Problem of antibioticorezistence in applicable aspects of ecopharmacy

Authors

DOI:

https://doi.org/10.15587/2519-4852.2021.225220

Keywords:

antibiotic resistance, method of expert survey, ecopharmacy

Abstract

The aim. The aim of the work was to analyze the pharmaceutical fragments as components of the global problem of antibiotic resistance, to evaluate this aspect from the point of view of applied ecopharmacy and to propose solutions to this issue.

Materials and methods. Research materials – the results of a survey of pharmacy specialists. Analytical-comparative, system, logical, mathematical-statistical methods and the method of expert survey of specialists were used. At the first stage of the study, an expert survey of practical pharmacy workers was conducted in order to identify fixed points of correlation between such components as «practical pharmacy» – «antibiotic resistance» – «ecopharmacy». The second stage included the identification of positions at which it is necessary to develop additional informational training activities aimed at reducing antibiotic resistance.

Results. According to the results of an expert survey of specialists of the pharmaceutical sector of Ukraine (Kharkiv, Poltava, Vinnytsia, Chernihiv regions) on key issues of antibiotic resistance from the position of ecopharmacy, it was established that over 90 % of antibacterial drugs are sold without a prescription and are not accompanied by adequate pharmaceutical care. The awareness of pharmacy specialists of the potential dangers from uncontrolled intake of antibacterial drugs rises with an increase in their level of professional competence. Not one of the respondents during the release of an antibacterial drug does not indicate how to dispose of the remaining doses of the drug, what danger does the improper utilization of unsuitable antibiotics to the ecosystem of the region.

Conclusions. According to the results of the research conducted among practical pharmacy experts, conclusions can be drawn about the low level of awareness of the impact of antibacterial drugs on the ecology of the environment; identified key positions for which additional information is needed (antibiotic resistance, ecopharmacy, pharmaceutical care), not only in the form of planned advanced training courses, but also additionally in the format of distance education, seminars, conferences

Author Biographies

Alla Kotvitska, National University of Pharmacy

Doctor of Pharmaceutical Sciences, Professor, Rector

Natalia Tsubanova, National University of Pharmacy

Doctor of Pharmaceutical Sciences, Professor

Department of Clinical Pharmacology

Institute for Advanced Training of Pharmacy Specialists

Nadiia Kononenko, National University of Pharmacy

MD, Professor, Head of Department

Department of Physiology and Pathological Physiology

Victoria Zurenko, National University of Pharmacy

Postgraduate student

Department of Management, Economics and Quality Assurance in Pharmacy

Inna Andrusovich, Kharkiv Medical Academy of Postgraduate Education

Postgraduate student

Department of Infectious Diseases

Valentyna Chikitkina, National University of Pharmacy

PhD, Associate Professor

Department of Physiology and Pathological Physiology

References

  1. Berendonk, T. U., Manaia, C. M., Merlin, C., Fatta-Kassinos, D., Cytryn, E., Walsh, F. et. al. (2015). Tackling antibiotic resistance: the environmental framework. Nature Reviews Microbiology, 13 (5), 310–317. doi: http://doi.org/10.1038/nrmicro3439
  2. WHO, Global antimicrobial resistance surveillance system (GLASS) report: Early implementation 2016–2017 (2018). Geneva: WHO, 164. Available at: www.who.int/glass/resources/publications/early-implementation-report/en/
  3. Pärnänen, K. M. M., Narciso-da-Rocha, C., Kneis, D., Berendonk, T. U., Cacace, D., Do, T. T. et. al. (2019). Antibiotic resistance in European wastewater treatment plants mirrors the pattern of clinical antibiotic resistance prevalence. Science Advances, 5 (3), eaau9124. doi: http://doi.org/10.1126/sciadv.aau9124
  4. Berendonk, T. U., Manaia, C. M., Merlin, C., Fatta-Kassinos, D., Cytryn, E., Walsh, F. et. al. (2015). Tackling antibiotic resistance: the environmental framework. Nature Reviews Microbiology, 13 (5), 310–317. doi: http://doi.org/10.1038/nrmicro3439
  5. FIP statement of policy: Environmentally sustainable pharmacy practice: Green pharmacy (2016). Buenos Aires, 3. Available at: https://www.fip.org/file/1535
  6. Barnett-Itzhaki, Z., Berman, T., Grotto, I., Schwartzberg, E. (2016). Household medical waste disposal policy in Israel. Israel Journal of Health Policy Research, 5 (1). doi: http://doi.org/10.1186/s13584-016-0108-1
  7. Bashaar, M., Thawani, V., Hassali, M. A., Saleem, F. (2017). Disposal practices of unused and expired pharmaceuticals among general public in Kabul. BMC Public Health, 17 (1). doi: http://doi.org/10.1186/s12889-016-3975-z
  8. Manaia, C. M., Rocha, J., Scaccia, N., Marano, R., Radu, E., Biancullo, F. et. al. (2018). Antibiotic resistance in wastewater treatment plants: Tackling the black box. Environment International, 115, 312–324. doi: http://doi.org/10.1016/j.envint.2018.03.044
  9. Sundberg, L.-R., Karvonen, A. (2018). Minor environmental concentrations of antibiotics can modify bacterial virulence in co-infection with a non-targeted parasite. Biology Letters, 14 (12), 20180663. doi: http://doi.org/10.1098/rsbl.2018.0663
  10. Kotvitska, A. A., Tsubanova, N. A., Kononenko, N. M., Ostapets, M. O. (2019). Formation and development perspectives of eco-pharmacy. Journal of Education, Health and Sport, 9 (2), 521–531. doi: http://dx.doi.org/10.5281/zenodo.2613883
  11. Antibiotic Armageddon in UK and Europe by 2025 (2015). European Society of Clinical Microbiology and Infectious Diseases. 2015 Available at: https://www.biospace.com/article/releases/-b-escmid-b-release-antibiotic-armageddon-in-uk-and-europe-by-2025-/
  12. Barriere, S. L. (2014). Clinical, economic and societal impact of antibiotic resistance. Expert Opinion on Pharmacotherapy, 16 (2), 151–153. doi: http://doi.org/10.1517/14656566.2015.983077
  13. O’Neill, J. (2014). The Review on Antimicrobial Resistance: tackling a crisis for the health and wealth of nations. Available at: https://wellcomecollection.org/works/rdpck35v
  14. AnalystSoft Inc., StatPlus is a statistical analysis program. Version 6. Available at: www.analystsoft.com/ru/
  15. Felis, E., Kalka, J., Sochacki, A., Kowalska, K., Bajkacz, S., Harnisz, M., Korzeniewska, E. (2020). Antimicrobial pharmaceuticals in the aquatic environment – occurrence and environmental implications. European Journal of Pharmacology, 866, 172813. doi: http://doi.org/10.1016/j.ejphar.2019.172813
  16. Polanco Allué, I. (2015). Microbiota and gastrointestinal diseases. Anales de Pediatría (English Edition), 83 (6), 443.e1–443.e5. doi: http://doi.org/10.1016/j.anpede.2015.11.003

Downloads

Published

2021-02-27

How to Cite

Kotvitska, A., Tsubanova, N., Kononenko, N., Zurenko, V., Andrusovich, I., & Chikitkina, V. (2021). Problem of antibioticorezistence in applicable aspects of ecopharmacy. ScienceRise: Pharmaceutical Science, (1 (29), 4–9. https://doi.org/10.15587/2519-4852.2021.225220

Issue

Section

Pharmaceutical Science