Radiation-induced chromosome aberrations in oncogynecological patients and patients with head and neck cancer undergoing radiotherapy on a linear accelerator

Authors

  • Nataliya Maznyk State Institution «Grigoriev Institute for Medical Radiology of National Academy of Medical Science of Ukraine» Pushkinska str., 82, Kharkiv, Ukraine, 61024, Ukraine https://orcid.org/0000-0002-3216-1330
  • Tetiana Sypko State Institution «Grigoriev Institute for Medical Radiology of National Academy of Medical Science of Ukraine» Pushkinska str., 82, Kharkiv, Ukraine, 61024, Ukraine https://orcid.org/0000-0002-1788-9235
  • Tetiana Sypko State Institution «Grigoriev Institute for Medical Radiology of National Academy of Medical Science of Ukraine» Pushkinska str., 82, Kharkiv, Ukraine, 61024, Ukraine https://orcid.org/0000-0002-1788-9235
  • Nataliya Pshenichna State Institution «Grigoriev Institute for Medical Radiology of National Academy of Medical Science of Ukraine» Pushkinska str., 82, Kharkiv, Ukraine, 61024, Ukraine https://orcid.org/0000-0002-6119-1117
  • Nataliya Pshenichna State Institution «Grigoriev Institute for Medical Radiology of National Academy of Medical Science of Ukraine» Pushkinska str., 82, Kharkiv, Ukraine, 61024, Ukraine https://orcid.org/0000-0002-6119-1117
  • Viktor Starenkiy State Institution «Grigoriev Institute for Medical Radiology of National Academy of Medical Science of Ukraine» Pushkinska str., 82, Kharkiv, Ukraine, 61024, Ukraine https://orcid.org/0000-0002-6600-3381
  • Viktor Starenkiy State Institution «Grigoriev Institute for Medical Radiology of National Academy of Medical Science of Ukraine» Pushkinska str., 82, Kharkiv, Ukraine, 61024, Ukraine https://orcid.org/0000-0002-6600-3381
  • Iryna Krugova State Institution «Grigoriev Institute for Medical Radiology of National Academy of Medical Science of Ukraine» Pushkinska str., 82, Kharkiv, Ukraine, 61024, Ukraine https://orcid.org/0000-0002-6676-3321
  • Iryna Krugova State Institution «Grigoriev Institute for Medical Radiology of National Academy of Medical Science of Ukraine» Pushkinska str., 82, Kharkiv, Ukraine, 61024, Ukraine https://orcid.org/0000-0002-6676-3321

DOI:

https://doi.org/10.15587/2519-8025.2018.133392

Keywords:

radiation-induced chromosome aberrations, lymphocytes, oncological patients, megavolt radiation therapy

Abstract

Aims: The assessment of radiation-induced chromosome aberrations in lymphocytes of oncogynecological and head and neck cancer patients during radiation therapy on linear accelerator depending on the tumor localization.

Methods: 16 oncogynecological patients and 12 patients with head and neck tumors undergoing radiation treatment on linear accelerator were examined. Lymphocytes were cultivated by the conventional technique before treatment, in the middle and at the end of the radiotherapy course. Radiation doses exceeded 40–44 Gy.

Results of research: The yield and range of radiation-induced cytogenetic damage changes in lymphocytes during megavolt radiation therapy were demonstrated. The monotonic increase of chromosome type aberrations from start to the end of treatment was found. More pronounced changes in these parameters in oncogynecological patients than in patients with head and neck tumors were demonstrated. The range of cells with chromosome aberrations expanded during radiotherapy in both groups. In the middle of the radiotherapy cells with 1–4 aberrations per cell in head and neck cancer patients and 1–7 aberrations per cell in oncogynecological patients were observed. At the end of radiotherapy the number of damages per aberrant cell from 1 to 8 for both groups was observed. The distribution of the chromosome type aberrations among cells was found to be over-dispersed according to Poisson statistic both at the middle and at the end of radiotherapy course.

Conclusion: The study of the radiation-induced aberrations revealed the different character of cytogenetic damages accumulation in patients undergoing radiotherapy depending on tumor localizations and accordingly on the irradiated body fraction. The data obtained will expand the knowledge concerning effects of fractionated therapeutic megavolt radiation in non-tumor tissues of patients

Author Biographies

Nataliya Maznyk, State Institution «Grigoriev Institute for Medical Radiology of National Academy of Medical Science of Ukraine» Pushkinska str., 82, Kharkiv, Ukraine, 61024

Doctor of Biological Sciences, Head of Laboratory

Laboratory of Radiation Cytogenetics

Tetiana Sypko, State Institution «Grigoriev Institute for Medical Radiology of National Academy of Medical Science of Ukraine» Pushkinska str., 82, Kharkiv, Ukraine, 61024

Researcher

Laboratory of Radiation Cytogenetics

Tetiana Sypko, State Institution «Grigoriev Institute for Medical Radiology of National Academy of Medical Science of Ukraine» Pushkinska str., 82, Kharkiv, Ukraine, 61024

Researcher

Laboratory of Radiation Cytogenetics

Nataliya Pshenichna, State Institution «Grigoriev Institute for Medical Radiology of National Academy of Medical Science of Ukraine» Pushkinska str., 82, Kharkiv, Ukraine, 61024

Junior Researcher

Laboratory of Radiation Cytogenetics

Nataliya Pshenichna, State Institution «Grigoriev Institute for Medical Radiology of National Academy of Medical Science of Ukraine» Pushkinska str., 82, Kharkiv, Ukraine, 61024

Junior Researcher

Laboratory of Radiation Cytogenetics

Viktor Starenkiy, State Institution «Grigoriev Institute for Medical Radiology of National Academy of Medical Science of Ukraine» Pushkinska str., 82, Kharkiv, Ukraine, 61024

Doctor of Medical Sciences, Senior Researcher, Head of Department

Department of Radiation Therapy

Viktor Starenkiy, State Institution «Grigoriev Institute for Medical Radiology of National Academy of Medical Science of Ukraine» Pushkinska str., 82, Kharkiv, Ukraine, 61024

Doctor of Medical Sciences, Senior Researcher, Head of Department

Department of Radiation Therapy

Iryna Krugova, State Institution «Grigoriev Institute for Medical Radiology of National Academy of Medical Science of Ukraine» Pushkinska str., 82, Kharkiv, Ukraine, 61024

PhD, Senior Researcher

Department of Oncogynecology

Iryna Krugova, State Institution «Grigoriev Institute for Medical Radiology of National Academy of Medical Science of Ukraine» Pushkinska str., 82, Kharkiv, Ukraine, 61024

PhD, Senior Researcher

Department of Oncogynecology

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Published

2018-06-12

How to Cite

Maznyk, N., Sypko, T., Sypko, T., Pshenichna, N., Pshenichna, N., Starenkiy, V., Starenkiy, V., Krugova, I., & Krugova, I. (2018). Radiation-induced chromosome aberrations in oncogynecological patients and patients with head and neck cancer undergoing radiotherapy on a linear accelerator. ScienceRise: Biological Science, (3 (12), 24–28. https://doi.org/10.15587/2519-8025.2018.133392

Issue

No. 3 (12) (2018)

Section

Biological Sciences

License

Copyright (c) 2018 Nataliya Maznyk, Tetiana Sypko, Tetiana Sypko, Nataliya Pshenichna, Nataliya Pshenichna, Viktor Starenkiy, Viktor Starenkiy, Iryna Krugova, Iryna Krugova

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