The role of adhesive and cytokine signaling systems in the pathogenesis of persistent post-eradication urethritis in men, induced by c. trachomatis, u. urealyticum, m. genitalium


  • M.R. Anfilova Vinnitsa National Medical University N.I. Pirogova, Ukraine



acute non-gonococcal urethritis, immune response, persistence, urethral epithelium, cytokines, intercellular adhesion molecules, C. trachomatis, U. urealyticum, M. genitalium


The purpose of the study was to investigate the role of soluble intercellular adhesion molecules (ICAM-1, VCAM) in the pathogenesis of persistent non-gonococcal urethritis in men induced by C.trachomatis, U.urealyticum, M. genitalium and to determine their possible association with the content of cytokines in urethral cytokines (IL -6, IL-8). Conclusions: Cytokines with chemokine activity (IL-6, IL-8) and soluble intercellular adhesion molecules (ICAM-1, VCAM) are key factors in the pathogenesis of persistent post-eradication urethritis, which is confirmed by statistically significant differences in the median concentrations of these mediators between patients with persistence Symptoms and clinical cure. Cytokines (IL-6, IL-8) and adhesive molecules (ICAM-1, VCAM) have synergistic effects that promote the recruitment and deposition of immunocompetent cells, as indicated by the presence of a correlation between the concentrations of these mediators. Further studies should be aimed at establishing mechanisms for the development of specific symptoms and ways to correct them.


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