Determination of the anticancer properties of cis- and trans-diadamanthylcarboxylates of dirhenium(III)
DOI:
https://doi.org/10.15587/2519-8025.2020.217554Keywords:
dirhenium(III) cluster compounds, adamantanecarboxylic acid, cisplatin, model of tumor growth, Calf Thymus DNA, antiradical activityAbstract
The aim of the study. The aim of the work was to investigate in vivo anticancer activity of cis- and trans-diadamanthylcarboxylates of dirhenium(III) alone and together with cisplatin in form of nanobins.
Materials and methods. Model of tumor growth, Guerin’s carcinoma; intraperitoneal administration of cisplatin, dirhenium(III) compounds in liposomes and of binary liposomes, containing both cytostatics; volumes and final weights of tumors were measured.
Results. In vivo antitumor properties of two dirhenium(III) dicarboxylates with 1-adamantanecarboxylic acid moieties as ligands with cis- (I) and trans- (II) orientation of the carboxylic groups around a cluster fragment alone and together with cisplatin were presented; an attempt to understand differences in a possible mechanism of anticancer activity of the substances were undertaken. Antiradical and DNA-binding properties of I and II were the matter of consideration.
Conclusions. Cis- and trans- compounds of dirhenium I and II had close antitumor activity in vivo with a little bit superiority of the cis- analog. Mechanisms of anticancer activity of I and II are different and may also include monofunctional adduct formation and subsequent interstrand cross-linking for the II substance, formation of protein-DNA cross-links, etc.
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Copyright (c) 2020 Natalia Shtemenko, Katerina Polokhina, Alexander Golichenko, Svetlana Babiy, Alexander Shtemenko
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