Analysis of literature data on the relationship between vitamin D deficiency and type 1 diabetes mellitus

Authors

DOI:

https://doi.org/10.15587/2519-8025.2021.235426

Keywords:

vitamin D, type 1 diabetes mellitus, immunomodulatory and anti-inflammatory activity, pancreatic β cells

Abstract

Type 1 diabetes mellitus is a chronic autoimmune disease in which genetic predisposition and environmental factors play a major role. Vitamin D deficiency is becoming a pandemic in the world and is observed in type 1 diabetes mellitus.

The aim. Analytical review of available literature data on the relationship of vitamin D deficiency with the development and course of type 1 diabetes mellitus.

Materials and methods. Analysis of open sources of scientific literature.

Results and discussion. Clinical observations and experimental studies show that vitamin D deficiency is one of the risk factors for the development of type 1 diabetes, and is a consequence of this disease. The status of vitamin D in the body is determined not only by the intake of vitamin from the outside, but also by the activity of tissue transport and metabolism systems, which have a high degree of polymorphism. Numerous studies show the positive effect of the use of vitamin D preparations in the prevention and treatment of type 1 diabetes mellitus. However, there are works in which there is no protective effect.

Conclusions. Thus, the optimization of the status of vitamin D in the body is a promising measure to prevent the development of type 1 diabetes and facilitate its course, but requires further research.

Author Biographies

Victoriia Fylymonenko, National University of Pharmacy

PhD, Associate Professor

Department of Biological Chemistry

Liubov Galuzinska, National University of Pharmacy

PhD, Associate Professor

Department of Biological Chemistry

Tetiana Briukhanova, National University of Pharmacy

PhD, Assistant

Department of Biological Chemistry

Olena Chumak, National University of Pharmacy

Assistant

Department of Biological Chemistry

Olena Yatsenko, National University of Pharmacy

PhD, Associate Professor

Department of Normal and Pathological Physiology

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Published

2021-06-30

How to Cite

Fylymonenko, V., Galuzinska, L., Briukhanova, T., Chumak, O., & Yatsenko, O. (2021). Analysis of literature data on the relationship between vitamin D deficiency and type 1 diabetes mellitus. ScienceRise: Biological Science, (2(27), 28–32. https://doi.org/10.15587/2519-8025.2021.235426

Issue

No. 2(27) (2021)

Section

Biological research

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Copyright (c) 2021 Victoriia Fylymonenko, Liubov Galuzinska, Tetiana Briukhanova, Olena Chumak, Olena Yatsenko

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