Investigation of the neuroprotective effect of halloysite nanocrystals on the restorative function of mice brain neurons

Authors

DOI:

https://doi.org/10.15587/2519-8025.2017.113525

Keywords:

neuroptotective, nanocrystals, halloysite, antioxidant, nanotubes, amyloid genesis

Abstract

There were studied neuroprotective effects of halloysite nanocrystals on the decrease of protein synthesis – amyloid proteins and activation of neurogenesis in mice with genetic mutation of АРР, PSN -1, PSN – 2 genes. Halloysite inhibits B monoaminoxidase activity, at that A monoaminoxidase activity increases. All studied compounds inhibit Са2+ glutamate-induced hold in synaptosomes. The study was realized on mice of С57BL/6 line with the preliminary reproduction of the defect of beta-amyloid proteins. Nanotubular halloysite was used as a neuroprotector. The analysis of the change of the quantity and localization of aggregates of beta-amyloid proteins before and after using nanotubular halloysite was realized by methods of fluorescent detecting of сonfocal microscopy. There is demonstrated the neuroprotective interaction and stimulation of neurons restoration. The results demonstrated the decrease of beta-amyloid proteins, neurogenesis activation, high antioxidant potential of halloysite nanocrystals that is a precondition of the neuroprotective potential of nanotubular halloysite

Author Biography

Semen Buriachenko, NSC Institute of Experimental and Clinical Veterinary Medicine Pushkinska str., 83, Kharkiv, Ukraine, 61023

Postgraduate StudentDepartment of Viral Bird Diseases

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Published

2017-10-31

How to Cite

Buriachenko, S. (2017). Investigation of the neuroprotective effect of halloysite nanocrystals on the restorative function of mice brain neurons. ScienceRise: Biological Science, (5 (8), 12–17. https://doi.org/10.15587/2519-8025.2017.113525

Issue

No. 5 (8) (2017)

Section

Biological Sciences

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Copyright (c) 2017 Semen Buriachenko

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