Brain cortex activation during the execution of the motor task in subjects with acute cerebrovascular accident

Authors

  • Oleksii Omelchenko Educational and Scientific Center "Institute of Biology and Medicine" of Taras Shevchenko National University of Kyiv Volodymyrska str., 64/13, Kyiv, Ukraine, 01601, Ukraine https://orcid.org/0000-0002-0089-3166
  • Mykola Makarchuk Educational and Scientific Center "Institute of Biology and Medicine" of Taras Shevchenko National University of Kyiv Volodymyrska str., 64/13, Kyiv, Ukraine, 01601, Ukraine https://orcid.org/0000-0002-0982-3463

DOI:

https://doi.org/10.15587/2519-8025.2018.132992

Keywords:

brain, acute cerebrovascular accident, functional MRI, motor cortex

Abstract

We propose the analysis of the peculiarities of the hemodynamic fMRI response in healthy subjects and in acute cerebrovascular accident patients under the movement execution for evaluation of fMRI brain cortex mapping applicability in acute stroke. Five groups of patients were studied with fMRI: first group consisted of 18 healthy subjects, second group consisted of 3 stroke patients with the left hemisphere central sulcus lesion location, third group consisted of 3 patients with the left hemisphere periventricular white matter lesion location, fourth group consisted of 3 patients with the right cerebellar hemisphere lesion location, fifth groups consisted of 2 stroke patients with the left hemisphere supramarginal gyrus lesion location. Right hand finger tapping task was used for the fMRI activation. Data was analyzed with the FSL software. Common regions of activation were located at the contralateral primary sensorimotor cortex, supplementary motor area and cerebellum. Additional regions of activation in stroke patients were located at the ipsilateral sensorimotor cortex, fronto-parietal and premotor cortex, bilateral cerebellum, and the subthalamic nuclei. Stroke-related migration of the activation regions in the supramarginal gyrus and ventral premotor cortex of the mirror neuron system was found during the audio-motor transformation. Regions of brain activation were found adjacent to the DWI hyper intense ischemic regions during the movement execution. But at the most DWI hyperintense focuses no fMRI activation was found.  We have found out correlation of the maximal BOLD signal amplitude change and the total volume of brain activation. It was shown that fMRI allows visualization of the main cortical motor control regions in acute stroke. Additional regions of cortical motor control have to be involved in acute stroke. Adjacent to the DWI hyper intense regions of activation were found

Author Biographies

Oleksii Omelchenko, Educational and Scientific Center "Institute of Biology and Medicine" of Taras Shevchenko National University of Kyiv Volodymyrska str., 64/13, Kyiv, Ukraine, 01601

Postgraduate Student

Department of Physiology and Anatomy

Mykola Makarchuk, Educational and Scientific Center "Institute of Biology and Medicine" of Taras Shevchenko National University of Kyiv Volodymyrska str., 64/13, Kyiv, Ukraine, 01601

Doctor of Biological Sciences, Professor

Department of Physiology and Anatomy

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Published

2018-06-05

How to Cite

Omelchenko, O., & Makarchuk, M. (2018). Brain cortex activation during the execution of the motor task in subjects with acute cerebrovascular accident. ScienceRise: Biological Science, (3 (12), 4–11. https://doi.org/10.15587/2519-8025.2018.132992

Issue

No. 3 (12) (2018)

Section

Biological Sciences

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Copyright (c) 2018 Oleksii Omelchenko, Mykola Makarchuk

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