Pathogenesis and methods of diagnosis of chronic kidney disease in cats: retrospective analysis (1981–2007)

Authors

DOI:

https://doi.org/10.15587/2519-8025.2021.249714

Keywords:

chronic kidney disease, age, cats, pathogenesis, diagnosis, azotemia, endogenous intoxication

Abstract

The aim: to conduct a retrospective analysis of literature sources on the pathogenesis and methods of diagnosis of chronic kidney disease in cats.

Materials and methods. The research was conducted by the method of scientific literature open-source analysis: PubMed, Elsevier, electronic resources of the National Library named after V.I. Vernadsky (1981–2007).

Results. Chronic kidney disease is a common reason for cat owners to go to veterinary clinics. The term “chronic kidney disease” has a broader meaning than the more limited and not very specific name – chronic renal failure; it is also used to indicate the preazotemic stage of the disease. Chronic kidney disease is characterized by a gradual deterioration of the clinical condition of animals due to progressive decline in renal function. An idea of the pathogenesis and methods of diagnosis of chronic kidney disease in the period from 1981 to 2007 is presented.

Conclusions. According to the results of retrospective analysis of literature sources for the period from 1981 to 2007, the basis was identified aspects of the pathogenesis of chronic kidney disease in domestic cats, which have not lost relevance today. The main link during chronic kidney disease in cats is the development of hyperazotemia and, as a consequence, endogenous intoxication of the body, which develops gradually and leads to the death of the animal. The morphological basis of chronic kidney disease in cats is the development of diffuse nephrosclerosis, which is reflected in the results of clinical, biochemical and instrumental studies. According to biochemical analysis of blood, in cats recorded an increase in urea and creatinine, the results of clinical studies of urine showed a decrease in its relative density, as well as the development of proteinuria, the appearance of erythrocytes and cylinders. According to the results of hematological research, anemic syndrome develops due to decreased erythropoietin synthesis. With age in cats, ultrasound examination of the kidneys reveals a decrease in their volume due to uniform sclerosis of the parenchyma: it is determined by its thinning and increased echogenicity due to the accumulation of connective tissue components, which is a sign of nephrosclerosis. Although kidney biopsy is the most informative method of diagnosing chronic kidney disease, it has many contraindications, which does not allow its use in the routine diagnosis of nephropathy in domestic cats. its thinning and increase in echogenicity due to the accumulation of connective tissue components, which is a sign of nephrosclerosis, is determined. Although kidney biopsy is the most informative method of diagnosing chronic kidney disease, it has many contraindications, which does not allow its use in the routine diagnosis of nephropathy in domestic cats. Its thinning and increase in echogenicity due to the accumulation of connective tissue components, which is a sign of nephrosclerosis, is determined

Author Biographies

Dmytro Morozenko, National University of Pharmacy

Doctor of Veterinary Sciences, Senior Researcher, Head of Department

Department of Veterinary Medicine and Pharmacy

Roman Dotsenko, National University of Pharmacy

PhD, Senior Researcher, Associate Professor

Department of Veterinary Medicine and Pharmacy

Yevheniia Vashchyk, National University of Pharmacy

Doctor of Veterinary Sciences, Associate Professor

Department of Veterinary Medicine and Pharmacy

Andriy Zakhariev, National University of Pharmacy

PhD, Associate Professor

Department of Veterinary Medicine and Pharmacy

Nataliia Seliukova, National University of Pharmacy

Doctor of Biological Sciences, Associate Professor

Department of Veterinary Medicine and Pharmacy

Andrii Zemlianskyi, National University of Pharmacy

PhD, Associate Professor

Department of Veterinary Medicine and Pharmacy

Ekaterina Dotsenko, National scientific center «Institute of Experimental and Clinical Veterinary Medicine»

PhD, Senior Researcher

Laboratory "Veterinary Sanitation and Parasitology"

References

  1. Frensi, T. (2005). Khronicheskoe zabolevanie pochek u koshki. Waltham Focus, 15 (1), 28–31.
  2. Gunn-Moore, D. (2006). Considering older cats. Journal of Small Animal Practice, 47 (8), 430–431. doi: http://doi.org/10.1111/j.1748-5827.2006.00199.x
  3. Braun, S. A. (2005). Novyi podkhod k kontroliu khronicheskogo zabolevaniia pochek. Waltham Focus, 15 (1), 2–5.
  4. Chuvaev, I. V. (Ed.) (2004). Pochechnaia nedostatochnost plotoiadnykh. Veterinarnaia praktika. Moscow, 4 (27), 21–24.
  5. Eliot, Dzh. (2000). Uvelichenie prodolzhitelnosti zhizni koshek s pochechnoi nedostatochnostiu. Waltham Focus, 10 (4), 10–14.
  6. Hostetter, T. H., Olson, J. L., Rennke, H. G., Venkatachalam, M. A., Brenner, B. M. (1981). Hyperfiltration in remnant nephrons: a potentially adverse response to renal ablation. American Journal of Physiology-Renal Physiology, 241 (1), 85–93. doi: http://doi.org/10.1152/ajprenal.1981.241.1.f85
  7. White, J., Norris, J., Baral, R., Malik, R. (2006). Naturally-occurring chronic renal disease in Australian cats: a prospective study of 184 cases. Australian Veterinary Journal, 84 (6), 188–194. doi: http://doi.org/10.1111/j.1751-0813.2006.tb12796.x
  8. Stages of Feline Chronic Renal Disease (2004). Society IRI. Available at: http://www.iris-kidney.com
  9. Khaller, M. (2000). Issledovanie funktsii pochek u sobak i koshek. Waltham Focus, 10 (1), 10–14.
  10. Elliot, D. A. (2005). Organizatsiia kormleniia koshek pri khronicheskom zabolevanii pochek. Waltham Focus, 15 (1), 14–19.
  11. Kirk, R., Bonagura, D. (2005). Sovremennyi kurs veterinarnoi meditsiny Kirka. Moscow: OOO «Akvarium print», 1376.
  12. Brown, S. A., Crowell, W. A., Brown, C. A., Barsanti, J. A., Finco, D. R. (1997). Pathophysiology and management of progressive renaldisease. The Veterinary Journal, 154 (2), 93–109. doi: http://doi.org/10.1016/s1090-0233(97)80048-2
  13. Lipin, A., Sanin, A., Zinchenko, E. (2002). Veterinarnyi spravochnik traditsionnykh i netraditsionnykh metodov lecheniia koshek. Moscow: ZAO Izd-vo Tsentrpoligraf, 649.
  14. Aliaev, Iu. G., Amosov, A. V., Androsova, S. O. et. al. (2000). Nefrologiia. Moscow: Meditsina, 688.
  15. Shulutko, B. I. (1993). Bolezni pecheni i pochek. Saint Petersburg: Izdatelstvo Sankt-Peterburgskogo sanitarno-gigienicheskogo medinstituta, 480.
  16. Scherbakov, G. G., Korobov, A. V., Anokhin, B. M. et. al. (2002). Vnutrennie bolezni zhivotnykh. Saint Petersburg: Izdatelstvo «Lan», 736.
  17. Bakaliuk, O. Y. (2003). Nefrolohiia dlia simeinoho likaria. Ternopil: Ukrmedknyha, 440.
  18. Senior, D. F. (2007). Etiolohiia, patohenez i likuvannia nyrkovoi nedostatnosti u sobak. Veterynarna praktyka, 3, 6–9.
  19. Beloborodova, N. V., Osipov, G. A. (2002). Gomeostaz malykh molekul mikrobnogo proiskhozhdeniia i ego rol vo vzaimootnosheniiakh mikroorganizmov s ego khoziainom. Novosti meditsiny i farmatsii, 3-4, 44–48.
  20. Kyseleva, A. F., Zozuliak, V. Y. (1984). Nefroskleroz. Kyiv: Zdorovia, 152.
  21. Watoson, A. (1998). Urine specific gravity in practice. Australian Veterinary Journal, 76 (6), 392–398. doi: http://doi.org/10.1111/j.1751-0813.1998.tb12384.x
  22. Chandler, E. A., Gaskell, K. Dzh., Gaskell, R. M. (2002). Bolezni koshek. Moscow: Akvarium LTD, 696.
  23. Bainbridzh, D., Eliota, D. (Eds.) (2003). Nefrologiia i urologiia sobak i koshek. Moscow: Akvarium LTD, 272.
  24. Lefebr, G. P., Bron, Zh.-P., Uotson, A. D. (2005). Ranniaia diagnostika khronicheskoi pochechnoi nedostatochnosti u sobak. Waltham Focus, 15 (1), 6–13.
  25. Sasaki, K., Ma, Z., Khatlani, T. S., Okuda, M., Inokuma, H., Onishi, T. (2003). Evaluation of Feline Serum Amyloid A (SAA) as an Inflammatory Marker. Journal of Veterinary Medical Science, 65 (4), 545–548. doi: http://doi.org/10.1292/jvms.65.545
  26. Lees, G. E. (2004). Early diagnosis of renal disease and renal failure. Veterinary Clinics of North America: Small Animal Practice, 34 (4), 867–885. doi: http://doi.org/10.1016/j.cvsm.2004.03.004
  27. Boikiv, D. P., Bondarchuk, T. I., Ivankiv, O. L. et. al. (2007). Biokhimichni pokaznyky v normi i pry patolohii. Kyiv: Medytsyna, 320.
  28. Arata, S., Ohmi, A., Mizukoshi, F., Baba, K., Ohno, K., Setoguchi, A., Tsujimoto, H. (2005). Urinary Transforming Growth Factor-.BETA.1 in Feline Chronic Renal Failure. Journal of Veterinary Medical Science, 67 (12), 1253–1255. doi: http://doi.org/10.1292/jvms.67.1253
  29. Isles, C. G., Paterson, G. R. (1997). Serum creatinine and urea: make the most of these simple tests. British Journal of Hospital Medicine, 55 (8), 513–516.
  30. Muller, F., Dommergues, M., Bussières, L., Lortat-Jacob, S., Loirat, C., Oury, J. F. et. al. (1996). Development of human renal function: reference intervals for 10 biochemical markers in fetal urine. Clinical Chemistry, 42 (11), 1855–1860. doi: http://doi.org/10.1093/clinchem/42.11.1855
  31. Shavyrin, A. A., Bychkova, L. V., Baibulatova, S. R. et. al. (2002). Novoe v issledovanii funktsionalnogo sostoianiia pochek. Vestnik RUDN. Seriia Meditsina, 2, 25–27.
  32. Vovkotrub, N. V. (2005). Nefrotychnyi syndrom u vysokoproduktyvnykh koriv. Bila Tserkva, 22.
  33. Malinin, A. I., Kharchenko, E. D., Tertyshnik, V. I. (1954). O funktsionalnom sostoianii pochek pri eksperimentalnom nefrite u sobak. Sbornik trudov KHZVI. Kyiv: Izd. s-kh. lit-ry, 171–177.
  34. Deguchi, E., Akuzawa, M. (1997). Renal Clearance of Endogenous Creatinine, Urea, Sodium, and Potassium in Normal Cats and Cats with Chronic Renal Failure. Journal of Veterinary Medical Science, 59 (7), 509–512. doi: http://doi.org/10.1292/jvms.59.509
  35. Vakhrushev, Ia. M., Shkatova, E. Iu. (2007). Laboratornye metody diagnostiki. Rostov-na-Donu: Feniks, 96.
  36. Kapitanenko, A. M., Dochkin, I. I. (1988). Klinicheskii analiz laboratornykh issledovanii v praktike voennogo vracha. Moscow: Voenizdat, 270.
  37. Elliott, J., Syme, H. M., Reubens, E., Markwell, P. J. (2003). Assessment of acid‐base status of cats with naturally occurring chronic renal failure. Journal of Small Animal Practice, 44 (2), 65–70. doi: http://doi.org/10.1111/j.1748-5827.2003.tb00122.x
  38. Miyazaki, M., Soeta, S., Yamagishi, N., Taira, H., Suzuki, A., Yamashita, T. (2007). Tubulointerstitial nephritis causes decreased renal expression and urinary excretion of cauxin, a major urinary protein of the domestic cat. Research in Veterinary Science, 82 (1), 76–79. doi: http://doi.org/10.1016/j.rvsc.2006.06.009
  39. Page, Zh.-P. (2006). Znachimost issledovaniia glaznogo dna v diagnostike nefropatii. Veterinar, 1, 10–17.
  40. Preston, R. A., Epstein, M. (1997). Ischemic renal disease: an emerging cause of chronic renal failure and end-stage renal disease. Journal of Hypertension, 15 (12), 1365–1377. doi: http://doi.org/10.1097/00004872-199715120-00001
  41. Teilor, P. M., Khaulton, D. E. (2004). Travmatologiia sobak i koshek. Moscow: Akvarium-print, 224.
  42. Radermacher, J. (2005). Ultrasonography of the kidney and renal vessels. I. Normal findings, inherited and parenchymal diseases. Urologe. A., 44 (11), 1351–1363.
  43. Slesarenko, N. A., Kaidanovskaia, N. A. (2006). Osobennosti stroeniia pochek novorozhdennykh kotiat po dannym ultrazvukovogo i morfosonograficheskogo issledovaniia. Rossiiskii veterinarnyi zhurnal, 2, 22–25.
  44. Chizh, A. S., Pilotovich, V. S., Kolb, V. G. (2004). Nefrologiia i urologiia. Minsk: Knizhnyi dom, 464.
  45. Ivanov, V. V. (2005). Klinicheskoe ultrazvukovoe issledovanie organov briushnoi i grudnoi polosti u sobak i koshek. Moscow: Akvarium-print, 176.
  46. Neutrup, C. H., Tobias, R. (1998). An atlas and textbook of diagnostic ultrasonography of the dog and cat. Copyright, Hannover, 209.
  47. Kaidanovskaia, N. A., Slesarenko, N. A. (2007). Morfosonograficheskie kharakteristiki pochek pri nefroskleroze. Bolezni melkikh domashnikh zhivotnykh. Moskva, 55–56.
  48. Buturović-Ponikvar, J., Višnar-Perovič, A. (2003). Ultrasonography in chronic renal failure. European Journal of Radiology, 46 (2), 115–122. doi: http://doi.org/10.1016/s0720-048x(03)00073-1
  49. Vaden, S. L. (2005). Renal biopsy of dogs and cats. Clinical Techniques in Small Animal Practice, 20 (1), 11–22. doi: http://doi.org/10.1053/j.ctsap.2004.12.003

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Published

2021-12-30

How to Cite

Morozenko, D., Dotsenko, R., Vashchyk, Y., Zakhariev, A., Seliukova, N., Zemlianskyi, A., & Dotsenko, E. (2021). Pathogenesis and methods of diagnosis of chronic kidney disease in cats: retrospective analysis (1981–2007). ScienceRise: Biological Science, (4 (29), 19–24. https://doi.org/10.15587/2519-8025.2021.249714

Issue

No. 4 (29) (2021)

Section

Veterinary research

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Copyright (c) 2021 Dmytro Morozenko, Roman Dotsenko, Yevheniia Vashchyk, Andriy Zakhariev, Nataliia Seliukova, Andrii Zemlianskyi, Ekaterina Dotsenko

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