Effect of zinc and acetate trigonella foenum graecum on the metabolism of nitric oxide in rats with alcohol dependence formed brain

Authors

  • Lesya Sokur Taras Shevchenko National University of Kyiv Volodymyrska str., 64/13, Kyiv, Ukraine, 01601, Ukraine
  • Ielyzaveta Torgalo Taras Shevchenko National University of Kyiv Volodymyrska str., 64/13, Kyiv, Ukraine, 01601, Ukraine

DOI:

https://doi.org/10.15587/2519-8025.2017.83076

Keywords:

alcohol dependence, fenugreek, zinc acetate, metabolism, nitrosothiols, conditions of consumption, brain

Abstract

The influence of zinc acetate and fenugreek (Trigonella foenum) on the metabolism of nitric oxide in the brain of rats with formed alcohol dependence was investigated. To determine the activity of NO-synthase and its' isoforms (cytokine-dependent iNOS and Са2+-dependent cNOS) in brains of rats with formed alcohol addiction. To measure the level of NO2–, NO3– and S-nitrosothioles in brains of rats with formed alcohol addiction. To study the effects of zinc acetate and Fenugreek (Trigonella foenum graecum) on activity of NO-synthase and its' isoforms (cytokine-dependent iNOS and Са2+-dependent cNOS) and level of NO2–, NO3– and S-nitrosothioles in brains of rats with formed alcohol addiction.
It was shown that under conditions of consumption of alcohol the appropriate links of NO cycle were activated: NO-synthase (by means of cytokine-dependent iNOS and Ca2+-dependent NO-synthase isoforms in terms of initial studies: 1-4 weeks) and NO deposition as nitrosothiols

Author Biographies

Lesya Sokur, Taras Shevchenko National University of Kyiv Volodymyrska str., 64/13, Kyiv, Ukraine, 01601

Doctor of Biological Sciences, Senior Researcher

Deputy Director for Science

Educational and Scientific Center "Institute of Biology and Medicine"

Ielyzaveta Torgalo, Taras Shevchenko National University of Kyiv Volodymyrska str., 64/13, Kyiv, Ukraine, 01601

PhD, Research associate

Educational and Scientific Center "InstituteofBiologyand Medicine"

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Published

2017-02-28

How to Cite

Sokur, L., & Torgalo, I. (2017). Effect of zinc and acetate trigonella foenum graecum on the metabolism of nitric oxide in rats with alcohol dependence formed brain. ScienceRise: Biological Science, (1 (4), 4–8. https://doi.org/10.15587/2519-8025.2017.83076

Issue

No. 1 (4) (2017)

Section

Biological Sciences

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Copyright (c) 2016 Єлизавета Олександрівна Tоргало, Леся Вадимівна Сокур

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