Development of mask-cream technology with herbal substances for the androgenic alopecia treatment

Authors

DOI:

https://doi.org/10.15587/2519-4852.2017.103544

Keywords:

mask-cream, androgenic alopecia, Sabal palm extract, Sophora japonica tincture, technology

Abstract

Aim. The aim of the study was to develop a rational technology of mask-cream containing Sabal palm extract and Sophora japonica tincture applied for prevention and tratment of androgenic alopecia.

Methods. Pharmaco-technological, physico-chemical, rheological and microscopy methods were used.

Results. Using microscopy studies aimed to determine the dispersion of the oil phase particles of the mask-cream it was found that the largest percentage of emulsion drops of up to 4 μm, in particular 74.4 %, was in the sample produced by reverse emulsion method. The given sample was characterized by the structural viscosity value at 20 ºС and 20 rpm – 9060 mPa·Sec, which was close to the carrier base viscosity. The increase of homogenization speed and period sufficiently reduced the average size of the dispersed phase only to a certain point, therefore, optimal parameters for the cream-mask homogenization were chosen – 2000 rpm, within 20 minutes.

The active substances (Sabal palm extract, Sophora japonica tincture) and the excipients (preservatives, thickener, flavor) were put into the base gradually, concerning their physical and chemical properties.

Conclusion. Technological parameters of the mask-cream preparation using emulsion base were determined: reverse emulsion method, homogenization parameters – 20 minutes at 2000 rpm. Technological scheme for production of the mask-cream containing Sabal palm extract and Sophora japonica tincture was developed

Author Biographies

Maryana Fedorovska, Ivano-Frankivsk National Medical University Halytska str., 2, Ivano-Frankivsk, Ukraine, 76018

PhD, Associate Professor

Department of Organization and Economics in Pharmacy and Technology 

Natalia Polovko, National University of Pharmacy Pushkinska str., 53, Kharkiv, Ukraine, 61002

Doctor of Pharmaceutical Science, Professor

Department of Drug Technology

Natalia Leochko, Ivano-Frankivsk National Medical University Halytska str., 2, Ivano-Frankivsk, Ukraine, 76018

PhD, Associate Professor

Department of Chemistry of Pharmaceutical Faculty

References

  1. Gadzhygoroyeva, A. G. (2013). Topicheskaya modifikatsiya metabolizma testosterona pri lechenii androgennoy alopetsii. Nauchno-prakticheskoye obshchestvo vrachey kosmetologov Sankt-Peterburga, 14, 70–75.
  2. Mareyeva, A. N. (2011). Osobennosti klinicheskih proyavleniy androgennoy alopetsii u zhenshchin reproduktivnogo vozrasta. Vestnik dermatologii i venerologii, 1, 103–107.
  3. Ali Mapar, M., Omidian, M. (2007). Is topical minoxidil solution effective on androgenetic alopecia in routine daily practice? Journal of Dermatological Treatment, 18 (5), 268–270. doi: 10.1080/09546630701383727
  4. Yarema, I. O., Fedorovska, M. I., Sokolova, L. V. (2014). Marketyngovi doslidzhennya rynku likars’kyh ta kosmetychnyh zasobiv pryznachenyh dlya zastosuvannya pry riznyh formah alopetsii. Aktualni pytannya farmatsevtychnoi i medychnoi nauky i praktyky, 3 (16), 106–110.
  5. Baranova, I. I., Bashura, O. G., Gladuh, Ye. V. (2010). Obgruntuvanya skladu i tehnologii gelu-masky z bodyagoyu. Visnyk farmatsii, 4, 15–18.
  6. Yurchenko, B. Ye., Polovko, N. P., Kovaleva, T. N. (2013). Razrabotka technologii krema Metroksal. Vestnik farmatsii, 4 (62), 5–11.
  7. Fedorovska, M. I. (2014). Rozrobka skladu osnovy krem-masky dlya profilaktyky i terepii osib z androgennoyu alopetsiyeyu. Aktualni pytannya farmatsevtychnoi i medychnoi nauky i praktyky, 2, 4–7.
  8. Yarema, I. O., Fedorovska, M. I., Kutsyk, R. V. (2016). Obgruntuvannya vyboru antymikrobnuh konservantiv pry rozrobci preperativ dlya mistsevogo likuvannya androgennoi alopetsii. Odeskyi medychnyi zhurnal, 2 (154), 20–24.
  9. Gorlachova, V. I., Vyshnevska, L. I. (2016). Development of technology for manufacture of cream with wild carrot seeds lipophilic extract for burn wounds treatment. ScienceRise, 2 (4 (19)), 51–57. doi: 10.15587/2313-8416.2016.62872
  10. Fedorovska, M. I. Yarema, I. O. (2015). Technology development of herbal remedies for androgenic alopecia external application. The Pharma Innovation Journal, 4 (8), 26–28.

Published

2017-06-27

How to Cite

Fedorovska, M., Polovko, N., & Leochko, N. (2017). Development of mask-cream technology with herbal substances for the androgenic alopecia treatment. ScienceRise: Pharmaceutical Science, (3 (7), 19–24. https://doi.org/10.15587/2519-4852.2017.103544

Issue

Section

Pharmaceutical Science