Development of technology of the soft medicinal form based on the extract of common hazel leaves

Authors

DOI:

https://doi.org/10.15587/2519-4852.2017.100015

Keywords:

Hazel extract, composition, technology, emulsion, ointment, emulsification, dispersion degree, stability, physical and chemical methods

Abstract

Vascular diseases occupy an important place in the morbidity structure of the  population of Azerbaijan. Varicose veins is the most spread pathology among them; it affects between 25% and 50% of the adult population of the country.

The aim of the study was development of technology of the ointment containing Hazel thick extract.

Methods. Physical and chemical methods were used for dispersion, density, emulsification rate, spreadability, and emulsion concentration determination.

Results. The emulsifier concentration of 10% was selected in result of physical and chemical analysis. The oil phase dispersion degree depending on the № 1 emulsifier amount was shown using microscopy method. Thermal and colloidal stability of the ointment samples, as well as their spreadability was determined. It was found that the samples 3 and 4 are characterized by satisfactory spreadability indexes – 350 mm2, that is significantly differs from the samples № 1 (1005 mm2)  and № 2 (852 mm2). Decrease in the emulsifier  concentration below 10% leads to the emulsion instability. On the basis of the research results, rational emulsification conditions were selected. According to the microscopy analysis data and calculation of the emulsion concentration mixing time interval at 1500 rpm was investigated.

 Conclusion. The given research allowed developing of the composition and technology of the ointment containing common Hazel extract

Author Biographies

Jamilya Yusif Yusifova, Azerbaijan Medical University Bakikhanova str., 23, Baku, Azerbaijan, АZ1022

PhD, Associate Professor

Department of pharmaceutical chemistry

Olena Ruban, National University of Pharmacy Pushkinska str., 53, Kharkiv, Ukraine, 61002

Doctor of Pharmaceutical Sciences, Professor, Head of Department

Department of Industrial Technology of Drugs

References

  1. Van den Bos, R., Arends, L., Kockaert, M., Neumann, M., Nijsten, T. (2009). Endovenous therapies of lower extremity varicosities: A meta-analysis. Journal of Vascular Surgery, 49 (1), 230–239. doi: 10.1016/j.jvs.2008.06.030
  2. Naumenko, E. V., Khadartsev, A. A. (Eds.) (2013). Prevention and detection of varicose veins of lower limbs in athletes. Tula: OOO "Tula Polygraphist", 158.
  3. Okley, D. V. (2015). Systemic phlebotropic drugs in pharmacotherapy of chronic venous insufficiency of the lower extremities. News of Pharmacy, 4, 74–77.
  4. Gohel, M., Davies, A. (2009). Pharmacological Agents in the Treatment of Venous Disease: An Update of the Available Evidence. Current Vascular Pharmacology, 7 (3), 303–308. doi: 10.2174/157016109788340758
  5. Varchenko, V., Margitich, V. (2002). The review of the pharmaceutical market of the CIS countries. Pharmacy, 13 (334). Available at: http://www.apteka.ua/article/33198
  6. Movsumov, I. S., Yusifova, D. Yu., Garayev, E. A. (2013). Biologically active substances Corylus avellana L., growing in Azerbaijan. Chemistry of plant raw materials, 4, 259–261. doi: 10.14258/jcprm.1304259
  7. Yusifova, D. Yu., Movsumov, I. S., Maloshtan, L. N., Shatalova, O. M. (2015). Antiinflammatory activity and vasoconstrictive properties of the purified extract from the leaves of the common hazelnut growing in Azerbaijan. Azerbaijan Medical Journal, 3, 93–97.
  8. Emulsions: obtaining, properties, destruction (2012). Samara, 18.
  9. Karyachenko, A. A., Manzhos, Yu. V., Galiakberova, F. N. (2012). Effect of emulsifier content on the average emulsion particle size and emulsification time. Naukovi praci DonNTU. Seriya: «Girny`cho-geologichna», 2 (17), 65–70.
  10. Markov, V. V., Kiseleva, E. V. (2009). Influence of the method of mixing technological fluids on their structure. Bulletin of ISEU, 3, 38–40.

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Published

2017-04-29

How to Cite

Yusifova, J. Y., & Ruban, O. (2017). Development of technology of the soft medicinal form based on the extract of common hazel leaves. ScienceRise: Pharmaceutical Science, (2 (6), 32–37. https://doi.org/10.15587/2519-4852.2017.100015

Issue

No. 2 (6) (2017)

Section

Pharmaceutical Science

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Copyright (c) 2017 Jamilya Yusif Yusifova, Olena Ruban

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