Screening study of the antihyperglycemic action of new solid quercetin dispersions

Authors

DOI:

https://doi.org/10.15587/2519-4852.2021.247443

Keywords:

quercetin, solid dispersion, hydroxypropyl methylcellulose, polyvinylpyrrolidone, diabetes mellitus, screening, antihyperglycemic action

Abstract

The aim – to screen new solid dispersions of quercetin for the presence of antihyperglycemic action and to identify the most active substances that are promising for the creation of antidiabetic drugs.

Materials and methods. The object of the study was 4 new solid dispersions of quercetin, developed at the National University of Pharmacy. Solid dispersions of quercetin were prepared by the liquid-phase method; hydroxypropyl methylcellulose (HPMC) or polyvinylpyrrolidone (PVP) in ratios of 1:1 and 1:2 were used as a carrier. The antihyperglycemic effect of the studied substances at a dose of 50 mg / kg was assessed in rats by the ability to lower blood glucose levels after carbohydrate loading in a model of impaired glucose tolerance induced by dexamethasone and in experimental type 2 diabetes mellitus induced by dexamethasone.

Results. It was found that with impaired glucose tolerance, a solid dispersion of quercetin with HPMC (1:1) showed a pronounced antihyperglycemic effect – the glucose level 30 minutes after glucose load significantly decreased by 28 % and did not differ from the action of metformin, which was confirmed by the value of the area under glycemic crooked. When solid dispersions with PVP (1:1 and 1:2) were used, the antihyperglycemic effect was less pronounced. In a model of type 2 diabetes mellitus, a significant antihyperglycemic effect was found only in a solid dispersion of quercetin with HPMC (1:1) at the metformin level, which indicates an increase in the solubility and absorption of quercetin.

Conclusions. A pronounced antihyperglycemic effect at the metformin level was found in a solid dispersion of quercetin with HPMC in a 1:1 ratio with impaired glucose tolerance and type 2 diabetes mellitus. It has been proven that a solid dispersion of quercetin with HPMC is a promising substance for creating a monocomponent drug or for inclusion in a new antidiabetic combined drug

Author Biographies

Olena Ruban, National University of Pharmacy

Doctor of Pharmaceutical Sciences, Professor, Head of Department

Department of Industrial Technology of Drugs

Nadiia Kononenko, National University of Pharmacy

Doctor of Medical Sciences, Professor, Head of Department

Department of Physiology and Pathological Physiology

Inna Kovalevska, National University of Pharmacy

Doctor of Pharmaceutical Sciences, Associate Professor

Department of Industrial Technology of Drugs

Valentyna Chikitkina, National University of Pharmacy

PhD, Associate Professor

Department of Physiology and Pathological Physiology

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Published

2021-12-08

How to Cite

Ruban, O., Kononenko, N., Kovalevska, I., & Chikitkina, V. (2021). Screening study of the antihyperglycemic action of new solid quercetin dispersions. ScienceRise: Pharmaceutical Science, (6 (34), 37–42. https://doi.org/10.15587/2519-4852.2021.247443

Issue

No. 6 (34) (2021)

Section

Pharmaceutical Science

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Copyright (c) 2021 Olena Ruban, Nadiia Kononenko, Inna Kovalevska, Valentyna Chikitkina

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