Efficacy of complex treatment of acute necrotic pancreatitis using antibacterial drugs and polyvalent piobacteriophag
Keywords:bacteriophages, acute necrotic pancreatitis, antibacterial preparations, bacteria, microflora, complex treatment
Among surgical diseases of the abdominal cavity, acute necrotic pancreatitis is important. The total lethality in this disease is 4.28 - 5.50 %, and with its destructive forms in the postoperative period, it reaches 20 - 40 % [1,2,3]. The number of cases in which the development of the disease involved antibiotic resistant microorganisms significantly increased. In this regard, the treatment of acute necrotic pancreatitis needs improvement.
Aim. Improvement of the treatment of patients with acute necrotizing pancreatitis with the complex application of polyvalent pyobacteriofag and antibacterial preparations.
Method. A bacteriological study was performed on patients with acute necrotic pancreatitis, in which 49 strains of microorganisms were isolated from the manure both in the control and the basic (experimental) group. For the treatment of acute necrotic pancreatitis, antibiotics were used in conjunction with polyvalent pyobacteriofag (main group). Only antibiotics were used to treat patients in the control group.
Main results. In the experimental group of patients with acute necrotic pancreatitis, associations of microorganisms that were acting together with antibiotics and polyvalent pyobacteriophag were isolated.
According to the data obtained, the use of antibiotics, in combination with polyvalent pyobacteriophage in the complex treatment of purulent necrotic pancreatitis, accelerated healing of surgical wounds and recovery of patients.
Thus, the data that were obtained as a result of the complex treatment of acute necrotic pancreatitis with the use of antibiotics and polyvalent pyobacteriophag purified, indicate that the treatment of patients in the main group, compared with the control, was more effective.
Conclusions. The use of the complex therapy with an antibiotic with polyvalent piobacteriofag reduces the cost of the treatment, which has an important social and economic significance.
It has been proved that the use of polyvalent piobactyrophag, together with antibiotics in the complex treatment of acute necrotic pancreatitis, reduced the duration of the treatment to 39 ± 4, and with the use of antibiotics alone, treatment continued for 42 ± 6 years.
With the use of this technique, patients’ wound healing was at 6 ± 2 days, while at the treatment with antibiotics only wound was cleared by 12 ± 3
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