Actual approaches to development of new germicides in the conditions of extension of antibiotic resistance

Authors

  • Svіtlana Bilous Danylo Halytsky Lviv National Medical University Pekarska str., 69, Lviv, Ukraine, 79010, Ukraine https://orcid.org/0000-0002-1682-5352
  • Svitlana Dуbkova F. D. Ovcharenko Institute of Biocolloidal Chemistry National Academy of Sciences of Ukraine Akademika Vernadskoho blvd., 42, Kyiv, Ukraine, 03142, Ukraine https://orcid.org/0000-0002-8580-2584
  • Olga Liutko State Institution “Institute of Traumatology and Orthopaedics of National Academy of Medical Sciences of Ukraine” Bulvarno-Kudriavska str., 27, Kyiv, Ukraine, 01601, Ukraine https://orcid.org/0000-0001-8233-3041
  • Liudmyla Rieznichenko F. D. Ovcharenko Institute of Biocolloidal Chemistry National Academy of Sciences of Ukraine Akademika Vernadskoho blvd., 42, Kyiv, Ukraine, 03142, Ukraine https://orcid.org/0000-0002-3652-4426
  • Tamara Gruzina F. D. Ovcharenko Institute of Biocolloidal Chemistry National Academy of Sciences of Ukraine Akademika Vernadskoho blvd., 42, Kyiv, Ukraine, 03142, Ukraine https://orcid.org/0000-0002-7613-7391
  • Tymofiy Kalyniuk Danylo Halytsky Lviv National Medical University Pekarska str., 69, Lviv, Ukraine, 79010, Ukraine https://orcid.org/0000-0002-6181-5938

DOI:

https://doi.org/10.15587/2519-4852.2018.122169

Keywords:

antimicrobial preparations, nanoparticles of metals, infectious diseases, microbial resistance, elimination of plasmids

Abstract

Aim. The grounding of expediency of studying the nature of interaction between metal nanoparticles and plasmid DNA of bacteria at the stage of pharmaceutical development of antimicrobial preparations based on metal nanoparticles as separate antimicrobial agents, as well as compositions of metal nanoparticles with known antimicrobial substances.

Methods. Methods of information retrieval and analysis of literature data have been used.

Results. Plasmid transmission of drug resistance is the most important mechanism of resistance in the bacterial population. A promising approach to solve the problem of overcoming the resistance of microorganisms is the use as an active pharmaceutical ingredient of antimicrobial agents caused the destruction of R-plasmids or ensured their irreversible elimination. The study of the interaction of substances with plasmid DNA bacteria and the study of their effect on the transfer of resistance genes in bacterial populations should be used at the first stage of the creation of antimicrobial preparations, when a potential active pharmaceutical ingredient is select.

Conclusion. Creation and introduction into the production of medicines based on silver and gold nanoparticles is a promising direction, because nanoparticles of these metals, along with antimicrobial action, will provide irreversible elimination of plasmid from bacterial cells and can become a solution of the problem with antibiotic resistance

Author Biographies

Svіtlana Bilous, Danylo Halytsky Lviv National Medical University Pekarska str., 69, Lviv, Ukraine, 79010

PhD, Associate Professor

Department of Drug Technology and Biopharmaceutics

Svitlana Dуbkova, F. D. Ovcharenko Institute of Biocolloidal Chemistry National Academy of Sciences of Ukraine Akademika Vernadskoho blvd., 42, Kyiv, Ukraine, 03142

PhD, Senior Researcher

Department of colloidal technology of natural systems

Olga Liutko, State Institution “Institute of Traumatology and Orthopaedics of National Academy of Medical Sciences of Ukraine” Bulvarno-Kudriavska str., 27, Kyiv, Ukraine, 01601

PhD

Laboratory of Microbiology and Chemotherapy

Liudmyla Rieznichenko, F. D. Ovcharenko Institute of Biocolloidal Chemistry National Academy of Sciences of Ukraine Akademika Vernadskoho blvd., 42, Kyiv, Ukraine, 03142

PhD

Department of colloidal technology of natural systems

Tamara Gruzina, F. D. Ovcharenko Institute of Biocolloidal Chemistry National Academy of Sciences of Ukraine Akademika Vernadskoho blvd., 42, Kyiv, Ukraine, 03142

PhD, Senior Researcher

Department of colloidal technology of natural systems

Tymofiy Kalyniuk, Danylo Halytsky Lviv National Medical University Pekarska str., 69, Lviv, Ukraine, 79010

Doctor of Pharmaceutical Sciences, Professor

Department of Drug Technology and Biopharmaceutics

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Published

2018-01-31

How to Cite

Bilous, S., Dуbkova S., Liutko, O., Rieznichenko, L., Gruzina, T., & Kalyniuk, T. (2018). Actual approaches to development of new germicides in the conditions of extension of antibiotic resistance. ScienceRise: Pharmaceutical Science, (1 (11), 12–15. https://doi.org/10.15587/2519-4852.2018.122169

Issue

No. 1 (11) (2018)

Section

Pharmaceutical Science

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Copyright (c) 2018 Svіtlana Bilous, Svitlana Dуbkova, Olga Liutko, Liudmyla Rieznichenko, Tamara Gruzina, Tymofiy Kalyniuk

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