Pathophysiology characteristics of the experimental model of obesity in female rats induced neonatal administration of monosodium glutamate

Authors

  • Вікторія Василівна Конопельнюк ESC "Institute of Biology and Medicine" Taras Shevchenko National University of Kyiv Volodymyrska str., 64/13, Kyiv, Ukraine, 01601, Ukraine
  • Ірина Юріївна Прибитько Educational-Scientific Center "Institute of Biology" Taras Shevchenko National University of Kyiv Volodymyrska str., 64/13, Kyiv, Ukraine, 01601, Ukraine
  • Олена Іванівна Цирюк Educational-Scientific Center "Institute of Biology" Taras Shevchenko National University of Kyiv Volodymyrska str., 64/13, Kyiv, Ukraine, 01601, Ukraine
  • Тетяна Михайлівна Фалалєєва Educational-Scientific Center "Institute of Biology" Taras Shevchenko National University of Kyiv Volodymyrska str., 64/13, Kyiv, Ukraine, 01601, Ukraine

DOI:

https://doi.org/10.15587/2519-8025.2016.83570

Keywords:

monosodium glutamate, obesity, rats, body mass index, glucose-tolerant test

Abstract

It was shown that in rats of 4 months age, the injection of monosodium glutamate elicited visceral obesity. To confirm the symptoms of obesity with type 2 diabetes, we had a glucose-tolerant test. In animals with obesityб glucose levels in 2 hours after a glucose was 10,65±2,215mmol / L, that was noted glucose intolerance

Author Biographies

Вікторія Василівна Конопельнюк, ESC "Institute of Biology and Medicine" Taras Shevchenko National University of Kyiv Volodymyrska str., 64/13, Kyiv, Ukraine, 01601

PhD, senior researcher

SRL "Physico-Chemical Biology"

Department of Experimental Biology

Ірина Юріївна Прибитько, Educational-Scientific Center "Institute of Biology" Taras Shevchenko National University of Kyiv Volodymyrska str., 64/13, Kyiv, Ukraine, 01601

PhD, Research Associate

Department of pharmacology and experimental pathology

Олена Іванівна Цирюк, Educational-Scientific Center "Institute of Biology" Taras Shevchenko National University of Kyiv Volodymyrska str., 64/13, Kyiv, Ukraine, 01601

PhD, Senior Research

Тетяна Михайлівна Фалалєєва, Educational-Scientific Center "Institute of Biology" Taras Shevchenko National University of Kyiv Volodymyrska str., 64/13, Kyiv, Ukraine, 01601

Doctor of Biological Sciences, Senior researcher, Head of department

Department of fundamental medicine

References

  1. WHO fact sheet № 311. WHO. Available at: http://www.who.int/mediacentre/factsheets/fs311/en/
  2. Pasiyeshvili, L. M., Chotoshavina, T. F. (2014). Immune imbalance as a basis for progression steatohepatitis in patients with arterial hypertension and obesity. Ukrainian therapeutical journal, 2, 40–44.
  3. Manska, K. G. (2014). Clinical characteristic of primary obesity in young women. Problems of endocrine pathology, 2, 47–52.
  4. Poirier, P. (2006). Obesity and Cardiovascular Disease: Pathophysiology, Evaluation, and Effect of Weight Loss: An Update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease From the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation, 113 (6), 898–918. doi: 10.1161/circulationaha.106.171016
  5. Falalieieva, T. M., Kukhars'kyi, V. M., Berehova, T. V. (2010). Effect of long-term monosodium glutamate administration on structure and functional state of the stomach and body weight in rats. Fiziol. Zh., 56 (4), 102–110.
  6. Insawang, T., Selmi, C., Cha’on, U., Pethlert, S., Yongvanit, P., Areejitranusorn, P. et. al. (2012). Monosodium glutamate (MSG) intake is associated with the prevalence of metabolic syndrome in a rural Thai population. Nutrition & Metabolism, 9 (1), 50. doi: 10.1186/1743-7075-9-50
  7. Castrogiovanni, D., Gaillard, R. C., Giovambattista, A., Spinedi, E. (2008). Neuroendocrine, Metabolic, and Immune Functions during the Acute Phase Response of Inflammatory Stress in Monosodium L-Glutamate-Damaged, Hyperadipose Male Rat. Neuroendocrinology, 88 (3), 227–234. doi: 10.1159/000124131
  8. Torii, K., Uneyama, H., Nakamura, E. (2013). Physiological roles of dietary glutamate signaling via gut–brain axis due to efficient digestion and absorption. Journal of Gastroenterology, 48 (4), 442–451. doi: 10.1007/s00535-013-0778-1
  9. Novelli, E. L. B., Diniz, Y. S., Galhardi, C. M., Ebaid, G. M. X., Rodrigues, H. G., Mani, F. et. al. (2007). Anthropometrical parameters and markers of obesity in rats. Laboratory Animals, 41 (1), 111–119. doi: 10.1258/002367707779399518
  10. Matysková, R., Maletínská, L., Maixnerová, J., Pirník, Z., Kiss, A., Zelezná, B. (2008). Comparison of the Obesity Phenotypes Related to Monosodium Glutamate Effect on Arcuate Nucleus and/or the High Fat Diet Feeding in C57BL/6 and NMRI Mice. Physiol. Res., 57 (5), 727–734.
  11. Savcheniuk, O. A., Virchenko, O. V., Falalyeyeva, T. M., Beregova, T. V., Babenko, L. P., Lazarenko, L. M. et. al. (2014). The efficacy of probiotics for monosodium glutamate-induced obesity: dietology concerns and opportunities for prevention. EPMA Journal, 5 (1), 2. doi: 10.1186/1878-5085-5-2
  12. Oida, K., Nakai, T., Hayashi, T. (1984). Plasma lipoproteins of monosodium glutamate-induced obese rats. International journal of obesity, 8 (5), 385–391.
  13. Stricker-Krongrad, A., Beck, B. (2004). Up-regulation of Neuropeptide Y Receptors in the Hypothalamus of Monosodium Glutamate-lesioned Sprague-Dawley Rats. Nutritional Neuroscience, 7 (4), 241–245. doi: 10.1080/10284150412331281040
  14. Kovacs, M., Kineman, R. D., Schally, A. V., Flerko, B. (2001). Increase in mRNA concentrations of pituitary receptors for growth hormone-releasing hormone and growth hormone secretagogues after neonatal monosodium glutamate treatment. Journal of Neuroendocrinology, 12 (4), 335–341. doi: 10.1046/j.1365-2826.2000.00458.x

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Published

2016-11-18

How to Cite

Конопельнюк, В. В., Прибитько, І. Ю., Цирюк, О. І., & Фалалєєва, Т. М. (2016). Pathophysiology characteristics of the experimental model of obesity in female rats induced neonatal administration of monosodium glutamate. ScienceRise: Biological Science, (3 (3), 14–18. https://doi.org/10.15587/2519-8025.2016.83570

Issue

No. 3 (3) (2016)

Section

Biological Sciences

License

Copyright (c) 2016 Вікторія Василівна Конопельнюк, Ірина Юріївна Прибитько, Олена Іванівна Цирюк, Тетяна Михайлівна Фалалєєва

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