DOI: https://doi.org/10.15587/2519-4852.2017.109254

Development and standardization of test systems based on filter paper and modified with vanillin reagent

Vadim Prokopets, Oleksandr Zdoryk, Viktoria Georgiyants

Abstract


 

Reagents and analytical tools for rapid analysis should be standardized and lead to the requirements of the State Pharmacopoeia of Ukraine. Newsprint paper is used as the main analytical tool for rapid analysis of substances with primary aromatic amino group, but it can’t be standardized. The development of test systems based on filter paper and modified with pharmacopeia reagents can be the problem solution.

Aim. The aim of the work is development and implementation of test-kits based on filter paper for rapid analysis of compounded preparations that contain primary aromatic amino group in conditions of pharmacies.

Methods. Methods of physical immobilization; determination of physical stability of test kits; economic and statistical methods (cost calculation); validation of analytical methods; statistical methods of data processing chemical experiment.

Results. Filter paper and pharmacopeia solution of vanillin were used to develop test systems; the possibility of using the test system in practice was investigated with the application of rapid analysis of sulfacetamide and sulfathiazole sodium. The possibility of using of the test system for rapid analysis of 5% aqueous solutions of derivatives of sulfanilic acid amides has been proved; the following detection limits and unreliability intervals for the rapid analysis method using test systems were established: 5.0-9.0 mg/ml for sodium sulfacetamide and 5.3-9.6 mg/ml for sodium sulfathiazole. The test system is stable during 5 months of storage. Manufacturing cost of 1 test system is 0.34 and 0.16 UAH for the first and the next batches, respectively.

Conclusions. The proposed test system is stable and accessible for usage in pharmacy as an analytical tool for rapid analysis of derivatives of sulfanilic acid amides


Keywords


extemporaneous preparations; chemical test-kits; rapid analysis; lignin test; sulfacetamide sodium; sulfathiazole sodium

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References


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GOST Style Citations


Gainey Wilson, K. A Low-Cost Inkjet-Printed Glucose Test Strip System for Resource-Poor Settings [Text] / K. Gainey Wilson, P. Ovington, D. Dean // Journal of Diabetes Science and Technology. – 2015. – Vol. 9, Issue 6. – P. 1275–1281. doi: 10.1177/1932296815589755

Landis, B. N. “Taste Strips” – A rapid, lateralized, gustatory bedside identification test based on impregnated filter papers [Text] / B. N. Landis, A. Welge-Luessen, A. Bramerson, M. Bende, C. A. Mueller, S. Nordin, Hummel, T. // Journal of Neurology. – 2009. – Vol. 256, Issue 2. – P. 242–248. doi: 10.1007/s00415-009-0088-y

Hossain, S. M. Z. Multiplexed paper test strip for quantitative bacterial detection [Text] / S. M. Z. Hossain, C. Ozimok, C. Sicard, S. D. Aguirre, M. M. Ali, Y. Li, J. D. Brennan // Analytical and Bioanalytical Chemistry. – 2012. – Vol. 403, Issue 6. – P. 1567–1576. doi: 10.1007/s00216-012-5975-x

Das, J. Low-cost field test kits for arsenic detection in water [Text] / J. Das, P. Sarkar, J. Panda, P. Pal // Journal of Environmental Science and Health. – 2013. – Vol. 49, Issue 1. – P. 108–115. doi: 10.1080/10934529.2013.824764

Malahom, N. Simple test kit based on colorimetry for quantification of magnesium content in natural rubber latex by miniaturized complexometric titration without using masking agent [Text] / N. Malahom, P. Jarujamrus, R. Meelapsom, A. Siripinyanond, M. Amatatongchai, S. Chairam // Polymer Testing. – 2017. – Vol. 59. – 160–167. doi: 10.1016/j.polymertesting.2017.01.023

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ISSN 2519-4852 (Online), ISSN 2519-4844 (Print)