Long-term results of combined treatment of triple-negative breast cancer

Authors

  • Yuriy Vinnyk Kharkiv Medical Academy of Postgraduate Education Amosova str., 58, Kharkiv, Ukraine, 61176, Ukraine
  • Vadim Vlasenko Molecule Medical Center Hoholia str., 7, Kharkiv, Ukraine, 61057, Ukraine https://orcid.org/0000-0002-8215-1958
  • Anna Baranova Kharkiv Medical Academy of Postgraduate Education Amosova str., 58, Kharkiv, Ukraine, 61176 State Institution « S. P. Grigoriev Institute of Medical Radiology of National Academy of Medical Sciences of Ukraine » Pushkinska str., 82, Kharkiv, Ukraine, 61024, Ukraine https://orcid.org/0000-0002-2419-9910

DOI:

https://doi.org/10.15587/2519-4798.2020.203371

Keywords:

triple negative breast cancer, radical surgery, combination treatment, long-term outcome, neoadjuvant chemotherapy

Abstract

The most dangerous immunohistochemical type of breast cancer is the triple-negative type. This subtype is detected in 10-20 % of breast cancer cases and is characterized by an aggressive clinical course with high proliferative activity and growth rate, which leads to more active surgical tactics and systemic treatment.

The aim of the study was to study the long-term results of the combined treatment of triple-negative type of breast cancer in comparison with other immunohistochemical types.

Materials and methods. The treatment results of 140 women with breast cancer who underwent radical surgery and were available for contact after 6 months and more after the operation were analyzed depending on the initial clinical and pathological parameters and treatment features using the methods of descriptive statistics, χ2 criterion and correlation analysis, survival tables and the Kaplan-Meier method.

Results. During the analyzed period, distant metastases were detected in 5 (3.6 %), locoregional recurrence in 15 (10.7 %), 12 (8.6 %) patients died. Long-term results with triple-negative type of breast cancer are worse than with luminal forms. A significant dependence of survival on neoadjuvant chemotherapy was revealed. Radiation therapy, the volume of surgery (radical resection or radical mastectomy), breast reconstruction did not significantly affect the long-term result of treatment.

Conclusion. Triple-negative type of breast cancer has the worst long-term results with an increase in the frequency of distant and locoregional metastases and a decrease in overall and relapse-free survival compared with luminal types. After neoadjuvant chemotherapy, the frequency of locoregional relapses decreases and the life expectancy of patients increases

Author Biographies

Yuriy Vinnyk, Kharkiv Medical Academy of Postgraduate Education Amosova str., 58, Kharkiv, Ukraine, 61176

MD, Professor, Head of Department

Department of Oncological Surgery, Radiation Therapy and Palliative Care

Vadim Vlasenko, Molecule Medical Center Hoholia str., 7, Kharkiv, Ukraine, 61057

PhD

Anna Baranova, Kharkiv Medical Academy of Postgraduate Education Amosova str., 58, Kharkiv, Ukraine, 61176 State Institution « S. P. Grigoriev Institute of Medical Radiology of National Academy of Medical Sciences of Ukraine » Pushkinska str., 82, Kharkiv, Ukraine, 61024

Postgraduate Student

Department of Oncological Surgery, Radiation Therapy and Palliative Care

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Published

2020-05-31

How to Cite

Vinnyk, Y., Vlasenko, V., & Baranova, A. (2020). Long-term results of combined treatment of triple-negative breast cancer. ScienceRise: Medical Science, (3 (36), 33–37. https://doi.org/10.15587/2519-4798.2020.203371

Issue

No. 3 (36) (2020)

Section

Medical Science

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Copyright (c) 2020 Yuriy Vinnyk, Vadim Vlasenko, Anna Baranova

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