Roman Lesyk

Danylo Halytsky Lviv National Medical University, Ukraine
PhD, DSc, professor, Head of Department of Pharmaceutical, Organic and Bioorganic Chemistry

Scopus profile: link
Researcher ID: A-3395-2015
GoogleScholar profile: link
ID ORCID: http://orcid.org/0000-0002-3322-0080

Professional (scientific) interests: medicinal and organic chemistry.

Selected Publications:

  1. Podolak, M., Holota, S., Deyak, Y., Dziduch, K., Dudchak, R., Wujec, M., Bielawski, K., Lesyk, R., Bielawska, A. (2024). Tubulin inhibitors. Selected scaffolds and main trends in the design of novel anticancer and antiparasitic agents. Bioorganic Chemistry, 143, 107076. https://doi.org/10.1016/j.bioorg.2023.107076

  2. Pyrih, A., Łapiński, A., Zięba, S., Mizera, A., Lesyk, R., Gzella, A. K., Jaskolski, M. (2024). Proton tautomerism and stereoisomerism in isomeric 4-(metoxyphenyl)amino-1,3-thiazol-2(5H)-one derivatives: Synthesis, crystal structure and spectroscopic studies. Journal of Molecular Structure, 1295, 136748. https://doi.org/10.1016/j.molstruc.2023.136748

  3. Chen, Y., Pan, W., Ding, X., Zhang, L., Xia, Q., Wang, Q., Chen, Q., Gao, Q., Yan, J., Lesyk, R., Tang, Z., Han, X. (2023). Design, synthesis, and anticancer evaluation of nitrobenzoxadiazole-piperazine hybrids as potent pro-apoptotic agents. Tetrahedron, 138, 133393. doi: https://doi.org/10.1016/j.tet.2023.133393

  4. Sysak, S., Czarczynska-Goslinska, B., Szyk, P., Koczorowski, T., Mlynarczyk, D. T., Szczolko, W., Lesyk, R., Goslinski, T. (2023). Metal Nanoparticle-Flavonoid Connections: Synthesis, Physicochemical and Biological Properties, as Well as Potential Applications in Medicine. Nanomaterials, 13 (9), 1531. doi: https://doi.org/10.3390/nano13091531

  5. Ivasechko, I., Lozynskyi, A., Senkiv, J., Roszczenko, P., Kozak, Y., Finiuk, N., Klyuchivska, O., Kashchak, N., Manko, N., Maslyak, Z., Lesyk, D., Karkhut, A., Polovkovych, S., Czarnomysy, R., Szewczyk, O., Kozytskiy, A., Karpenko, O., Khyluk, D., Gzella, A., Lesyk, R. et al. (2023). Molecular design, synthesis and anticancer activity of new thiopyrano[2,3-d]thiazoles based on 5-hydroxy-1,4-naphthoquinone (juglone). European Journal of Medicinal Chemistry, 252, 115304. doi: https://doi.org/10.1016/j.ejmech.2023.115304

  6. Gornowicz, A., Lesyk, R., Czarnomysy, R., Holota, S., Shepeta, Y., Popławska, B., Podolak, M., Szymanowski, W., Bielawski, K., Bielawska, A. (2023). Multi-Targeting Anticancer Activity of a New 4-Thiazolidinone Derivative with Anti-HER2 Antibodies in Human AGS Gastric Cancer Cells. International Journal of Molecular Sciences, 24 (7), 6791. doi: https://doi.org/10.3390/ijms24076791

  7. Pecquet, C., Papadopoulos, N., Balligand, T., Chachoua, I., Tisserand, A., Vertenoeil, G., Nédélec, A., Vertommen, D., Roy, A., Marty, C., Nivarthi, H., Defour, J.-P., El-Khoury, M., Hug, E., Majoros, A., Xu, E., Zagrijtschuk, O., Fertig, T. E., Marta, D. S., Constantinescu, S. N., Lesyk, R. et al. (2023). Secreted mutant calreticulins as rogue cytokines in myeloproliferative neoplasms. Blood, 141(8), 917–929. doi: https://doi.org/10.1182/blood.2022016846