Interaction of surfactants with poloxamers 338 and its effect on some properties of cream base

Authors

DOI:

https://doi.org/10.15587/2519-4852.2021.249312

Keywords:

poloxamer 338 (P338), surfactant, micelle, cream base, spin probe, rotational correlation time (τ), rheological parameters

Abstract

The aim. Study of the interaction of surfactants with poloxamer 338 (P338) and the effect of P338 on the properties of cream bases.

Materials and methods. Solutions of the surfactants and P338 as well as cream bases were under study. The average hydrodynamic diameter (Dh) and zeta potential (ζ‑potential) were determined by the light scattering intensity and electrophoretic mobility of micelles. The electron paramagnetic resonance (EPR) spectra of spin probes in micelles, solvents and bases were obtained; the type of spectrum, isotropic constant (AN), rotational correlation times (τ) and anisotropy parameter (ε) were determined. Liquids and cream bases were studied by capillary and rotational viscometry; the flow behaviour and yield stress (t0), dynamic and apparent viscosity (η) as well as the hysteresis (thixotropic) area (AH) were determined. The microstructure of the bases was examined by optical microscopy. The strength of adhesion (Sm) was assessed by the pull-off test, and the absorption of water was studied by dialysis.

Results. Under the impact of P338 the hydrodynamic diameters of micelles formed by cationic, anionic and nonionic surfactants decreased as well as the absolute values of their ζ‑potential became lower, but the microviscosity of the micelle nuclei increased. There was also a change in the structure of the aggregates of surfactant with fatty alcohols; EPR spectra, which were superpositions characteristic for the lateral phase separation, converted into triplets that indicated the uniform distribution of lipophilic probes in the surfactant phase. When the content of P338 increased to 17 %, the rheological parameters of the bases increased drastically, the flow behaviour and the microstructure changed. The bases had the consistency of cream within temperature range from 25 °C to 70 °C and completely restored their apparent viscosity, which had decreased under shear stress. P338 enhances the adhesive properties of the bases. Due to their microstructure, cream bases have a lower ability to absorb water compared to a solution and gel containing 17 % and 20 % P338, respectively.

Conclusions. The structure of surfactant micelles and aggregates of surfactants with fatty alcohols changed under impact of P338 due to the interaction of surfactants with P338. As a result of this interaction, at a sufficiently high concentration of P338, the microstructure and flow behaviour of bases changed, their rheological parameters, which remain high at temperatures from 25 °C to 70 °C, increased significantly, and water absorption parameters decreased. The bases with P338 were more adhesive

Author Biographies

Elena Bezuglaya, State Scientific Institution “Institute for Single Crystals” of National Academy of Sciences of Ukraine

PhD, Senior Researcher, Head of Laboratory

Laboratory of Technology and Analysis of Medicinal Products

Nikolay Lyapunov, State Scientific Institution “Institute for Single Crystals” of National Academy of Sciences of Ukraine

Doctor of Pharmaceutical Sciences, Professor, Leading Researcher

Laboratory of Technology and Analysis of Medicinal Products

Oleksii Lysokobylka, State Scientific Institution “Institute for Single Crystals” of National Academy of Sciences of Ukraine

Junior Researcher

Laboratory of Technology and Analysis of Medicinal Products

Oleksii Liapunov, State Scientific Institution “Institute for Single Crystals” of National Academy of Sciences of Ukraine

PhD, Researcher

Laboratory of Technology and Analysis of Medicinal Products

Volodimir Klochkov, State Scientific Institution “Institute for Scintillation Materials” of National Academy of Sciences of Ukraine

PhD, Senior Researcher

Department of Nanostructured Materials

Hanna Grygorova, State Scientific Institution “Institute for Scintillation Materials” of National Academy of Sciences of Ukraine

PhD, Senior Researcher

Department of Nanostructured Materials

Anna Liapunova, State Scientific Institution “Institute for Single Crystals” of National Academy of Sciences of Ukraine

PhD, Researcher

Laboratory of Technology and Analysis of Medicinal Products

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Published

2021-12-30

How to Cite

Bezuglaya, E., Lyapunov, N., Lysokobylka, O., Liapunov, O., Klochkov, V., Grygorova, H., & Liapunova, A. (2021). Interaction of surfactants with poloxamers 338 and its effect on some properties of cream base. ScienceRise: Pharmaceutical Science, (6 (34), 4–19. https://doi.org/10.15587/2519-4852.2021.249312

Issue

No. 6 (34) (2021)

Section

Pharmaceutical Science

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Copyright (c) 2021 Елена Петровна Безуглая, Николай Александрович Ляпунов, Алексей Андреевич Лысокобылка, Алексей Николаевич Ляпунов, Владимир Кириллович Клочков, Анна Владимировна Григорова, Анна Николаевна Ляпунова

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