Fibrinogen and prothrombin blood content under ischemic stroke complicated by type 2 diabetes mellitus

Authors

  • Olha Kravchenko Kyiv National Taras Shevchenko University Akademika Glushkova ave., 2, Kyiv, Ukraine, 03022, Ukraine
  • Maria Tymoshenko Kyiv National Taras Shevchenko University Akademika Glushkova ave., 2, Kyiv, Ukraine, 03022, Ukraine
  • Tetyana Tsarenko Kyiv National Taras Shevchenko University Akademika Glushkova ave., 2, Kyiv, Ukraine, 03022, Ukraine

DOI:

https://doi.org/10.15587/2519-8025.2017.119831

Keywords:

ischemic stroke, type 2 diabetes mellitus, fibrinogen, prothrombin

Abstract

The article is dedicated to evaluation of general clinical and some hemostatic parameters (fibrinogen, soluble fibrin monomeric complexes and prothrombin content) of patients with ischemic stroke under presence or absence of type2 diabetes mellitus. It has been established that diabetes mellitus patients with ischemic stroke are more likely to have hyperlipidemia, peripheral vascular disease and high body mass index. The conducted research has established the statistically significant changes of fibrinogen and soluble fibrin monomer complexes (SFMC) levels under both investigated pathologies (ischemic stroke and ischemic stroke complicated by insulin-independent diabetes mellitus). SFMC, the early marker of thrombophilia, was significantly higher compared to the reference values in case of stroke as well as stroke with diabetes. It was established that fibrinogen indexes were higher under IS with DM, whereas SFMC had more deviated meanings comparing with the control parameters under ischemic stroke alone. The higher SFMC level in acute phase of stroke independently of diabetes present was a statistically confirmed predictor of mortality.

Nevertheless statistically significant differences of fibrinogen and SFMC levels in patients with ischemic stroke and IS+DMwere not detected and there were no differences of protrombin content neither comparing with the control nor between the studied pathologies. The obtained results have shown that ischemic stroke with and without type 2 diabetes mellitus are characterized by similar changes of the investigated hemostasis parameters

Author Biographies

Olha Kravchenko, Kyiv National Taras Shevchenko University Akademika Glushkova ave., 2, Kyiv, Ukraine, 03022

PhD, associate professor

Department of Biochemistry, NSC "Institute of Biology and Medicine"

Maria Tymoshenko, Kyiv National Taras Shevchenko University Akademika Glushkova ave., 2, Kyiv, Ukraine, 03022

PhD, Junior Researcher

Department of Biochemistry, NSC "Institute of Biology and Medicine"

Tetyana Tsarenko, Kyiv National Taras Shevchenko University Akademika Glushkova ave., 2, Kyiv, Ukraine, 03022

Postgraduate student

Department of Biochemistry, NSC "Institute of Biology and Medicine"

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Published

2017-12-31

How to Cite

Kravchenko, O., Tymoshenko, M., & Tsarenko, T. (2017). Fibrinogen and prothrombin blood content under ischemic stroke complicated by type 2 diabetes mellitus. ScienceRise: Biological Science, (6 (9), 23–26. https://doi.org/10.15587/2519-8025.2017.119831

Issue

No. 6 (9) (2017)

Section

Biological Sciences

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Copyright (c) 2017 Olha Kravchenko, Maria Tymoshenko, Tetyana Tsarenko

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