Development of method for qualitative analysis of corn silk for implementation in the state pharmacopoeia of Ukraine draft national monograph
DOI:
https://doi.org/10.15587/2519-4852.2017.103906Keywords:
the State Pharmacopoeia of Ukraine, Corn silk, sterines, flavonoidsAbstract
According to the concept of development and implementation of monographs on herbal material into the State Pharmacopoeia of Ukraine, Corn silk is included into the list of herbal material, which is described in the State Pharmacopoeia USSR XI edition and is absent in European Pharmacopoeia. Therefore, development of the national monograph on this herb is relevant. It was mentioned before, that in the State Pharmacopoeia USSR XI edition modern methods for identification of biologically active compounds of the given herb are absent, and identification is performed only by macroscopic and microscopic diagnostic features.
Aim. Development of methods for identification of Corn silk by thin-layer chromatography, harmonized with the State Pharmacopoeia of Ukraine requirements concerning herbal material for the further implementation into the draft national monograph “Corn silk".
Methods. To reach the goal, unified methods for phenol compounds and sterines analysis by thin-layer chromatography were used.
Results. Due to chemical composition, medicinal use and approaches to the standardization, sterines and flavonoids were selected for identification by thin-layer chromatography. The methods development was carried out simultaneously with their validation according to the State Pharmacopoeia of Ukraine General Chapter requirements.
Conclusion. Prerequisites for development of “Identification” part were substantiated for implementation to the State Pharmacopoeia of Ukraine monograph “Corn silk”. Methods for identification of sterines and flavonoids by thin-layer chromatography were developed. The analysis of different samples of Corn silk was carried out using thin-layer chromatography method under the developed conditions. The possibility of parts “Identification C” and “Identification D” implementation into the draft national monograph “Corn silk” using the developed thin-layer chromatography methods was proved
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