Purins dysmetabolism in patient with gout and its association with dysadipokinemia

Authors

DOI:

https://doi.org/10.15587/2519-4798.2018.127004

Keywords:

gout, leptin, adyponectin, adyponectin / leptin ratio, uric acid metabolism

Abstract

Aim of the research was the study of the features of the exchange of urea acid in patients with gout and assessment of their connection with disadypokinemia.

Materials and methods. In the study took part 151 patients with gout and 31 person from control group. The level of uric acid in the serum of blood and urine was determined by the biochemical method, the level of leptin and adyponectin by the enzyme-linked immunosorbent assay. The evaluation of the correlation between uric acid metabolism and disadypokinemia was performed using the Pearson correlation coefficient. Student's t-criterion was used to assess the differences between the groups.

Results. It turned out that in patients with gout there is a significant increase in the level of UA in the blood, lower clearance of UA and low fractional excretion compared with the control group. Disadypokinemia was also more pronounced in the group of patients with gout. In subjects with severe disadypokinemia, higher values of hyperuricemia were observed, a significantly lower excretion of UA with urine, reduced clearance and fractional excretion of UA.

Conclusions. Patients with gout have a rise in uricemia with reduced clearance and fractional excretion of UA. An associative connection between adypokin status in patients with gout and urinary acid metabolism was established

Author Biographies

Inna Orlova, National Pirogov Memorial Medical University Pyrohova str., 56, Vinnytsya, Ukraine, 21018

Postgraduate Student

Department of Internal Medicine No. 1

Mykola Stanislavchuk, National Pirogov Memorial Medical University Pyrohova str., 56, Vinnytsya, Ukraine, 21018

MD, Professor, Head of Department

Department of Internal Medicine No. 1

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Published

2018-03-27

How to Cite

Orlova, I., & Stanislavchuk, M. (2018). Purins dysmetabolism in patient with gout and its association with dysadipokinemia. ScienceRise: Medical Science, (3 (23), 18–22. https://doi.org/10.15587/2519-4798.2018.127004

Issue

No. 3 (23) (2018)

Section

Medical Science

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Copyright (c) 2018 Inna Orlova, Mykola Stanislavchuk

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