12 (60,0%). The mean BMI was 35.7 (32,4; 40,6) kg/m2. The 2 (control) group included 12 practically healthy people: the median age was 29,0 (24,0, 33,5) years, among them men – 6 (50.0%), women – 6 (50,0%), median BMI was 22,3 (21,0, 23,0) kg/m2. In the group of people with newly diagnosed type 2 diabetes and abdominal obesity increased anthropometric parameters, which characterize metabolic changes (waist circumference, BMI, body surface area) were identified. Statistical analysis showed that patients with newly diagnosed type 2 diabetes had the following changes in renal function: albuminuria (in 70,0% of cases), b2-microglobulinuria (in 90,0% of individuals), increased urine albumin / creatinine ratio and b2-microglobulin urine / creatinine urine ratio (in 50,0% and 90,0% of cases, respectively); and hyperfiltration (in half of patients). Thus, in the group of people with newly diagnosed type 2 diabetes, both components of renal dysfunction are involved, as evidenced by changes in the main markers of the functional state of the kidneys, which is the result of pronounced, clinically manifested insulin resistance. These facts demonstrate the need for early diagnosis, both diabetes mellitus and kidney damage, as well as timely treatment of the underlying disease and its complications.References
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