Сondition of indicators of antimicrobial resistance in patients with allergic dermatoses complicated by staphylococcal infection, depending on the severity of the diseases

Authors

  • Svetlana Dzhoraeva State Institution «Institute of Dermatology and Venereology of the National Academy of Medical Sciences of Ukraine» Chernyshevska str., 7/9, Kharkiv, Ukraine, 61057, Ukraine https://orcid.org/0000-0003-2486-5474

DOI:

https://doi.org/10.15587/2519-4798.2020.193201

Keywords:

allergic dermatosis, clinical course, antimicrobial resistance

Abstract

The aim of the work: To determine and analyse the results of indicators of antimicrobial immunity in patients with an uncomfortable and aggravated course of allergic dermatoses using auto-serums and auto-strains of Staphylococcus aureus obtained from patients with atopic dermatitis (AD) and true eczema (ТE).

Methods of research: In the study, 107 patients were examined for AD and TE who were hospitalized in the Department of Dermatology of the SЕ “Institute of Dermatology on Venereology of the National Academy of Medical Sciences of Ukraine” in 2016-2019, which included an analysis of complaints and medical history data, an assessment of the severity of the disease according to the SCORAD scale and EASI, conducting general clinical, bacteriological and immunological studies.

Examination of patients was carried out during an exacerbation of the disease.

Results: As a result of the studies, it was found that changes in immunological reactivity in patients with AD were more pronounced than in patients with TE, which was manifested by significant inhibition of almost all indicators of the functional activity of blood leukocytes (both indicators of the phagocytic reaction, and spontaneous and induced HCT test) from moderate to severe, this is especially noticeable in the group of patients with severe course of AD.

It was shown that in patients with AD and TE in the acute stage, the formation of a secondary immunodeficiency state is observed, which is manifested by a decrease in the leukocyte phagocytic activity, which may be an indication for inclusion in the complex treatment of immunocorrective therapy

Author Biography

Svetlana Dzhoraeva, State Institution «Institute of Dermatology and Venereology of the National Academy of Medical Sciences of Ukraine» Chernyshevska str., 7/9, Kharkiv, Ukraine, 61057

PhD, Head of Department

Laboratory and Experimental Department

References

  1. Soloshenko, E. M., Stulii, O. M., Roshcheniuk, L. V., Amer, L. B., Knyzhenko, L. B., Volkova, N. S. ta in. (2014). Zakhvoriuvanist na poshyreni dermatozy za danymy zvertannia v likuvalni zaklady shkirno-venerolohichnoho ta alerholohichnoho profiliu m. Kharkova. Zhurnal dermatovenerolohii ta kosmetolohii im. M. O. Torsuieva, 1-2 (34), 35–40.
  2. Volkoslavskaia, V. N., Roscheniuk, L. V. (2018). Socialnye, ekologicheskie kharakteristiki zabolevaemosti khronicheskimi dermatozami v Ukraine. Dermatologіia ta venerologіia, 3 (81), 59–64.
  3. Drucker, A. M., Wang, A. R., Li, W.-Q., Sevetson, E., Block, J. K., Qureshi, A. A. (2017). The Burden of Atopic Dermatitis: Summary of a Report for the National Eczema Association. Journal of Investigative Dermatology, 137 (1), 26–30. doi: http://doi.org/10.1016/j.jid.2016.07.012
  4. Macharadze, D. SH. (2005). Tiazheloe upornoe techenie atopicheskogo dermatita: osobennosti lecheniia u detei. Lechaschii vrach, 9, 74–78.
  5. Chiesa Fuxench, Z. C., Block, J. K., Boguniewicz, M., Boyle, J., Fonacier, L., Gelfand, J. M. et. al. (2019). Atopic Dermatitis in America Study: A Cross-Sectional Study Examining the Prevalence and Disease Burden of Atopic Dermatitis in the US Adult Population. Journal of Investigative Dermatology, 139 (3), 583–590. doi: http://doi.org/10.1016/j.jid.2018.08.028
  6. Маr, A., Marks, R. (2000). Prevention of atopic dermatitis of atopic dermatitis. Atopic dermatitis: The epidemiology, Causes and Prevention of Atopic Eczema. Cambridge: Cambridge University Press, 205–218. doi: http://doi.org/10.1017/cbo9780511545771.018
  7. Berezneva, N. V., Slabkaia, E. V., Meshkova, R. Ia., Aksenova, S. A. (2010). Sravnenie pokazatelei immunnogo statusa i klinicheskoi effektivnosti v zavisimosti ot vida terapii u pacientov s oslozhnennymi I neoslozhnennymi formami atopicheskogo dermatita. Vestnik Smolenskoi medicinskoi akademii, 4, 85–88.
  8. Paller, A. S., Kong, H. H., Seed, P., Naik, S., Scharschmidt, T. C., Gallo, R. L. et. al. (2019). The microbiome in patients with atopic dermatitis. Journal of Allergy and Clinical Immunology, 143 (1), 26–35. doi: http://doi.org/10.1016/j.jaci.2018.11.015
  9. Reviakina, V. A. (2004). Immunologicheskie osnovy razvitiia atopicheskogo dermatita i novaia strategiia terapii. Сonsilium medicum, 6 (3), 176–180.
  10. Sergeev, Iu. V., Sergeev, A. Iu. (2001). Atopicheskii dermatit. Sovremennye koncepcii immunopatogeneza. Uspekhi klinicheskoi immunologii i allergologii, 2, 287–294.
  11. Ionesku, M. A. (2014). Kozhnii barer: strukturnye i immunnye izmeneniia pri rasprostranennykh bolezniakh kozhi. Rossiiskii allergologicheskii zhurnal, 2, 83–89.
  12. Tamrazova, O. B., Gureeva, M. A., Kuznecova, T. A., Vorobeva, A. S. (2016). Vozrastnaia evoliucionnaia dinamika atopicheskogo dermatita. Pediatriia, 2, 153–159.
  13. Zhiltsova, E. E., Chakhoyan, L. P. (2018). The role of immunological disorders in the development of atopic dermatitis. Research’n Practical Medicine Journal, 5 (1), 45–51. doi: http://doi.org/10.17709/2409-2231-2018-5-1-5
  14. Denysenko O. I. (2010). Alerhodermatozy v yododefitsytnomu rehioni. Chernivtsi: BDMU, 156.
  15. Drannik, G. N. (2010). Klinicheskaia immunologiia i allergologiia. Kyiv: OOO Poligraf plius, 552.
  16. Stepan, N. А. (2015). Condition of non-specific resistence indices in patients suffering from eczema with different clinical course. Bukovinian Medical Herald, 19 (2 (74)), 186–188.
  17. Cork, M. J., Danby, S. G., Vasilopoulos, Y., Hadgraft, J., Lane, M. E., Moustafa, M. et. al. (2009). Epidermal Barrier Dysfunction in Atopic Dermatitis. Journal of Investigative Dermatology, 129 (8), 1892–1908. doi: http://doi.org/10.1038/jid.2009.133
  18. Borovik, T. E., Makarova, S. G., Darchiia, S. N. i dr. (2010). Kozha kak organ immunnoi sistemy. Pediatriia, 89 (2), 132–137.
  19. Levytska, S. A. (2014). Chynnyky i mekhanizmy nespetsyfichnoi rezystentnosti u ditei, shcho chasto i tryvalo khvoriiut. Klinichna ta eksperymentalna patolohiia, KhIII (2 (48)), 91–93.
  20. Dirschka, T., Reich, K., Bissonnette, R., Maares, J., Brown, T., Diepgen, T. L. (2010). An open-label study assessing the safety and efficacy of alitretinoin in patients with severe chronic hand eczema unresponsive to topical corticosteroids. Clinical and Experimental Dermatology, 36 (2), 149–154. doi: http://doi.org/10.1111/j.1365-2230.2010.03955.x
  21. Korostovcev, D. S., Makarova, I. V., Reviakina, V. A., Gorlanov, I. A. (2000). Indeks SCORAD – obektivnii i standartizovannii metod ocenki porazheniia kozhi pri atopicheskom dermatite. Allergologiia, 3, 39–43.
  22. Larsen, F. S., Hanifin, J. M. (2002). Epidemiology of atopic dermatitis. Immunology and Allergy Clinics of North America, 22 (1), 1–24. doi: http://doi.org/10.1016/s0889-8561(03)00066-3
  23. Prikaz No. 535 "Ob unifikacii mikrobiologicheskikh (bakteriologicheskikh) metodov issledovaniia, primeniaemykh v kliniko-diagnosticheskikh laboratoriiakh lechebno-profilakticheskikh uchrezhdenii" (1985). MZ SSSR, 22.04.1985, 125.
  24. Lapovets, L. Ye., Lutsyk, B. D., Lebed, H. B. et. al. (2008). Posibnyk z laboratornoi imunolohii. Lviv, 268.
  25. Iarilin, A. A. (1999). Osnovy immunologii. Moscow: Medicina, 608.
  26. Murzenok, P. P. et. al. (1998). Obschaia immunologiia. Minsk: OOO «Elaida», 30–38.
  27. Lapach, S. N., Chubenko, A. V., Babich, P. N. (2002). Osnovnye principy primeneniia statisticheskikh metodov v klinicheskikh ispytaniiakh. Kyiv: Morion, 160.

Published

2019-01-30

How to Cite

Dzhoraeva, S. (2019). Сondition of indicators of antimicrobial resistance in patients with allergic dermatoses complicated by staphylococcal infection, depending on the severity of the diseases. ScienceRise: Medical Science, (1 (34), 35–40. https://doi.org/10.15587/2519-4798.2020.193201

Issue

Section

Medical Science